Mechanisms of Intralysosomal Degradation with Special Reference to Autophagocytosis and Heterophagocytosis of Cell Organelles

The Fluid Mosaic Model of the Structure of Cell Membranes

1972 • 8,835 citations

Intracellular Aspects of the Process of Protein Synthesis

1975 • 3,560 citations

Functions of Lysosomes

1966 • 2,942 citations

Lysosomes in biology and pathology

1977 • 2,068 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells: Part 2

1976 • 1,060 citations

LYSOSOME FUNCTION IN THE REGULATION OF THE SECRETORY PROCESS IN CELLS OF THE ANTERIOR PITUITARY GLAND

1966 • 951 citations

Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm.

1975 • 916 citations

CYTOPLASMIC COMPONENTS IN HEPATIC CELL LYSOSOMES

1962 • 803 citations

PROTEIN DEGRADATION IN CULTURED CELLS

1974 • 603 citations

GOLGI APPARATUS, GERL, AND LYSOSOMES OF NEURONS IN RAT DORSAL ROOT GANGLIA, STUDIED BY THICK SECTION AND THIN SECTION CYTOCHEMISTRY

1971 • 583 citations

BIOGENESIS OF ENDOPLASMIC RETICULUM MEMBRANES

1966 • 581 citations

Studies on the Synthesis and Degradation of Proteins of the Endoplasmic Reticulum of Rat Liver

1969 • 538 citations

INFLUENCE OF GLUCAGON, AN INDUCER OF CELLULAR AUTOPHAGY, ON SOME PHYSICAL PROPERTIES OF RAT LIVER LYSOSOMES

1967 • 509 citations

Turnover of Constituents of the Endoplasmic Reticulum Membranes of Rat Hepatocytes

1967 • 484 citations

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

1979 • 466 citations

Lysosomes: A laboratory handbook

1978 • 367 citations

Transport of proteins into mitochondria and chloroplasts.

1979 • 355 citations

Structural aspects of the membrane of the endoplasmic reticulum

1975 • 351 citations

Inhibition by Insulin of Valine Turnover in Liver

1970 • 338 citations

The liver cell

1960 • 329 citations

Studies on cellular autophagocytosis. The formation of autophagic vacuoles in the liver after glucagon administration.

1968 • 328 citations

Induction of autophagy by amino-acid deprivation in perfused rat liver

1977 • 323 citations

Studies on the mechanism of phagocytosis. II. The interaction of macrophages with anti-immunoglobulin IgG-coated bone marrow-derived lymphocytes.

1976 • 296 citations

Observations on the fine structure and peroxidase cytochemistry of normal rat liver Kupffer cells

1974 • 293 citations

Proteins of Iron Storage and Transport in Biochemistry and Medicine

1976 • 288 citations

Protein Turnover and Lysosome Function

1978 • 279 citations

Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy.

1978 • 276 citations

Leupeptin, a Protease Inhibitor, Decreases Protein Degradation in Normal and Diseased Muscles

1978 • 267 citations

Digestive Activity of Lysosomes

1968 • 254 citations

A MORPHOMETRIC STUDY OF THE REMOVAL OF PHENOBARBITAL-INDUCED MEMBRANES FROM HEPATOCYTES AFTER CESSATION OF TREATMENT

1973 • 250 citations

Digestive Activity of Lysosomes

1969 • 246 citations

TEMPORAL CHANGES IN <scp>P</scp>H WITHIN THE PHAGOCYTIC VACUOLE OF THE POLYMORPHONUCLEAR NEUTROPHILIC LEUKOCYTE

1973 • 241 citations

Selective control of the degradation of normal and aberrant proteins in Reuber H35 hepatoma cells

1976 • 234 citations

Effects of Phenobarbital on the Synthesis and Degradation of the Protein Components of Rat Liver Microsomal Membranes

1969 • 223 citations

Digestive Activity of Lysosomes

1968 • 219 citations

Inhibition of protein degradation in isolated rat hepatocytes

1977 • 214 citations

Direct evidence of importance of lysosomes in degradation of intracellular proteins

1975 • 209 citations

Lipid composition and turnover of rough and smooth microsomal membranes in rat liver

