beta-Thalassemia in American Blacks: novel mutations in the "TATA" box and an acceptor splice site.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

A system for shotgun DNA sequencing

1981 • 2,710 citations

[68] Transcription maps of polyoma virus-specific RNA: Analysis by two-dimensional nuclease S1 gel mapping

1980 • 1,430 citations

Transcriptional Control Signals of a Eukaryotic Protein-Coding Gene

1982 • 1,406 citations

The structure and evolution of the human β-globin gene family

1980 • 1,398 citations

Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.

1977 • 1,372 citations

Mapping of RNA by a modification of the Berk-Sharp procedure: the 5′ termini of 15 S β-globin mRNA precursor and mature 10 S β-globin mRNA have identical map coordinates

1979 • 1,286 citations

Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster

1982 • 937 citations

Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.

1978 • 804 citations

Specific transcription and RNA splicing defects in five cloned β-thalassaemia genes

1983 • 627 citations

Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit β-globin gene in mouse 3T6 cells

1983 • 596 citations

Amplification and characterization of a β-globin gene synthesized in vitro

1976 • 495 citations

DNA sequence variants in the Gγ-, Aγ-, δ- and β-globin genes of man

1979 • 464 citations

Nonrandom association of polymorphic restriction sites in the β-globin gene cluster

1982 • 408 citations

A single-base change at a splice site in a β0-thalassemic gene causes abnormal RNA splicing

1982 • 372 citations

Abnormal RNA processing due to the exon mutation of βE-globin gene

1982 • 309 citations

[58] DNA sequence analysis by primed synthesis

1980 • 286 citations

β+ Thalassemia: Aberrant splicing results from a single point mutation in an intron

1981 • 235 citations

Origin of the beta S-globin gene in blacks: the contribution of recurrent mutation or gene conversion or both.

1984 • 221 citations

Polymorphism of DNA Sequence in the β-Globin Gene Region

1980 • 213 citations

Improved Detection of the Sickle Mutation by DNA Analysis

1982 • 171 citations

Etiology of Growth Hormone Deficiency in Little, Ames, and Snell Dwarf Mice^*

1983 • 155 citations

The genes for growth hormone and chorionic somatomammotropin are on the long arm of human chromosome 17 in region q21→qter

1981 • 138 citations

Restriction endonuclease mapping of the human γ globin gene loci

1979 • 129 citations

ATA box transcription mutation inβ-thalassemia

1983 • 109 citations

beta-Thalassemia in a Kurdish Jew. Single base changes in the T-A-T-A box.

1982 • 106 citations

Evidence for multiple origins of the beta E-globin gene in Southeast Asia.

1982 • 103 citations

Abnormally spliced messenger RNA in erythroid cells from patients with β+ thalassemia and monkey cells expressing a cloned β+-thalassemic gene

1982 • 91 citations

"Silent" nucleotide substitution in a beta+-thalassemia globin gene activates splice site in coding sequence RNA.

1983 • 90 citations

Abnormal splice in a mutant human beta-globin gene not at the site of a mutation.

1983 • 80 citations

Polymorphism and molecular pathology of the human beta-globin gene.

1983 • 73 citations

Frequencies of thalassemia in American blacks

1977 • 56 citations

Inactivation of an acceptor RNA splice site by a short deletion in beta-thalassemia.

1983 • 54 citations

Homozygous beta thalassemia in American Blacks: the problem of mild thalassemia.

1973 • 32 citations

Aplastic Crisis due to Extensive Bone Marrow Necrosis in Sickle Cell Disease

1982 • 21 citations