Drugs inhibiting HMG-CoA reductase

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

1980 • 1,607 citations

Regulation of Plasma Cholesterol by Lipoprotein Receptors

1981 • 958 citations

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.

1976 • 926 citations

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

1976 • 788 citations

Lipoprotein receptors and cholesterol homeostasis

1983 • 755 citations

Monacolin K, a new hypocholesterolemic agent produced by a Monascus species.

1979 • 667 citations

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

1983 • 562 citations

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1978 • 556 citations

Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit) *1Incidence and development of atherosclerosis and xanthoma

1980 • 540 citations

Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.

1981 • 424 citations

Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and swiss 3T3 cells stimulated to divide by platelet-derived growth factor.

1980 • 353 citations

Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactum

1976 • 351 citations

Essential role for mevalonate synthesis in DNA replication

1979 • 297 citations

Compactin (ML-236B) and related compounds as potential cholesterol-lowering agents that inhibit HMG-CoA reductase

1985 • 285 citations

Effects of an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase on Serum Lipoproteins and Ubiquinone-10 Levels in Patients with Familial Hypercholesterolemia

1981 • 262 citations

Inhibition of Cholesterol Synthesis in vitro and in vivo by ML‐236A and ML‐236B, Competitive Inhibitors of 3‐Hydroxy‐3‐methylglutaryl‐Coenzyme A Reductase

1977 • 261 citations

Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia.

1981 • 254 citations

Inhibitory Effects on Lipid Metabolismn in Cultured Cells of ML‐236B, a Potent Inhibitor of 3‐Hydroxt‐3‐methylglutaryl‐Cornzyme‐A Reductase

1978 • 252 citations

Therapeutic effects of ML-236B in primary hypercholesterolemia

1980 • 231 citations

Effects of ML-236B on cholesterol metabolism in mice and rats: Lack of hypocholesterolemic activity in normal animals

1979 • 218 citations

Cholesterol-lowering effect of mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme a reductase, in healthy volunteers.

1982 • 206 citations

Reduction of Serum Cholesterol in Heterozygous Patients with Familial Hypercholesterolemia

1983 • 201 citations

WHHL‐Rabbit: a low density lipoprotein receptor‐deficient animal model for familial hypercholesterolemia

1980 • 190 citations

Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase

1979 • 110 citations

Monacolins J and L, new inhibitors of cholesterol biosynthesis produced by Monascus ruber.

1985 • 103 citations

Mevalonate supplementation in pregnant rats suppresses the teratogenicity of mevinolinic acid, an inhibitor of 3‐hydroxy‐3‐methylglutaryl‐coenzyme a reductase

1983 • 103 citations

Rapid and substantial lowering of human serum cholesterol by mevinolin (MK-803), an inhibitor of hydroxymethylglutaryl-coenzyme a reductase

1982 • 94 citations

Microbial hydroxylation of ML-236B (compactin) and monacolin K (MB-530B)

1983 • 94 citations

Mechanism for elevation of hepatic cholesterol synthesis and serum cholesterol levels in triton WR-1339-induced hyperlipidemia

1977 • 89 citations

Dihydromonacolin L and monacolin X. new metabolites those inhibit cholesterol biosynthesis.

1985 • 82 citations

Hypolipidemic effects in monkeys of ML‐236B, a competitive inhibitor of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase

1979 • 81 citations

The effect of compactin, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme—A reductase activity, on cholesterogenesis and serum cholesterol levels in rats and chicks

1980 • 67 citations

Dihydromevinolin,a potent hypocholesterolemic metabolite produced by Aspergillus terreus.

1981 • 66 citations

Correlation between two effects of high density lipoproteins on vascular endothelial cells. The induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and the support of cellular proliferation.

1982 • 65 citations

Kinetic Analysis of the Reaction Catalyzed by Rat‐Liver 3‐Hydroxy‐3‐methylglutaryl‐coenzyme‐A Reductase Using Two Specific Inhibitors

1979 • 61 citations

Linkage of the isoprenoid biosynthetic pathway with induction of DNA synthesis in mouse lymphocytes effects of compactin on mitogen-induced lymphocytes in serum-free medium

1982 • 57 citations

Biological and pharmacological activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase

1981 • 56 citations

Isolation and characterization of cells resistant to ML236B (compactin) with increased levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1981 • 53 citations

The effects of mevinolin on serum cholesterol levels of rabbits with endogenous hypercholesterolemia

1982 • 51 citations

Hypolipidemic effects of CS-500 (ML-236B) in WHHL-rabbit, a heritable animal model for hyperlipidemia

1981 • 51 citations

Sterol metabolism and lymphocyte function: inhibition of endogenous sterol biosynthesis does not prevent mitogen-induced human T lymphocyte activation.

1980 • 48 citations

Dihydrocompactin,a new potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme-A reductase from Penicillium citrinum.

1981 • 45 citations

3.ALPHA.-Hydroxy-ML-236B(3.ALPHA.-hydroxycompactin), microbial transformation product of ML-236B (compactin)

1983 • 37 citations

Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vascular endothelial cells. Separate sterol and non-sterol components.

1982 • 36 citations

Microbial phosphorylation of compactin (ML-236B) and related compounds.

1985 • 24 citations

Microbial hydroxylation of compactin (ML-236B) and monacolin K.

1985 • 23 citations

6.ALPHA.-Hydroxy-iso-ML-236B (6.ALPHA.-hydroxy-iso-compactin) and ML-236A, Microbial transformation products of ML-236B.

1983 • 23 citations

Combined drug therapy--cholestyramine and compactin--for familial hypercholesterolemia.

1984 • 17 citations

Two Japanese Kindreds of Familial Hypercholesterolemia Including Homozygous Cases. A Report of Cases, and Studies on Serum-Lipoproteins and Enzymes

1978 • 11 citations

Long-term (5-year) Effects of Plasma Exchange in a Homozygous Patient with Familial Hypercholesterolemia

1986 • 1 citations