1968 • 201 citations

The permeability properties of the lysosomal membrane

1977 • 198 citations

Size Distribution of Membrane Proteins of Rat Liver and Their Relative Rates of Degradation

1971 • 192 citations

Suppression of Protein Turnover by Amino Acids in the Perfused Rat Liver

1972 • 190 citations

CYTOLOGICAL STUDIES ON TWO FUNCTIONAL HEPATOMAS

1962 • 189 citations

Purification by Means of Detergents and Properties of Cytochrome b5 from Liver Microsomes

1968 • 185 citations

ENZYME-MEMBRANE RELATIONSHIP IN PHENOBARBITAL INDUCTION OF SYNTHESIS OF DRUG-METABOLIZING ENZYME SYSTEM AND PROLIFERATION OF ENDOPLASMIC MEMBRANES

1966 • 176 citations

LOCALIZATION OF ACID PHOSPHATASE IN LIPOFUSCIN GRANULES AND POSSIBLE AUTOPHAGIC VACUOLES IN INTERSTITIAL CELLS OF THE GUINEA PIG TESTIS

1968 • 172 citations

Studies on the Correlation between Size and Relative Degradation Rate of Soluble Proteins

1973 • 165 citations

On the Measurement of Protein Turnover in Animal Cells

1972 • 162 citations

The Kinetics of Disappearance of Labeled Leucine from the Free Leucine Pool and Rat Liver and Its Effect on the Apparent Turnover of Catalase and Other Hepatic Proteins

1971 • 158 citations

CYTOLYSOMES IN METABOLICALLY ACTIVE CELLS

1963 • 156 citations

Studies on the synthesis and intracellular transport of lipoprotein particles in rat liver.

1975 • 152 citations

Role of changes in protein degradation in the growth of regenerating livers.

1976 • 150 citations

Electron microscopical studies on rat brain neurons. Localization of acid phosphatase and mode of formation of lipofuscin bodies

1972 • 146 citations

Fate of plasma membrane during endocytosis. II. Evidence for recycling (shuttle) of plasma membrane constituents

1979 • 145 citations

An electron microscopic study of early cytoplasmic alterations in hepatic parenchymal cells of mouse liver during necrosis in vitro (autolysis).

1962 • 140 citations

ELECTRON MICROSCOPIC STUDIES OF THE PROXIMAL TUBULE OF THE RAT KIDNEY. II. CYTOSEGRESOMES AND CYTOSOMES: THEIR RELATIONSHIP TO EACH OTHER AND TO THE LYSOSOME CONCEPT.

1965 • 140 citations

Studies on mammary gland involution

1968 • 136 citations

The Proximal Tubule Cell in Experimental Hydronephrosis

1959 • 135 citations

Lysosomal Lipases of Rat Liver and Kidney

1968 • 134 citations

ULTRASTRUCTURAL CHANGES IN REGRESSING TAIL MUSCLES OF XENOPUS LARVAE AT METAMORPHOSIS

1964 • 134 citations

Observations on the application to electron microscopy of the lead phosphate technique for the demonstration of acid phosphatase

1965 • 125 citations

Synthesis and Turnover of Membrane Proteins in Rat Liver: An Examination of the Membrane Flow Hypothesis

1971 • 117 citations

Effect of microtubular or translational inhibitors on general cell protein degradation. Evidence for a dual catabolic pathway

1977 • 110 citations

A morphometric study of cellular autophagy including diurnal variations in kidney tubules of normal rats.

1975 • 108 citations

Studies on induced cellular autophagy

1969 • 108 citations

Alterations of lysosomal size and density during rat liver perfusion. Suppression by insulin and amino acids.

1977 • 106 citations

Studies on induced cellular autophagy

1969 • 102 citations

QUANTITATIVE CHARACTERIZATION OF DENSE BODY, AUTOPHAGIC VACUOLE, AND ACID PHOSPHATASE-BEARING PARTICLE POPULATIONS DURING THE EARLY PHASES OF GLUCAGON-INDUCED AUTOPHAGY IN RAT LIVER

1971 • 98 citations

ELECTRON MICROSCOPIC STUDIES OF THE EPITHELIUM OF THE PROXIMAL TUBULE OF THE RAT KIDNEY. I. THE INTRACELLULAR LOCALIZATION OF ACID PHOSPHATASE.

