Beneficial Effects of Adding Spironolactone to Recommended Antihypertensive Treatment in Diabetic Nephropathy

Mixed-Effects Models in S and S-PLUS

2001 • 9,637 citations

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2000 • 9,621 citations

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1999 • 8,588 citations

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2001 • 7,165 citations

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1998 • 6,576 citations

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2001 • 5,812 citations

The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

1993 • 5,296 citations

Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38

1998 • 4,813 citations

Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction

2003 • 4,640 citations

The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

2000 • 2,991 citations

The Effect of Irbesartan on the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes

2001 • 2,520 citations

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2000 • 1,050 citations

Multiple actions of steroid hormones--a focus on rapid, nongenomic effects.

2000 • 980 citations

Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: Lessons from RENAAL

2004 • 956 citations

A Simple Method for the Determination of Glomerular Filtration Rate

1972 • 870 citations

Albuminuria, a Therapeutic Target for Cardiovascular Protection in Type 2 Diabetic Patients With Nephropathy

2004 • 729 citations

Reduction in Albuminuria Translates to Reduction in Cardiovascular Events in Hypertensive Patients

2005 • 565 citations

The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: The RENAAL Study

2003 • 527 citations

Mineralocorticoid Blockade Reduces Vascular Injury in Stroke-Prone Hypertensive Rats

1998 • 504 citations

Effectiveness of Spironolactone Added to an Angiotensin-Converting Enzyme Inhibitor and a Loop Diuretic for Severe Chronic Congestive Heart Failure (The Randomized Aldactone Evaluation Study [RALES])**See Appendix for full list of RALES investigators.

1996 • 472 citations

Aldosterone: A Mediator of Myocardial Necrosis and Renal Arteriopathy*

2000 • 459 citations

Effectiveness of Aldosterone Blockade in Patients With Diabetic Nephropathy

2003 • 458 citations

Progression of nephropathy in type 2 diabetic patients

2004 • 342 citations

Aldosterone escape during blockade of the renin?angiotensin?aldosterone system in diabetic nephropathy is associated with enhanced decline in glomerular filtration rate

2004 • 230 citations

Renoprotective Effects of Adding Angiotensin II Receptor Blocker to Maximal Recommended Doses of ACE Inhibitor in Diabetic Nephropathy

2003 • 222 citations

Dual Blockade of the Renin-Angiotensin System in Diabetic Nephropathy

2002 • 209 citations

Reduction in albuminuria predicts a beneficial effect on diminishing the progression of human diabetic nephropathy during antihypertensive treatment

1994 • 195 citations

Nongenomic Vascular Action of Aldosterone in the Glomerular Microcirculation

2003 • 189 citations

Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats

2004 • 179 citations

Aldosterone as a mediator of progressive renal disease: Pathogenetic and clinical implications

2001 • 156 citations

The effect of spironolactone, cilazapril and their combination on albuminuria in patients with hypertension and diabetic nephropathy is independent of blood pressure reduction: a randomized controlled study

2004 • 145 citations

Failure of aldosterone suppression despite angiotensin-converting enzyme (ACE) inhibitor administration in chronic heart failure is associated with ACE DD genotype

2001 • 140 citations

Dual blockade of the renin-angiotensin system in type 1 patients with diabetic nephropathy

2002 • 129 citations

Asynchronous changes in prorenin and renin secretion after captopril in patients with renal artery stenosis.

1983 • 129 citations

Antiproteinuric effects of mineralocorticoid receptor blockade in patients with chronic renal disease

2005 • 129 citations

Spironolactone impairs endothelial function and heart rate variability in patients with Type 2 diabetes

2004 • 117 citations

Improved survival in patients obtaining remission of nephrotic range albuminuria in diabetic nephropathy

2004 • 93 citations

Aldosterone as a Determinant of Cardiovascular and Renal Dysfunction

2001 • 72 citations

Aldosterone in progressive renal disease

2001 • 39 citations

Eplerenone reduces proteinuria in type II diabetes mellitus: implications for aldosterone involvement in the pathogenesis of renal dysfunction

2002 • 36 citations

Dual Blockade of the Renin-angiotensin-aldosterone System in Diabetic Nephropathy: The Role of Aldosterone

2005 • 32 citations