Synthesis of peptide fluoromethyl ketones and the inhibition of human cathepsin B

Methods in Enzymology , Vol

1966 • 26,261 citations

Esters of Methanesulfonic Acid as Irreversible Inhibitors of Acetylcholinesterase

1962 • 1,510 citations

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

1982 • 1,024 citations

N,N‐Dimethyl‐4‐pyridinamine, a Very Effective Acylation Catalyst

1969 • 521 citations

Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G Inhibition with peptide chloromethyl ketones

1977 • 224 citations

Peptidyl diazomethyl ketones are specific inactivators of thiol proteinases.

1981 • 208 citations

A GENERAL REACTION OF AMINO ACIDS. II

1928 • 168 citations

Current problems in mechanistic studies of serine and cysteine proteinases

1982 • 165 citations

A GENERAL REACTION OF AMINO ACIDS

1928 • 125 citations

Rapid inactivation of cathepsin L by Z-Phe-PheCHN2 and Z-Phe-AlaCHN2

1981 • 95 citations

Diazomethyl ketone substrate derivatives as active-site-directed inhibitors of thiol proteases. Papain

1977 • 56 citations

A comparison of the behavior of chymotrypsin and cathepsin B towards peptidyl diazomethyl ketones

1979 • 56 citations

An exploration of the primary specificity site of cathepsin B

1983 • 51 citations

Inactivation of cathepsin B1 by diazomethyl ketones

1977 • 34 citations

Papain-catalyzed reactions at subzero temperatures

1976 • 26 citations

The thiol proteinase inhibitors, Z-Phe-PheCHN2 and Z-Phe-AlaCHN2, inhibit lysosomal protein degradation in isolated rat hepatocytes

1983 • 18 citations

The interaction of α-diazoketones with hydroxylic solvents

1976 • 6 citations