1964 • 97 citations

A statistical analysis of the relationship between degradative rates and molecular weights of proteins

1975 • 97 citations

Studies on mammary gland involution

1968 • 90 citations

Evidence for an ATP-driven “proton pump” in rat liver lysosomes by basic dyes uptake

1979 • 89 citations

Solubilization of NADH-cytochrome b5 Reductase from Liver Microsomes by Lysosomal Digestion

1970 • 86 citations

EFFECTS OF ARGININE DEPRIVATION, ULTRAVIOLET RADIATION, AND X-RADIATION ON CULTURED KB CELLS

1965 • 86 citations

Osmotic alterations of the lysosomal system during rat liver perfusion: Reversible suppression by insulin and amino acids

1974 • 85 citations

Relationship between medium pH and that of the lysosomal matrix as studied by two independent methods

1976 • 84 citations

Ion distribution in lysosomal suspensions

1973 • 83 citations

Measurement of protein turnover in rat liver. Analysis of the complex curve for decay of label in a mixture of proteins

1976 • 80 citations

THE EFFECTS OF A DIET PRODUCING LIPOCHROME PIGMENT (CEROID) ON THE ULTRASTRUCTURE OF SKELETAL MUSCLE IN THE RAT.

1964 • 80 citations

Observations on the subcellular organization of hepatic parenchymal cells. II. Evolution of reversible alterations induced by hypoxia.

1966 • 78 citations

Relationship between Degradation Rates of Proteins in Vivo and Their Susceptibility to Lysosomal Proteases

1974 • 77 citations

Physicochemical modifications of lysosomal hydrolases during intracellular transport

1973 • 73 citations

Studies of cellular injury in isolated flounder tubules. I. Correlation between morphology and function of control tubules and observations of autophagocytosis and mechanical cell damage.

1967 • 71 citations

CYTOPLASMIC BODIES CONTAINING MITOCHONDRIA, RIBOSOMES, AND ROUGH SURFACED ENDOPLASMIC MEMBRANES IN THE EPITHELIUM OF THE SMALL INTESTINE OF NEWBORN RATS

1962 • 70 citations

Endoplasmic reticulum and autophagy in rat hepatocytes.

1978 • 69 citations

Hepatic Autophagy in Uncontrolled Experimental Diabetes and Its Relationships to Insulin and Glucagon

1974 • 68 citations

Electron microscopic studies of the epithelium of the proximal tubule of the rat kidney. 3. Microbodies, multivesicular bodies, and the golgi apparatus.

1966 • 68 citations

Regulation of the Transport and Metabolism of Amino Acids in Isolated Fat Cells

1970 • 66 citations

Concerning a possible mechanism for selective capture of cytoplasmic proteins by lysosomes

1975 • 64 citations

A comparison of the proteolytic susceptibility of several rat liver enzymes

1971 • 63 citations

LYSOSOMAL CHANGES IN RAT HEPATIC PARENCHYMAL CELLS AFTER GLUCAGON ADMINISTRATIONI

1974 • 63 citations

EFFECTS OF CONCANAVALIN A ON MOUSE PERITONEAL MACROPHAGES

1974 • 62 citations

Protein Catabolism in Rat Liver Homogenates

1970 • 62 citations

Increased degradation in rat liver induced by vinblastine. I. Biochemical characterization.

1980 • 55 citations

Rapid postsynthetic destruction of unstable haemoglobin Bushwick

1975 • 55 citations

Studies of necrosis in vitro of mouse hepatic parenchymal cells. Ultrastructural and cytochemical alterations of cytosomes, cytosegresomes, multivesicular bodies, and microbodies and their relation to the lysosome concept.

1965 • 54 citations

Lysosomal sequestration of intracellular protein as a regulatory step in hepatic proteolysis.

