A Common Variant of the Endothelial Nitric Oxide Synthase (Glu ²⁹⁸ →Asp) Is a Major Risk Factor for Coronary Artery Disease in the UK

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis

1992 • 4,765 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

1986 • 2,422 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

1996 • 2,163 citations

ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM

1987 • 1,450 citations

Genetic Susceptibility to Death from Coronary Heart Disease in a Study of Twins

1994 • 1,261 citations

Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction

1994 • 1,240 citations

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

1993 • 881 citations

L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.

1992 • 822 citations

Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

1997 • 585 citations

A smoking–dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene

1996 • 571 citations

Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits.

1994 • 501 citations

Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults.

1996 • 413 citations

Nitric Oxide Reversibly Inhibits the Migration of Cultured Vascular Smooth Muscle Cells

1996 • 412 citations

Inhibition of low‐density lipoprotein oxidation by nitric oxide Potential role in atherogenesis

1993 • 411 citations

Endothelial Nitric Oxide Synthase Gene Polymorphism and Acute Myocardial Infarction

1998 • 361 citations

The Endothelial Nitric-oxide Synthase-Caveolin Regulatory Cycle

1998 • 357 citations

The Structure of Nitric Oxide Synthase Oxygenase Domain and Inhibitor Complexes

1997 • 344 citations

Long-term inhibition of NO synthesis promotes atherosclerosis in the hypercholesterolemic rabbit thoracic aorta. PGH2 does not contribute to impaired endothelium-dependent relaxation.

1994 • 255 citations

A novel point mutation in the tyrosine kinase domain of the RET proto-oncogene in sporadic medullary thyroid carcinoma and in a family with FMTC.

1995 • 253 citations

Lack of Evidence for Linkage of the Endothelial Cell Nitric Oxide Synthase Gene to Essential Hypertension

1995 • 160 citations

Inhibition of low-density lipoprotein oxidation by nitric oxide

1993 • 119 citations

Nitric oxide synthases: biochemical and molecular regulation

1995 • 101 citations

Genetic analysis of atherosclerosis: a research paradigm for the common chronic diseases

1996 • 36 citations

Lack of linkage between the endothelial nitric oxide synthase gene and hypertension.

1996 • 36 citations

A Common Variant in Exon 7 of the Endothelial Constitutive Nitric Oxide Synthase Gene: Identification by Single Strand Conformation Polymorphism Analysis

1995 • 29 citations

Effects of Thrombolytic Therapy on Left Ventricular Function and the Importance of Long-Term Patency of the Infarct-Related Artery

1995 • 10 citations

Deleted Work

1955 • 0 citations