Aspartic Acid 26 in Reduced Escherichia coli Thioredoxin Has a pKa >9

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

The interpretation of protein structures: Estimation of static accessibility

1971 • 5,771 citations

MUTANTS OF ESCHERICHIA COLI REQUIRING METHIONINE OR VITAMIN B ₁₂

1950 • 2,926 citations

Solvent-Accessible Surfaces of Proteins and Nucleic Acids

1983 • 2,685 citations

Correlation of proton and nitrogen-15 chemical shifts by multiple quantum NMR

1983 • 1,262 citations

Identification of a protein required for disulfide bond formation in vivo

1991 • 967 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin

1985 • 622 citations

Crystal structure of thioredoxin from Escherichia coli at 1.68 Å resolution

1990 • 568 citations

Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin

1993 • 490 citations

Conformational stability and activity of ribonuclease T1 with zero, one, and two intact disulfide bonds.

1988 • 445 citations

Crystal structure of the DsbA protein required for disulphide bond formation in vivo

1993 • 387 citations

Structural and functional relations among thioredoxins of different species

1991 • 363 citations

Thioredoxin. 6. The Amino Acid Sequence of the Protein from Escherichia coli B

1968 • 274 citations

High-resolution solution structures of oxidized and reduced Escherichia coli thioredoxin

1994 • 261 citations

Reactivity and Ionization of the Active Site Cysteine Residues of DsbA, a Protein Required for Disulfide Bond Formation in vivo

1994 • 239 citations

Reactive oxygen-reducing and protein-refolding activities of adult t cell leukemia-derived factor /human thioredoxin

1992 • 176 citations

Interaction of mutant thioredoxins of Escherichia coli with the gene 5 protein of phage T7. The redox capacity of thioredoxin is not required for stimulation of DNA polymerase activity.

1986 • 146 citations

The high-resolution three-dimensional solution structures of the oxidized and reduced states of human thioredoxin

1994 • 143 citations

Thioredoxin or glutaredoxin in Escherichia coli is essential for sulfate reduction but not for deoxyribonucleotide synthesis

1990 • 135 citations

Individual Ionization Constants of All the Carboxyl Groups in Ribonuclease HI from Escherichia coli Determined by NMR

1994 • 135 citations

Thioredoxin is required for filamentous phage assembly.

1985 • 131 citations

Isomers in Thioredoxins of Spinach Chloroplasts

1981 • 118 citations

Urea dependence of thiol-disulfide equilibria in thioredoxin: confirmation of the linkage relationship and a sensitive assay for structure

1989 • 115 citations

The Redox Properties of Protein Disulfide Isomerase (DsbA) of Escherichia coli Result from a Tense Conformation of its Oxidized Form

1993 • 112 citations

The conserved, buried aspartic acid in oxidized Escherichia coli thioredoxin has a pKa of 7.5. Its titration produces a related shift in global stability

1991 • 111 citations

Regulation of NADP‐malate dehydrogenase by the light‐actuated ferredoxin/thioredoxin system of chloroplasts

1977 • 110 citations

Relationship between electrostatics and redox function in human thioredoxin: characterization of pH titration shifts using two-dimensional homo- and heteronuclear NMR

1992 • 109 citations

Assignment of the backbone proton and nitrogen-15 NMR resonances of bacteriophage T4 lysozyme

1990 • 85 citations

Determination of the pKa values of active-center cysteines, cysteines-32 and -35, in Escherichia coli thioredoxin by Raman spectroscopy

1993 • 80 citations

Linkage of thioredoxin stability to titration of ionizable groups with perturbed pKa

1991 • 70 citations

Construction and characterization of glutaredoxin-negative mutants of Escherichia coli.

1988 • 67 citations

A Thioredoxin Induced by Bacteriophage T4

1970 • 65 citations

Mutation of conserved residues in Escherichia coli thioredoxin: Effects on stability and function

1992 • 65 citations

Proton-transfer effects in the active-site region of Escherichia coli thioredoxin using two-dimensional proton NMR

1991 • 64 citations

Equilibrium and kinetic measurements of the conformational transition of reduced thioredoxin

1987 • 56 citations

Escherichia coli thioredoxin folds into two compact forms of different stability to urea denaturation

1989 • 48 citations

Characterization by ¹H NMR of a C32S,C35S double mutant of Escherichia coli thioredoxin confirms its resemblance to the reduced wild‐type protein

1994 • 22 citations

Escherichia coli glutaredoxin: cloning and overexpression, thermodynamic stability of the oxidized and reduced forms, and report of an N-terminal extended species

1991 • 21 citations

EFFECT OF ESCHERICHIA-COLI THIOREDOXIN, A HOMOLOG TO THE ADULT T-CELL LEUKEMIA-DERIVED FACTOR, ON EPSTEIN-BARR VIRUS-TRANSFORMED B-LYMPHOCYTES

1994 • 3 citations