Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments

Arzneimittelforschung

2012 • 3,595 citations

Antidepressant effects of ketamine in depressed patients

2000 • 3,482 citations

Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans

1994 • 3,182 citations

Subgenual prefrontal cortex abnormalities in mood disorders

1997 • 2,646 citations

Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness

1999 • 2,351 citations

Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders

2000 • 1,927 citations

Hippocampal atrophy in recurrent major depression.

1996 • 1,884 citations

Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex

1997 • 1,743 citations

Hippocampal Volume Reduction in Major Depression

2000 • 1,645 citations

Glial reduction in the subgenual prefrontal cortex in mood disorders

1998 • 1,497 citations

Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.

1999 • 1,450 citations

A functional anatomical study of unipolar depression

1992 • 1,266 citations

Energy on Demand

1999 • 1,162 citations

A Double-Blind Placebo-Controlled Study of Lamotrigine Monotherapy in Outpatients With Bipolar I Depression

1999 • 1,056 citations

Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

1998 • 1,002 citations

Study of a New Schizophrenomimetic Drug—Sernyl

1959 • 922 citations

Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain

1993 • 892 citations

Neural plasticity to stress and antidepressant treatment

1999 • 638 citations

History and evolution of the monoamine hypothesis of depression.

2000 • 634 citations

Reduced Cortical γ-Aminobutyric Acid Levels in Depressed Patients Determined by Proton Magnetic Resonance Spectroscopy

1999 • 610 citations

Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study

2000 • 567 citations

Prefrontal Cortical‐Amygdalar Metabolism in Major Depression

1999 • 548 citations

Serotonin model of schizophrenia: emerging role of glutamate mechanisms

2000 • 520 citations

5-Hydroxytryptamine _2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites

1998 • 510 citations

Prefrontal cortex regulates inhibition and excitation in distributed neural networks

1999 • 505 citations

Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.

1993 • 495 citations

Molecular Neurobiology for Practicing Psychiatrists, Part 5: How a Leucine Zipper Can Turn On Genes: Immediate-Early Genes Activate Late-Gene Expression in the Brain.

2000 • 492 citations

NMDA-dependent modulation of CA1 local circuit inhibition

1996 • 481 citations

The role of glutamate in epilepsy and other CNS disorders.

1994 • 476 citations

Long Term Lithium Treatment Suppresses p53 and Bax Expression but Increases Bcl-2 Expression

1999 • 470 citations

Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: common adaptations among cross-sensitizing agents

1996 • 454 citations

Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo ¹³ C NMR

1999 • 445 citations

Ketamine activates psychosis and alters limbic blood flow in schizophrenia

1995 • 438 citations

Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N -methyl- <scp>d</scp> -aspartate receptor-mediated calcium influx

1998 • 422 citations

Attenuation of the Neuropsychiatric Effects of Ketamine With Lamotrigine

2000 • 418 citations

d-Serine as a Neuromodulator: Regional and Developmental Localizations in Rat Brain Glia Resemble NMDA Receptors

1997 • 410 citations

Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers

1997 • 393 citations

Differential psychopathology and patterns of cerebral glucose utilisation produced by (S)- and (R)-ketamine in healthy volunteers using positron emission tomography (PET)

1997 • 388 citations

Brain-Derived Neurotrophic Factor Mediates the Activity-Dependent Regulation of Inhibition in Neocortical Cultures

1997 • 385 citations

Hippocampal volume in geriatric depression

2000 • 371 citations

GABA and mood disorders: a brief review and hypothesis

1995 • 370 citations

Progesterone metabolite allopregnanolone in women with premenstrual syndrome

1997 • 350 citations

Adaptation of N-Methyl-D-Aspartate (NMDA) Receptors following Antidepressant Treatment: Implications for the Pharmacotherapy of Depression

1996 • 341 citations

Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents — preclinical studies

1997 • 317 citations

Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR

1995 • 304 citations

Rostral and Orbital Prefrontal Cortex Dysfunction in the Manic State of Bipolar Disorder

1999 • 290 citations

The effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy

1996 • 286 citations

Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex.

