Lack of Evidence for Linkage of the Endothelial Cell Nitric Oxide Synthase Gene to Essential Hypertension

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension

1990 • 2,388 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Molecular basis of human hypertension: Role of angiotensinogen

1992 • 1,861 citations

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

1989 • 1,625 citations

Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.

1993 • 1,102 citations

Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.

1990 • 1,020 citations

Blood Pressure Control—Special Role of the Kidneys and Body Fluids

1991 • 942 citations

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

1993 • 881 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.

1992 • 822 citations

Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine

1991 • 813 citations

Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension.

1990 • 803 citations

Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage.

1992 • 740 citations

Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension.

1993 • 707 citations

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

1992 • 616 citations

Evidence of Impaired Endothelium-Dependent Coronary Vasodilatation in Patients with Angina Pectoris and Normal Coronary Angiograms

1993 • 567 citations

Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle

1993 • 552 citations

Vasodilation to acetylcholine in primary and secondary forms of human hypertension.

1993 • 550 citations

Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta.

1987 • 534 citations

L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats.

1991 • 450 citations

Impaired Endothelium-Dependent Vasodilation in Patients With Essential Hypertension

1995 • 430 citations

Selective attenuation of endothelium-mediated vasodilation in atherosclerotic human coronary arteries.

1988 • 422 citations

Role of endothelium in dilator responses of spontaneously hypertensive rat arteries.

1983 • 414 citations

A comparison of sib‐pair linkage tests for disease susceptibility loci

1985 • 407 citations

Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats.

1987 • 404 citations

Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.

1994 • 403 citations

Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility

1991 • 378 citations

The loss of endothelium-dependent vascular relaxation in hypertension.

1986 • 372 citations

Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal.

1992 • 343 citations

Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension.

1993 • 288 citations

Preserved Endothelium-Dependent Vasodilatation in Patients with Essential Hypertension

1994 • 287 citations

Inhibition of nitric oxide synthesis increases blood pressure in healthy humans

1993 • 278 citations

Effect of antihypertensive treatment on endothelium-dependent vascular relaxation in patients with essential hypertension

1993 • 246 citations

Gene Structure, Polymorphism and Mapping of the Human Endothelial Nitric Oxide Synthase Gene

1994 • 230 citations

Linkage analysis of "necessary" disease loci versus "susceptibility" loci.

1993 • 218 citations

Modulation of angiotensin II-induced vasoconstriction by endothelium-derived relaxing factor in the isolated microperfused rabbit afferent arteriole.

1991 • 211 citations

Role of nitric oxide synthesis in salt-sensitive hypertension in Dahl/Rapp rats.

1993 • 201 citations

Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension.

1987 • 196 citations

Immunocytochemical localization of distinct isoforms of nitric oxide synthase in the juxtaglomerular apparatus of normal rat kidney.

1994 • 185 citations

Endothelium-derived relaxing factor inhibits renin release

1988 • 165 citations

The information contained in multiple sibling pairs

1984 • 148 citations

Induction of nitric oxide synthase gene by interleukin in vascular smooth muscle cells.

1993 • 123 citations

Endothelium-dependent responses to platelets and serotonin in spontaneously hypertensive rats.

1986 • 100 citations

Similar frequencies of renin gene restriction fragment length polymorphisms in hypertensive and normotensive subjects.

1990 • 91 citations

Cardiovascular responses to long-term blockade of nitric oxide synthesis.

1993 • 86 citations

Release of Norepinephrine From Adrenergic Nerve Endings of Blood Vessels Is Modulated by Endothelium-Derived Relaxing Factor

1990 • 75 citations

Expression of Two Types of Nitric Oxide Synthase mRNA in Human Neuroblastoma Cell Lines

1994 • 67 citations

Tests for Association of Gene Frequencies at Several Loci in Random Mating Diploid Populations

1975 • 57 citations

A test statistic for the affected‐sib‐set method

1986 • 51 citations

Enhanced release of endothelium-derived relaxing factor in mineralocorticoid hypertension.

1992 • 45 citations