Inhibition of B Cell Death Causes the Development of an IgA Nephropathy in (New Zealand White × C57BL/6)F1-bcl-2 Transgenic Mice

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

The 1996 Guide for the Care and Use of Laboratory Animals

1997 • 1,385 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

Origins and Functions of B-1 Cells with Notes on the Role of CD5

2002 • 752 citations

IgA Nephropathy

2002 • 609 citations

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

2002 • 564 citations

Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies

1999 • 455 citations

Predicting renal outcome in IgA nephropathy.

1997 • 427 citations

TGF-β Receptor Controls B Cell Responsiveness and Induction of IgA In Vivo

2000 • 403 citations

Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG

1997 • 297 citations

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions

1999 • 291 citations

Functional dissection of systemic lupus erythematosus using congenic mouse strains.

1997 • 268 citations

Fcα Receptor (Cd89) Mediates the Development of Immunoglobulin a (Iga) Nephropathy (Berger's Disease)

1999 • 238 citations

IgA production without μ or δ chain expression in developing B cells

2001 • 223 citations

IgA Nephropathy

2000 • 191 citations

Evidence for genetic factors in the development and progression of IgA nephropathy

2000 • 168 citations

Genetic dissection of systemic lupus erythematosus

1999 • 158 citations

Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice.

1996 • 122 citations

Underglycosylation of IgA1 Hinge Plays a Certain Role for Its Glomerular Deposition in IgA Nephropathy

1999 • 121 citations

Unresponsiveness to Lymphoid-Mediated Signals at the Neonatal Follicular Dendritic Cell Precursor Level Contributes to Delayed Germinal Center Induction and Limitations of Neonatal Antibody Responses to T-Dependent Antigens

2003 • 112 citations

bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation

1996 • 112 citations

Deficient IgA1 immune response to nasal cholera toxin subunit B in primary IgA nephropathy

1996 • 99 citations

Immunoglobulin A nephropathy

1997 • 96 citations

The glycosylation of IgA produced by murine B cells is altered by Th2 cytokines.

1997 • 92 citations

Enhanced production of glomerular extracellular matrix in a new mouse strain of high serum IgA ddY mice

1996 • 83 citations

Removal systems of immunoglobulin A and immunoglobulin A containing complexes in IgA nephropathy and cirrhosis patients. The role of asialoglycoprotein receptors.

1993 • 82 citations

Induction of immunoglobulin synthesis by CD4+ T cell clones

1993 • 77 citations

Structural changes in the oligosaccharide chains of IgG in autoimmune MRL/Mp-lpr/lpr mice.

1990 • 74 citations

Glycosylation of IgG, immune complexes and IgG subclasses in the MRL‐lpr/lpr mouse model of rheumatoid arthritis

1990 • 67 citations

T cell cytokines determine the severity of experimental IgA nephropathy by regulating IgA glycosylation

2001 • 64 citations

Alterations in the IgA Carbohydrate Chains Influence the Cellular Distribution of IgA11

2015 • 53 citations

B Cell–specific Transgenic Expression of Bcl2 Rescues Early B Lymphopoiesis but Not B Cell Responses in BOB.1/OBF.1-deficient Mice

2003 • 47 citations

Increased and prolonged production of specific polymeric IgA after systemic immunization with tetanus toxoid in IgA nephropathy

1992 • 46 citations

Control of separate pathogenic autoantibody responses marks MHC gene contributions to murine lupus

1999 • 44 citations

Unexpected Autoantibody Production in Membrane Ig-μ-Deficient/lprMice

2000 • 44 citations

Effect of Long-Term Anti-CD4 or Anti-CD8 Treatment on the Development of lpr CD4 − CD8 − Double Negative T Cells and of the Autoimmune Syndrome in MRL- lpr / lpr Mice

1995 • 41 citations

Constitutive expression of bcl-2 in B cells causes a lethal form of lupuslike autoimmune disease after induction of neonatal tolerance to H-2b alloantigens.

1996 • 39 citations

Increased IgA‐producing cells in the blood of patients with active henoch‐schönlein purpura

1983 • 39 citations

Continued differentiation during B lymphopoiesis requires signals in addition to cell survival

1997 • 38 citations

Increase in tonsillar germinal centre B-1 cell numbers in IgA nephropathy (IgAN) patients and reduced susceptibility to Fas-mediated apoptosis

2001 • 38 citations

Interleukin-12 alters the physicochemical characteristics of serum and glomerular IgA and modifies glycosylation in a ddY mouse strain having high IgA levels

2002 • 34 citations

Investigation of the Structural Heterogeneity in the Carbohydrate Portion of a Mouse Monoclonal Immunoglobulin A Antibody

1993 • 25 citations

Spontaneous production of anti‐mouse red blood cell autoantibodies is independent of the polyclonal activation in NZB mice

1990 • 20 citations

Autoimmune Lymphoproliferative Syndrome: Types I, II and Beyond

2001 • 20 citations

Immunoglobulin-Producing Cells in IgA Nephropathy

1986 • 14 citations

Enforced Bcl‐2 expression in B lymphocytes induces rheumatoid factor and anti‐DNA production, but the Yaa mutation promotes only anti‐DNA production

2004 • 7 citations