2000 • 275 citations

Increased anterior cingulate and caudate activity in bipolar mania

2000 • 274 citations

Alterations in the N-methyl-d-asparatate (NMDA) receptor complex in the frontal cortex of suicide victims

1995 • 263 citations

Reductions in Occipital Cortex GABA Levels in Panic Disorder Detected With 1H-Magnetic Resonance Spectroscopy

2001 • 255 citations

Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness

1999 • 247 citations

Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.

1994 • 241 citations

Mechanism of Disinhibition After Brain Lesions

1997 • 231 citations

Anticonvulsant and antidepressant properties of electroconvulsive therapy: a proposed mechanism of action.

1983 • 208 citations

MOLECULAR BIOLOGY OF MAMMALIAN AMINO ACID TRANSPORTERS

1996 • 205 citations

The Relationship Between Panic Disorder and Major Depression

1993 • 200 citations

Tricyclic antidepressants block N‐methyl‐D‐aspartate receptors: similarities to the action of zinc

1988 • 189 citations

Allopregnanolone concentrations and premenstrual syndrome

2000 • 186 citations

Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans

1998 • 185 citations

PHENOTHIAZINE PIGMENTATION

1965 • 179 citations

Circulating levels of anxiolytic steroids in the luteal phase in women with premenstrual syndrome and in control subjects.

1994 • 178 citations

Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: therapeutic implications.

1999 • 168 citations

The anticonvulsant, lamotrigine decreases spontaneous glutamate release but increases spontaneous GABA release in the rat entorhinal cortex in vitro

2000 • 158 citations

Low brain GABA level is associated with poor seizure control

1996 • 157 citations

Lithium acutely inhibits and chronically up-regulates and stabilizes glutamate uptake by presynaptic nerve endings in mouse cerebral cortex

1998 • 149 citations

DOI-Induced Activation of the Cortex: Dependence on 5-HT_2AHeteroceptors on Thalamocortical Glutamatergic Neurons

2000 • 149 citations

Role of 5-HT2A receptors in the stress-induced down-regulation of brain-derived neurotrophic factor expression in rat hippocampus

1999 • 139 citations

Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N‐methyl‐D‐aspartate receptor.

1990 • 139 citations

Depression Among Alcoholics

1991 • 136 citations

Similar potency of carbamazepine, oxcarbazepine, and lamotrigine in inhibiting the release of glutamate and other neurotransmitters

1995 • 134 citations

Impairment of GABAergic Transmission in Depression: New Insights from Neuroimaging Studies

2000 • 133 citations

Memantine in the treatment of mild to moderate dementia syndrome. A double-blind placebo-controlled study.

1992 • 121 citations

CYLOSERINE AS AN ANTIDEPRESSANT AGENT

1959 • 121 citations

Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy

1999 • 118 citations

Systemic PCP treatment elevates brain extracellular 5-HT

1998 • 117 citations

A comparison of trazodone and fluoxetine: implications for a serotonergic mechanis of antidepressant action

1992 • 115 citations

GABAergic modulation of learned helplessness

1981 • 115 citations

Therapeutic brain concentration of the NMDA receptor antagonist amantadine

1995 • 109 citations

Comparative Patch‐clamp Studies with Freshly Dissociated Rat Hippocampal and Striatal Neurons on the NMDA Receptor Antagonistic Effects of Amantadine and Memantine

1996 • 107 citations

Characterization df a [³H]Glycine Recognition Site as a Modulatory Site of the N‐Methyl‐D‐Aspartate Receptor Complex

1989 • 106 citations

Actions of ?-cycloserine at the ? glycine receptor site in vivo

1991 • 105 citations

Antipsychotics in the treatment of mood disorders and risk of tardive dyskinesia.

2000 • 104 citations

Different mechanisms of protection against apoptosis by valproate and Li⁺

1999 • 103 citations

A Naturalistic Comparison of Clozapine, Risperidone, and Olanzapine in the Treatment of Bipolar Disorder

2000 • 101 citations

The gabaergic hypothesis of depression

1989 • 100 citations

Adjunctive treatment of manic agitation with lorazepam versus haloperidol: a double-blind study.

