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Molecular Chaperones in the Yeast Endoplasmic Reticulum Maintain the Solubility of Proteins for Retrotranslocation and Degradation

Data up to Jan 2025

Published2001
Citations328
References74

Total Citations Per Year

Abstract

References (74)

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

Methods in yeast genetics

1979 • 7,824 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

2000 • 1,939 citations

Methods in Yeast Genetics: A Laboratory Course Manual

1990 • 1,922 citations

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

1996 • 1,680 citations

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

Laboratory course manual for methods in yeast genetics

1986 • 1,310 citations

70K heat shock related proteins stimulate protein translocation into microsomes

1988 • 1,276 citations

Setting the Standards: Quality Control in the Secretory Pathway

1999 • 1,198 citations

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1996 • 1,101 citations

Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.

1988 • 977 citations

Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK.

1991 • 835 citations

ER Degradation of a Misfolded Luminal Protein by the Cytosolic Ubiquitin-Proteasome Pathway

1996 • 704 citations

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

1997 • 556 citations

Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate

1996 • 451 citations

BiP Acts as a Molecular Ratchet during Posttranslational Transport of Prepro-α Factor across the ER Membrane

1999 • 435 citations

[31] Tackling the protease problem in Saccharomyces cerevisiae

1991 • 427 citations

BiP Maintains the Permeability Barrier of the ER Membrane by Sealing the Lumenal End of the Translocon Pore before and Early in Translocation

1998 • 427 citations

A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum.

1987 • 418 citations

Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation

1997 • 412 citations

Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.

1996 • 400 citations

The J-domain family and the recruitment of chaperone power

1998 • 396 citations

Selective Inhibitors of the Proteasome-dependent and Vacuolar Pathways of Protein Degradation in Saccharomyces cerevisiae

1996 • 395 citations

70-kD heat shock-related protein is one of at least two distinct cytosolic factors stimulating protein import into mitochondria.

1988 • 380 citations

The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene

1993 • 379 citations

Yeast Saccharomyces cerevisiae selectable markers in pUC18 polylinkers

1990 • 376 citations

Retrograde protein translocation: ERADication of secretory proteins in health and disease

1999 • 371 citations

Sec61p and BiP directly facilitate polypeptide translocation into the ER

1992 • 370 citations

Degradation of a Mutant Secretory Protein, α1-Antitrypsin Z, in the Endoplasmic Reticulum Requires Proteasome Activity

1996 • 362 citations

Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum.

1992 • 352 citations

ER protein quality control and proteasome-mediated protein degradation

1999 • 348 citations

Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation

1996 • 346 citations

Protein Sorting in Saccharomyces cerevisiae: Isolation of Mutants Defective in the Delivery and Processing of Multiple Vacuolar Hydrolases

1988 • 339 citations

Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast.

1989 • 339 citations

A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein.

1989 • 296 citations

A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome.

1993 • 290 citations

The Requirement for Molecular Chaperones during Endoplasmic Reticulum-associated Protein Degradation Demonstrates That Protein Export and Import Are Mechanistically Distinct

1999 • 286 citations

Hsp70 Molecular Chaperone Facilitates Endoplasmic Reticulum-associated Protein Degradation of Cystic Fibrosis Transmembrane Conductance Regulator in Yeast

2001 • 275 citations

Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway.

1996 • 273 citations

Functional Interaction of Cytosolic hsp70 and a DnaJ-Related Protein, Ydj1p, in Protein Translocation In Vivo

1996 • 235 citations

Gene dosage-dependent secretion of yeast vacuolar carboxypeptidase Y.

1986 • 217 citations

Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein

1998 • 206 citations

Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast

1993 • 205 citations

BiP/Kar2p serves as a molecular chaperone during carboxypeptidase Y folding in yeast.

