The Retinoblastoma Protein-Binding Region of Simian Virus 40 Large T Antigen Alters Cell Cycle Regulation in Lenses of Transgenic Mice

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity

1962 • 6,970 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

Complete nucleotide sequence of SV40 DNA

1978 • 1,050 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation

1993 • 734 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

Lens Differentiation in Vertebrates

1981 • 638 citations

FVB/N: an inbred mouse strain preferable for transgenic analyses.

1991 • 600 citations

THE TUMOR SUPPRESSOR GENES

1993 • 509 citations

STRUCTURE AND FUNCTION OF SIMIAN VIRUS 40 LARGE TUMOR ANTIGEN

1992 • 506 citations

Limits of Neurogenesis in Primates

1985 • 486 citations

Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein

1991 • 464 citations

Hypoxanthine-guanine phosphoribosyltransferase genes of mouse and Chinese hamster: construction and sequence analysis of cDNA recombinants

1982 • 295 citations

Transgenic Models of Tumor Development

1991 • 289 citations

In vitro mutagenesis of a putative DNA binding domain of SV40 large-T

1984 • 248 citations

Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins

1991 • 244 citations

Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice.

1985 • 242 citations

An N-Terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110 and a second cellular protein, p120

1989 • 235 citations

Oncogenesis of the Lens in Transgenic Mice

1987 • 202 citations

Regulation of the fibroblast cell cycle by serum

1976 • 191 citations

Transplantable mouse tumor line induced by injection of SV40‐transformed mouse kidney cells

1969 • 173 citations

A simple and repid method for detection of apoptosis in human cells

1992 • 163 citations

The release of growth arrest by microinjection of adenovirus E1A DNA.

1985 • 154 citations

Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice.

1992 • 153 citations

In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential

1991 • 150 citations

Lens-specific expression of the chloramphenicol acetyltransferase gene promoted by 5' flanking sequences of the murine alpha A-crystallin gene in explanted chicken lens epithelia.

1985 • 132 citations

Fragments of the simian virus 40 transforming gene facilitate transformation of rat embryo cells.

1982 • 130 citations

Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiation

1993 • 126 citations

Retinoblastoma protein and the cell cycle

1993 • 91 citations

Integration of cell cycle control with transcriptional regulation by the retinoblastoma protein

1993 • 80 citations

The cell cycle then and now

1992 • 69 citations

Binding of p53 and p105-RB is not sufficient for oncogenic transformation by a hybrid polyomavirus-simian virus 40 large T antigen

1990 • 46 citations

Perturbed development of the mouse lens by polyomavirus large T antigen does not lead to tumor formation.

1989 • 39 citations

Tumor suppressor genes in the cell cycle

1992 • 34 citations

Structural comparisons of wild-type and nuclear transport-defective simian virus 40 large tumor antigens

1984 • 31 citations

Viral T-Antigen Interactions With Cellular Proto-oncogene and Anti-oncogene Products

1990 • 16 citations

Epitope mapping and conformational analysis of SV40 T-antigen deletion mutants

1992 • 7 citations

Solubilization of SV40 Plasma‐Membrane‐Associated Large Tumor Antigen Using Single‐Phase Concentrations of 1‐Butanol

1989 • 7 citations