1977 • 53 citations

Effect of ATP on Protein Degradation in Rat Liver Lysosomes

1973 • 50 citations

A correlation between turnover rates and lipophilic affinities of soluble rat liver proteins

1976 • 47 citations

Studies on cellular autophagocytosis. The relationship of autophagocytosis to protein synthesis and to energy metabolism in rat liver and flounder kidney tubules in vitro.

1973 • 47 citations

Studies on mammary gland involution

1968 • 46 citations

Autolysis of glycoproteins in rat kidney lysosomes in vitro. Effects on the isoelectric focusing behaviour of glycoproteins, arylsulphatase and β-glucuronidase

1974 • 46 citations

Degradation of Nucleic Acids by Lysosomal Extracts of Rat Liver and Ehrlich Ascites Tumor Cells

1970 • 45 citations

Cytomegalovirus: development and progression of cytopathic effects in human cell culture.

1980 • 44 citations

Role of golgi apparatus in the formation of cytolysomes

1964 • 44 citations

In vitro uptake of particles by lysosomes

1980 • 44 citations

Autophagic degradation in rat liver after vinblastine treatment

1980 • 43 citations

Autophagocytosis: Origin of membrane and hydrolytic enzymes

1969 • 41 citations

Inhibitor of protein degradation formed during incubation of isolated rat hepatocytes in a cell culture medium

1977 • 41 citations

Effect of ionophores and temperature on intralysosomal pH

1975 • 40 citations

The acidification of rat liver lysosomes in vitro: A role for the membranous ATPase as a proton pump

1979 • 37 citations

The relative stability of liver cytosol enzymes incubated in vitro

1974 • 36 citations

Distribution and shifts of ingested marker particles in residual bodies and other lysosomes

1973 • 35 citations

INTERACTIONS OF MACROPHAGES AND ERYTHROCYTES.

1964 • 33 citations

Lysosomal degradation of cell organelles. I. Ultrastructural analysis of uptake and digestion of intravenously injected mitochondria by Kupffer cells.

1975 • 32 citations

Phagocytosis and degradation of rat liver mitochondria by cultivated human glial cells.

1980 • 30 citations

ELECTRON MICROSCOPIC AND CYTOCHEMICAL STUDIES OF ACID PHOSPHATASE AND ARYL SULFATASE DURING AUTOLYSIS

1967 • 29 citations

Observations on the subcellular organization of hepatic parenchymal cells. I. Golgi apparatus, cytosomes, and cytosegresomes in normal cells.

1966 • 29 citations

Method for the isolation of iron‐loaded lysosomes from rat liver

1973 • 28 citations

Fate of surface proteins of rabbit polymorphonuclear leukocytes during phagocytosis. II. Internalization of proteins.

1979 • 27 citations

Lysosomal degradation of cell organelles. III. Uptake and disappearance in Kupffer cells of intravenously injected isotope-labeled mitochondria and microsomes in vivo and in vitro.

1975 • 26 citations

Isolation of liver lysosomes by iron loading. Ultrastructural characterization.

1975 • 25 citations

Autophagocytosis in mouse seminal vesicle cells in vitro

1980 • 24 citations

Effect of cycloheximide on glucagon-induced autophagy. Quantitative examinations on hepatocytes in the rat.

1978 • 22 citations

Cytochrome P-450 linked mixed function oxidase turnover of microsomal components and effects of inducers on the turnover phospholipids, proteins and specific enzymes

1980 • 21 citations

Different Turnover Behavior of Phenobarbital-induced and Normal NADPH-Cytochrome c Reductases in Rat Liver Microsomes

1971 • 19 citations

Effects of in vivo liver ischemia on microsomes and lysosomes

1981 • 18 citations

Proteolysis at neutral pH in a lysosomal‐cytosol system can not be attributed to the uptake of proteins into lysosomes

1974 • 16 citations

Lysosomal degradation of cell organelles

1976 • 8 citations

Induction of liver lysosomal enzymes during the autophagic phase following phenobarbital treatment of rat

1977 • 7 citations

Uptake and degradation of glycogen by Kupffer cells

1979 • 7 citations

Effect of storage and in vitro ischemia on the ultrastructure of microsomal membranes and on microsomal enzymes

1976 • 3 citations