1995 • 192 citations

Endoplasmic Reticulum Degradation of a Mutated ATP-binding Cassette Transporter Pdr5 Proceeds in a Concerted Action of Sec61 and the Proteasome

1998 • 188 citations

Degradation of Proteins from the ER of S. cerevisiae Requires an Intact Unfolded Protein Response Pathway

2000 • 185 citations

A novel Hsp70 of the yeast ER lumen is required for the efficient translocation of a number of protein precursors.

1996 • 176 citations

Determination of the Transmembrane Topology of Yeast Sec61p, an Essential Component of the Endoplasmic Reticulum Translocation Complex

1996 • 152 citations

The Lumenal Domain of Sec63p Stimulates the ATPase Activity of BiP and Mediates BiP Recruitment to the Translocon in Saccharomyces cerevisiae

1997 • 151 citations

A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s.

1995 • 151 citations

Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane

1999 • 147 citations

Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of DnaK and DnaJ in the endoplasmic reticulum.

1993 • 135 citations

The Engagement of Sec61p in the ER Dislocation Process

1999 • 127 citations

Intracellular Disposal of Incompletely Folded Human α1-Antitrypsin Involves Release from Calnexin and Post-translational Trimming of Asparagine-linked Oligosaccharides

1997 • 124 citations

Ste6p Mutants Defective in Exit from the Endoplasmic Reticulum (ER) Reveal Aspects of an ER Quality Control Pathway inSaccharomyces cerevisiae

1998 • 113 citations

Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae.

1995 • 113 citations

Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system

2000 • 103 citations

The Yeast JEM1p Is a DnaJ-like Protein of the Endoplasmic Reticulum Membrane Required for Nuclear Fusion

1997 • 91 citations

A Role for the DnaJ Homologue Scj1p in Protein Folding in the Yeast Endoplasmic Reticulum

1998 • 91 citations

Chapter 1 A Hitchhiker's Guide to Analysis of the Secretory Pathway in Yeast

1989 • 88 citations

Inhibition of endoplasmic reticulum (ER)-to-Golgi transport induces relocalization of binding protein (BiP) within the ER to form the BiP bodies.

1994 • 88 citations

SSI1 Encodes a Novel Hsp70 of the Saccharomyces cerevisiae Endoplasmic Reticulum

1996 • 78 citations

SSS1 encodes a stabilizing component of the Sec61 subcomplex of the yeast protein translocation apparatus.

1994 • 76 citations

Sec61p Serves Multiple Roles in Secretory Precursor Binding and Translocation into the Endoplasmic Reticulum Membrane

1998 • 75 citations

The Hsp70 Homologue Lhs1p Is Involved in a Novel Function of the Yeast Endoplasmic Reticulum, Refolding and Stabilization of Heat-denatured Protein Aggregates

1997 • 73 citations

The GTP-binding Sar1 protein is localized to the early compartment of the yeast secretory pathway

1991 • 64 citations

Re‐entering the translocon from the lumenal side of the endoplasmic reticulum. Studies on mutated carboxypeptidase yscY species

1999 • 56 citations

Cer1p, a Novel Hsp70-related Protein Required for Posttranslational Endoplasmic Reticulum Translocation in Yeast

1996 • 54 citations

Distinct Domains within Yeast Sec61p Involved in Post-translational Translocation and Protein Dislocation

2000 • 48 citations

Binding of Mitochondrial Presequences to Yeast Cytosolic Heat Shock Protein 70 Depends on the Amphiphilicity of the Presequence

1996 • 48 citations

Genetic Interactions betweenKAR7/SEC71,KAR8/JEM1,KAR5, andKAR2during Nuclear Fusion inSaccharomyces cerevisiae

1999 • 44 citations

Calnexin and BiP Interact with Acid Phosphatase Independently of Glucose Trimming and Reglucosylation inSchizosaccharomyces pombe

1998 • 34 citations

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Molecular Chaperones in the Yeast Endoplasmic Reticulum Maintain the Solubility of… (2001) – The Journal of Cell Biology | Metascience Observatory Explorer