Double-Blind, Placebo-Controlled Study on the Effect of the Aldosterone Receptor Antagonist Spironolactone in Patients Who Have Persistent Proteinuria and Are on Long-Term Angiotensin-Converting Enzyme Inhibitor Therapy, with or without an Angiotensin II Receptor Blocker

Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy

1997 • 1,775 citations

Effect of the Angiotensin-Converting–Enzyme Inhibitor Benazepril on the Progression of Chronic Renal Insufficiency

1996 • 1,759 citations

RETRACTED: Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial

2003 • 974 citations

Role of aldosterone in the remnant kidney model in the rat.

1996 • 473 citations

Effectiveness of Aldosterone Blockade in Patients With Diabetic Nephropathy

2003 • 458 citations

Proteinuria reduction and progression to renal failure in patients with type 2 diabetes mellitus and overt nephropathy

2005 • 369 citations

Combination therapy with ACE inhibitors and angiotensin II receptor blockers to halt progression of chronic renal disease: Pathophysiology and indications

2005 • 289 citations

Beneficial Effects of Adding Spironolactone to Recommended Antihypertensive Treatment in Diabetic Nephropathy

2005 • 288 citations

Dual blockade of the renin-angiotensin system versus maximal recommended dose of ACE inhibition in diabetic nephropathy

2003 • 234 citations

Management of Glomerular Proteinuria

2003 • 210 citations

?Escape? of aldosterone production in patients with left ventricular dysfunction treated with an angiotensin converting enzyme inhibitor: Implications for therapy

1995 • 206 citations

The blunting of the antiproteinuric efficacy of ACE inhibition by high sodium intake can be restored by hydrochlorothiazide

1998 • 199 citations

Dual renin-angiotensin system blockade at optimal doses for proteinuria

2002 • 169 citations

The effect of spironolactone, cilazapril and their combination on albuminuria in patients with hypertension and diabetic nephropathy is independent of blood pressure reduction: a randomized controlled study

2004 • 145 citations

Antagonists of Aldosterone and Proteinuria in Patients With CKD: An Uncontrolled Pilot Study

2005 • 141 citations

Dual blockade of the renin-angiotensin system in type 1 patients with diabetic nephropathy

2002 • 129 citations

Antiproteinuric effects of mineralocorticoid receptor blockade in patients with chronic renal disease

2005 • 129 citations

Interaction of spironolactone with ACE inhibitors or angiotensin receptor blockers: analysis of 44 cases

2003 • 119 citations

Diuretic and Enhanced Sodium Restriction Results in Improved Antiproteinuric Response to RAS Blocking Agents

2004 • 117 citations

Randomized controlled crossover study of the effect on proteinuria and blood pressure of adding an angiotensin II receptor antagonist to an angiotensin converting enzyme inhibitor in normotensive patients with chronic renal disease and proteinuria

2002 • 87 citations

Adrenalectomy ameliorates ablative nephropathy in the rat independently of corticosterone maintenance level

1992 • 69 citations

Eplerenone reduces proteinuria in type II diabetes mellitus: implications for aldosterone involvement in the pathogenesis of renal dysfunction

2002 • 36 citations

Dual blockade of the renin-angiotensin system compared with a 50% increase in the dose of angiotensin-converting enzyme inhibitor: effects on proteinuria and blood pressure

2004 • 21 citations

Relation of myocardial fibrosis to circulating aldosterone and endothelin in primary and secondary human hypertension: an ultrasonic study by acoustic densitometry

2002 • 2 citations

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