1992 • 98 citations

Allopregnanolone in Women with Premenstrual Syndrome

1998 • 96 citations

Possible Use of Amantadine in Depression

1999 • 94 citations

Human brain GABA levels rise rapidly after initiation of vigabatrin therapy

1996 • 93 citations

Measuring human brain GABA in vivo

1998 • 92 citations

Molecular Mechanisms Underlying Mood Stabilization in Manic-Depressive Illness: The Phenotype Challenge

1999 • 90 citations

Effect of carbamazepine, oxcarbazepine and lamotrigine on the increase in extracellular glutamate elicited by veratridine in rat cortex and striatum

1996 • 77 citations

Double-Blind Comparison of the Effects of Clonazepam and Lorazepam in Acute Mania

1990 • 75 citations

AMANTADINE DOSAGE IN TREATMENT OF PARKINSON'S DISEASE

1970 • 74 citations

Reliability of a lifetime history of major depression: implications for heritability and co-morbidity

1998 • 72 citations

Effects of anticonvulsants on veratridine- and KCl-evoked glutamate release from rat cortical synaptosomes

1999 • 69 citations

An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons

1999 • 69 citations

Kinetic study of the interactions between the glutamate and glycine recognition sites on the N-methyl-D-aspartic acid receptor complex.

1994 • 65 citations

Pathophysiology of Secondary Depressions in the Elderly

1999 • 62 citations

AMANTADINE IN DEPRESSION

1971 • 60 citations

Biology of schizophrenia and affective disease

1997 • 58 citations

Attenuation of Ketamine Effects by Nimodipine Pretreatment in Recovering Ethanol Dependent Men Psychopharmacologic Implications of the Interaction of NMDA and L-Type Calcium Channel Antagonists

2001 • 56 citations

New evidence for the antidepressant activity of MK-801, a non-competitive antagonist of NMDA receptors.

1993 • 53 citations

The psychotropic effects of cycloserine: A new use for an antibiotic

1961 • 53 citations

Treatment of Impaired Cerebral Function in Psychogeriatric Patients with Memantine - Results of a Phase II Double-Blind Study

1988 • 50 citations

Dr. Zubenko Replies

1984 • 48 citations

Clonidine in the treatment of mania and mixed bipolar disorder

1984 • 43 citations

Swim Stress Increases the Potency of Glycine at the N‐Methyl‐<scp>d</scp>‐Aspartate Receptor Complex

1995 • 43 citations

The effect of repeated electroconvulsive shock on GABA synthesis and release in regions of rat brain

1987 • 40 citations

Single doses of MK-801, a non-competitive antagonist of NMDA receptors, increase the number of 5-HT1A serotonin receptors in the rat brain

1997 • 39 citations

CLINICAL STUDIES OF INDUCTION AGENTS XXXVIII: EFFECT OF PREMEDICANTS AND SUPPLEMENTS ON KETAMINE ANAESTHESIA

1971 • 32 citations

N-Methyl-d-aspartate receptors regulate 5-HT release in the raphe nuclei and frontal cortex of freely moving rats: differential role of 5-HT1A autoreceptors

1998 • 31 citations

Blockade of transmission at NMDA receptors facilitates the electrical and synthetic activity of ascending serotoninergic neurones

1994 • 30 citations

Comparison of clonidine and lithium in the treatment of mania

1986 • 23 citations

Inhibition of N-methyl-l-aspartate activated ion current by desmethylimipramine

1990 • 18 citations

Rapid down-regulation of beta-adrenergic receptors evoked by combined forced swimming test and CGP 37849--a competitive antagonist of NMDA receptors.

1995 • 14 citations

304. Cortical GABA reduced in unipolar but not bipolar depression

2000 • 11 citations

Amantadine-induced aggressiveness.

1972 • 5 citations

The neuropharmacological effects of electroconvulsive shock and their relationship to the therapeutic effect of electroconvulsive therapy in depression.

1984 • 4 citations

1. ECT Effects on Cortical GABA Levels as Determined by 1H-MRS

1999 • 4 citations

Blockade of ketamine-induced psychosis: A human model for a new spectrum of antipsychotic activity?

2000 • 1 citations