Association of the Glu298Asp Polymorphism in the Endothelial Nitric Oxide Synthase Gene with Essential Hypertension Resistant to Conventional Therapy
Data up to Jan 2025
Total Citations Per Year
Abstract
References (42)
The Porphyrin Handbook
2003 • 2,610 citations
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase
1991 • 2,371 citations
Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
1998 • 1,475 citations
ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM
1987 • 1,450 citations
Nitric oxide : biology and pathobiology
2000 • 1,296 citations
Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene
1993 • 881 citations
T −786 →C Mutation in the 5′-Flanking Region of the Endothelial Nitric Oxide Synthase Gene Is Associated With Coronary Spasm
1999 • 774 citations
NITRIC OXIDE SYNTHASE: Role in the Genesis of Vascular Disease
1997 • 719 citations
Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.
1992 • 616 citations
Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase
1998 • 610 citations
Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.
1997 • 585 citations
A smoking–dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene
1996 • 571 citations
Endothelial Nitric Oxide Synthase Gene Is Positively Associated With Essential Hypertension
1998 • 530 citations
Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: Cleavage of proteins with aspartate vs. glutamate at position 298
2000 • 527 citations
A Common Variant of the Endothelial Nitric Oxide Synthase (Glu 298 →Asp) Is a Major Risk Factor for Coronary Artery Disease in the UK
1999 • 520 citations
Molecular cloning and characterization of human endothelial nitric oxide synthase
1992 • 494 citations
Cellular regulation of endothelial nitric oxide synthase
2001 • 468 citations
Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation.
1999 • 424 citations
A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese
1998 • 407 citations
Reduced Endothelial Nitric Oxide Synthase Expression and Production in Human Atherosclerosis
1998 • 386 citations
Endothelial Nitric Oxide Synthase Gene Polymorphism and Acute Myocardial Infarction
1998 • 361 citations
Evidence of Association of the ecNOS Gene Polymorphism with Plasma NO Metabolite Levels in Humans
2000 • 355 citations
Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats.
1998 • 350 citations
Tetrahydrobiopterin and Dysfunction of Endothelial Nitric Oxide Synthase in Coronary Arteries
1995 • 295 citations
Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction
1999 • 290 citations
Gene Structure, Polymorphism and Mapping of the Human Endothelial Nitric Oxide Synthase Gene
1994 • 230 citations
Origin of superoxide production by endothelial nitric oxide synthase
1998 • 194 citations
Nitric oxide synthase gene polymorphisms, blood pressure and aortic stiffness in normotensive and hypertensive subjects
1998 • 180 citations
Cloning and structural characterization of the human endothelial nitric‐oxide‐synthase gene
1994 • 157 citations
Endothelial Nitric Oxide Synthase Exon 7 Polymorphism, Ischemic Cerebrovascular Disease, and Carotid Atheroma
1998 • 150 citations
Lack of Evidence for Association Between the Endothelial Nitric Oxide Synthase Gene and Hypertension
1999 • 143 citations
Protein–protein interactions controlling nitric oxide synthases
2000 • 130 citations
Nitric Oxide in Endothelial Dysfunction and Vascular Remodeling: Clinical Correlates and Experimental Links
1999 • 110 citations
A Neuronal NO Synthase (NOS1) Gene Polymorphism Is Associated with Asthma
2000 • 89 citations
Endothelial Nitric Oxide Synthase as a Potential Susceptibility Gene in the Pathogenesis of Emphysema in α 1-Antitrypsin Deficiency
1999 • 71 citations
Basal nitric oxide production is impaired in offspring of patients with essential hypertension
1999 • 51 citations
Pathophysiology and clinical applications of nitric oxide
2000 • 27 citations
Basal nitric oxide production is impaired in offspring of patients with essential hypertension
1999 • 18 citations
Short report: HYPERGENE: a clinical and genetic database for genetic analysis of human hypertension.
1994 • 16 citations
Pathophysiology and Clinical Applications of Nitric Oxide
1999 • 12 citations
HYPERGENE
1994 • 10 citations
Vascular Nitric Oxide in Health and Disease
2000 • 7 citations