Loss of Bim Allows Precursor B Cell Survival But Not Precursor B Cell Differentiation in the Absence of Interleukin 7

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

BAFF and APRIL: A Tutorial on B Cell Survival

2003 • 946 citations

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1

2003 • 771 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

QUANTIFICATION OF MURINE CYTOKINE mRNAs USING REAL TIME QUANTITATIVE REVERSE TRANSCRIPTASE PCR

1999 • 567 citations

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

2002 • 564 citations

Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor

2000 • 405 citations

Identification of the Earliest B Lineage Stage in Mouse Bone Marrow

1996 • 395 citations

Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

1998 • 331 citations

Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells

2003 • 296 citations

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine.

1995 • 227 citations

The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis.

1996 • 213 citations

The Earliest Step in B Lineage Differentiation from Common Lymphoid Progenitors Is Critically Dependent upon Interleukin 7

2002 • 198 citations

Impaired Ability of Bone Marrow Stromal Cells to Support B-Lymphopoiesis With Age

1998 • 193 citations

Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation.

1994 • 189 citations

Complementary Signaling through flt3 and Interleukin-7 Receptor α Is Indispensable for Fetal and Adult B Cell Genesis

2003 • 174 citations

Age-associated thymic atrophy is linked to a decline in IL-7 production

2002 • 174 citations

Pre-B Cell Receptor Signaling Mediates Selective Response to IL-7 at the Pro-B to Pre-B Cell Transition via an ERK/MAP Kinase-Dependent Pathway

2001 • 172 citations

Precursor B Cell Receptor–Dependent B Cell Proliferation and Differentiation Does Not Require the Bone Marrow or Fetal Liver Environment

2000 • 171 citations

The Resolution of Relapsing Fever Borreliosis Requires IgM and Is Concurrent with Expansion of B1b Lymphocytes

2003 • 163 citations

The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors

1995 • 162 citations

Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development

2003 • 153 citations

Absence of an Essential Role for Thymic Stromal Lymphopoietin Receptor in Murine B-Cell Development

2004 • 152 citations

Early B‐Cell Development in the Mouse: Insights from Mutations Introduced by Gene Targeting

1994 • 142 citations

Modulation of the IL-7 Dose-Response Threshold During Pro-B Cell Differentiation Is Dependent on Pre-B Cell Receptor Expression

1998 • 138 citations

Quantitative analysis of lymphocyte differentiation and proliferation in vitro using carboxyfluorescein diacetate succinimidyl ester

1999 • 136 citations

Functional Assessment of Precursors from Murine Bone Marrow Suggests a Sequence of Early B Lineage Differentiation Events

2000 • 130 citations

Frequent Aberrant Immunoglobulin Gene Rearrangements in Pro-B Cells Revealed by a bcl-x Transgene

1996 • 120 citations

Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin‐11 and interleukin‐7

1996 • 115 citations

Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors.

1995 • 90 citations

Unique Signaling Properties of B Cell Antigen Receptor in Mature and Immature B Cells: Implications for Tolerance and Activation

2001 • 84 citations

Murine Pro-B Cells Require IL-7 and Its Receptor Complex to Up-Regulate IL-7Rα, Terminal Deoxynucleotidyltransferase, and cμ Expression

2000 • 69 citations

Cooperation between IL-7 and the pre-B cell receptor: a key to B cell selection

2002 • 64 citations

Development of B Lymphocytes from Lymphoid Committed and Uncommitted Progenitors

1994 • 38 citations

Lymphoproliferative disorders in an IL-7 transgenic mouse line.

1993 • 37 citations

In vitro tracking of IL-7 responsiveness and gene expression during commitment of bipotent B-cell/macrophage progenitors

1996 • 26 citations

Common Lymphoid Progenitors, Early B-Lineage Precursors, and IL-7: Characterizing the Trophic and Instructive Signals Underlying Early B Cell Development

2003 • 22 citations

In interleukin‐7‐transgenic mice, increasing B lymphopoiesis increases follicular but not marginal zone B cell numbers

2003 • 20 citations

EXOGENOUS INTERLEUKIN 7 AS A PROLIFERATIVE STIMULANT OF EARLY PRECURSOR B CELLS IN MOUSE BONE MARROW: EFFICACY OF IL-7 INJECTION, IL-7 INFUSION AND IL-7–ANTI-IL-7 ANTIBODY COMPLEXES

1998 • 17 citations

Activation of the Recombination Activating Gene 1 (RAG-1) Transcript in Bone Marrow of Senescent C57BL/6 Mice by Recombinant Interleukin-7

1999 • 11 citations