Improved Detection of the Sickle Mutation by DNA Analysis

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Nucleotide sequence of the rightward operator of phage lambda.

1975 • 2,068 citations

Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.

1978 • 804 citations

The nucleotide sequence of the human β-globin gene

1980 • 502 citations

Nonrandom association of polymorphic restriction sites in the β-globin gene cluster

1982 • 408 citations

ANTENATAL DIAGNOSIS OF SICKLE-CELL ANÆMIA BY D.N.A. ANALYSIS OF AMNIOTIC-FLUID CELLS

1978 • 380 citations

BILATERAL ZOSTER

1947 • 322 citations

Characterisation of deletions which affect the expression of fetal globin genes in man

1979 • 269 citations

Analysis of the β-δ-globin gene loci in normal and hb lepore DNA: Direct determination of gene linkage and intergene distance

1978 • 260 citations

Base substitution in an intervening sequence of a beta+-thalassemic human globin gene.

1981 • 236 citations

β+ Thalassemia: Aberrant splicing results from a single point mutation in an intron

1981 • 235 citations

Application of Endonuclease Mapping to the Analysis and Prenatal Diagnosis of Thalassemias Caused by Globin-Gene Deletion

1978 • 207 citations

DIRECT GENE ANALYSIS OF CHORIONIC VILLI: A POSSIBLE TECHNIQUE FOR FIRST-TRIMESTER ANTENATAL DIAGNOSIS OF HAEMOGLOBINOPATHIES

1981 • 189 citations

Prenatal Diagnosis of Hemoglobinopathies

1976 • 163 citations

Mutation in an intervening sequence splice junction in man.

1981 • 153 citations

Direct identification of sickle cell anemia by blot hybridization.

1981 • 148 citations

Prenatal Diagnosis of α-Thalassemia

1976 • 142 citations

Model for antenatal diagnosis of β-thalassaemia and other monogenic disorders by molecular analysis of linked DNA polymorphisms

1980 • 121 citations

ANTENATAL DIAGNOSIS OF SICKLE CELL ANAEMIA BY DIRECT ANALYSIS OF THE SICKLE MUTATION

1981 • 98 citations

PRENATAL DIAGNOSIS OF β-THALASSÆMIA AND SICKLE-CELL ANÆMIA

1977 • 91 citations

Adult Hemoglobin Synthesis by Reticulocytes from the Human Fetus at Midtrimester

1971 • 90 citations

Detection of the Sickle Gene in the Human Fetus

1972 • 89 citations

Prenatal diagnosis of sickle cell anemia by restriction and endonuclease analysis: HindIII polymorphisms in gamma-globin genes extend test applicability.

1980 • 79 citations

Prenatal diagnosis of beta-thalassemias by amniocentesis: linkage analysis using multiple polymorphic restriction endonuclease sites.

1980 • 68 citations

PRENATAL DIAGNOSIS OF HAEMOGLOBINOPATHIES: A STATUS REPORT

1981 • 44 citations