The Pentacovalent Phosphorus Intermediate of a Phosphoryl Transfer Reaction

The Nature of the Chemical Bond

1939 • 13,296 citations

[16] SHELXL: High-resolution refinement

1997 • 2,469 citations

Stereochemical quality of protein structure coordinates

1992 • 1,503 citations

The Catalytic Pathway of Cytochrome P450cam at Atomic Resolution

2000 • 1,297 citations

Enzyme-Catalyzed Phosphoryl Transfer Reactions

1980 • 1,120 citations

The Depth of Chemical Time and the Power of Enzymes as Catalysts

2001 • 884 citations

Binding Energy, Specificity, and Enzymic Catalysis: The Circe Effect

1975 • 844 citations

Pseudo-rotation in the hydrolysis of phosphate esters

1968 • 763 citations

Electrostatic Origin of the Catalytic Power of Enzymes and the Role of Preorganized Active Sites

1998 • 586 citations

The Low Barrier Hydrogen Bond in Enzymatic Catalysis

1998 • 552 citations

Enzyme catalysis: not different, just better

1991 • 537 citations

Chemical Basis for Enzyme Catalysis

2000 • 282 citations

Ground State and Transition State Contributions to the Rates of Intramolecular and Enzymatic Reactions

1998 • 276 citations

Observation of Covalent Intermediates in an Enzyme Mechanism at Atomic Resolution

2001 • 269 citations

A View at the Millennium: the Efficiency of Enzymatic Catalysis

2002 • 269 citations

Mechanisms of signaling and related enzymes

1997 • 243 citations

Mechanisms of signaling and related enzymes

1997 • 223 citations

[2] Rapid quench kinetic analysis of polymerases, adenosinetriphosphatases, and enzyme intermediates

1995 • 184 citations

Reaction mechanism and structure of the active site of proline racemase

1975 • 117 citations

Dissecting long-range transcriptional mechanisms by chromatin immunoprecipitation

2002 • 116 citations

Caught in the Act: The Structure of Phosphorylated β-Phosphoglucomutase from Lactococcus lactis^,

2002 • 111 citations

Crystal Structures of Reaction Intermediates ofl-2-Haloacid Dehalogenase and Implications for the Reaction Mechanism

1998 • 103 citations

The crystal structure of muscle phosphoglucomutase refined at 2.7-angstrom resolution.

1992 • 88 citations

Purification and characterization of two phosphoglucomutases from Lactococcus lactis subsp. lactis and their regulation in maltose- and glucose-utilizing cells

1994 • 87 citations

Crystal Structure of PMM/PGM

2002 • 82 citations

Crystal Structures of Intermediates in the Dehalogenation of Haloalkanoates by l-2-Haloacid Dehalogenase

1999 • 79 citations

Preorganization and protein dynamics in enzyme catalysis

2002 • 70 citations

Atomic motion in enzymatic reaction coordinates

2001 • 64 citations

[13] Isotope effects: Determination of enzyme transition state structure

1995 • 59 citations

Product formation and phosphoglucomutase activities in Lactococcus lactis: cloning and characterization of a novel phosphoglucomutase gene

1997 • 57 citations

Covalent intermediate trapped in 2-keto-3-deoxy-6- phosphogluconate (KDPG) aldolase structure at 1.95-Å resolution

2001 • 52 citations

Kinetic Mechanism and pH Dependence of the Kinetic Parameters of Pseudomonas aeruginosa Phosphomannomutase/Phosphoglucomutase

2001 • 52 citations

Observation of unstable species in enzyme-catalyzed transformations using protein crystallography

2000 • 48 citations

Snapshot of a phosphorylated substrate intermediate by kinetic crystallography

1998 • 41 citations

Reactivity of Intermediates in Benzoylformate Decarboxylase: Avoiding the Path to Destruction

2002 • 26 citations

Transition state variation in enzymatic reactions

2001 • 26 citations

Crystal structure analysis of the exocytosis-sensitive phosphoprotein, pp63/parafusin (phosphoglucomutase), from Paramecium reveals significant conformational variability 1 1Edited by D. Rees

2002 • 25 citations

Oxyphosphorane and monomeric metaphosphate ion intermediates in phosphoryl transfer from 2,4-dinitrophenyl phosphate in aprotic and protic solvents

1979 • 21 citations

Synthesis, Kinetics, and Structural Studies of a Photolabile Caged Isocitrate: A Catalytic Trigger for Isocitrate Dehydrogenase

1996 • 21 citations

The trapping of hydroxyphosphoranes

1976 • 16 citations

Toward a Stable Hydroxyphosphorane

2001 • 12 citations

Rapid Mix-Quench MALDI-TOF Mass Spectrometry for Analysis of Enzymatic Systems

2002 • 7 citations

[7] Intermediates and energetics in pyruvate phosphate dikinase

1999 • 5 citations

A Survey of Covalent, Ionic, and Radical Intermediates in Enzyme-Catalyzed Reactions

2002 • 3 citations