Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse

Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies

2000 • 1,334 citations

Biologic and pharmacologic regulation of mammalian glutathione synthesis

1999 • 1,178 citations

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1989 • 987 citations

Cloning and Expression of a Plasma Membrane Cystine/Glutamate Exchange Transporter Composed of Two Distinct Proteins

1999 • 982 citations

The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants

1998 • 936 citations

The Circuitry Mediating Cocaine-Induced Reinstatement of Drug-Seeking Behavior

2001 • 905 citations

Neurobiology of Relapse to Heroin and Cocaine Seeking: A Review

2002 • 874 citations

Prefrontal Glutamate Release into the Core of the Nucleus Accumbens Mediates Cocaine-Induced Reinstatement of Drug-Seeking Behavior

2003 • 869 citations

Metabotropic glutamate receptors: electrophysiological properties and role in plasticity

1999 • 770 citations

Synaptic interactions among excitatory afferents to nucleus accumbens neurons: hippocampal gating of prefrontal cortical input

1995 • 754 citations

Psychomotor stimulant addiction: a neural systems perspective.

2002 • 635 citations

Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine

2001 • 622 citations

Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization

1996 • 609 citations

Psychomotor Stimulant Addiction: A Neural Systems Perspective

2002 • 573 citations

The Origin and Neuronal Function ofIn VivoNonsynaptic Glutamate

2002 • 571 citations

Glutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction

2000 • 545 citations

Electrophile Response Element-mediated Induction of the Cystine/Glutamate Exchange Transporter Gene Expression

2002 • 498 citations

Brain microdialysis of GABA and glutamate: What does it signify?

1997 • 393 citations

Rapid and Accurate HPLC Assay for Plasma Total Homocysteine and Cysteine in a Clinical Laboratory Setting

1999 • 377 citations

Compromised Glutamate Transport in Human Glioma Cells: Reduction–Mislocalization of Sodium-Dependent Glutamate Transporters and Enhanced Activity of Cystine–Glutamate Exchange

1999 • 339 citations

Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour

2003 • 317 citations

Cocaine Administered into the Medial Prefrontal Cortex Reinstates Cocaine-Seeking Behavior by Increasing AMPA Receptor-Mediated Glutamate Transmission in the Nucleus Accumbens

2002 • 303 citations

Repeated administration of cocaine or amphetamine alters neuronal responses to glutamate in the mesoaccumbens dopamine system.

1995 • 291 citations

Dissociable Effects of Antagonism of NMDA and AMPA/KA Receptors in the Nucleus Accumbens Core and Shell on Cocaine-seeking Behavior

2001 • 287 citations

A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior

1999 • 250 citations

Cocaine and amphetamine preferentially stimulate glutamate release in the limbic system: Studies on the involvement of dopamine

1997 • 203 citations

Distribution of Cystine/Glutamate Exchange Transporter, System x_c⁻, in the Mouse Brain

2002 • 166 citations

Alterations in behaviour and glutamate transmission following presentation of stimuli previously associated with cocaine exposure

2001 • 160 citations

Modulation of extracellular glutamate concentration in rat brain slices by cystine‐glutamate exchange

1999 • 137 citations

Cocaine increases extraneuronal levels of aspartate and glutamate in the nucleus accumbens

1995 • 135 citations

[74] Methods for the selective modification of glutathione metabolism and study of glutathione transport

1985 • 131 citations

Promoting glutathione synthesis after spinal cord trauma decreases secondary damage and promotes retention of function

2001 • 110 citations

Metabotropic Glutamate Receptors in the Rat Nucleus Accumbens

1997 • 101 citations

Dibutyryl‐cAMP (dbcAMP) up‐regulates astrocytic chloride‐dependent <scp>l</scp>‐[³H]glutamate transport and expression of both system x_c⁻ subunits

2001 • 71 citations

A role for γ-glutamyl transpeptidase in the transport of cystine into human endothelial cells: relationship to intracellular glutathione

1994 • 64 citations

Characterization of multiple cysteine and cystine transporters in rat alveolar type II cells

1997 • 55 citations

xCT Cystine Transporter Expression in HEK293 Cells: Pharmacology and Localization

2001 • 49 citations

Induction of cystine transport via system xc− and maintenance of intracellular glutathione levels in pancreatic acinar and islet cell lines

1998 • 42 citations

Reduced glutamate immunolabeling in the nucleus accumbens following extended withdrawal from self-administered cocaine

1998 • 42 citations

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