Reactivity of Intermediates in Benzoylformate Decarboxylase: Avoiding the Path to Destruction

Thiamin diphosphate: a mechanistic update on enzymic and nonenzymic catalysis of decarboxylation

1987 • 251 citations

Tris(benzocyclobutadieno)benzene, the triangular [4]phenylene with a completely bond-fixed cyclohexatriene ring: cobalt-catalyzed synthesis from hexaethynylbenzene and thermal ring opening to 1,2:5,6:9,10-tribenzo-3,4,7,8,11,12-hexadehydro[12]annulene

1986 • 208 citations

The Crystal Structure of Benzoylformate Decarboxylase at 1.6 Å Resolution: Diversity of Catalytic Residues in Thiamin Diphosphate-Dependent Enzymes^,

1998 • 173 citations

Catalytic power of pyruvate decarboxylase. Rate-limiting events and microscopic rate constants from primary carbon and secondary hydrogen isotope effects

1991 • 78 citations

Exploring the Limits of Efficiency of Proton-Transfer Catalysis in Models and Enzymes

2000 • 59 citations

Spectroscopic Detection of Transient Thiamin Diphosphate-Bound Intermediates on Benzoylformate Decarboxylase

2000 • 46 citations

Kinetics of C(2α)-Proton Abstraction from 2-Benzylthiazolium Salts Leading to Enamines Relevant to Catalysis by Thiamin-Dependent Enzymes

1997 • 42 citations

Diverting Thiamin from Catalysis to Destruction. Mechanism of Fragmentation of N(1')-Methyl-2-(1-hydroxybenzyl)thiamin

1995 • 33 citations

Destruction of Vitamin B1 by Benzaldehyde. Reactivity of Intermediates in the Fragmentation of N1‘-Benzyl-2-(1-hydroxybenzyl)thiamin

2000 • 32 citations

Differential reactivity in the processing of [p-(halomethyl)benzoyl]formates by benzoylformate decarboxylase, a thiamine pyrophosphate dependent enzyme

1988 • 31 citations

Inhibition of benzoylformate decarboxylase by [p-(bromomethyl)benzoyl]formate. Enzyme-catalyzed modification of thiamine pyrophosphate by halide elimination and tautomerization

1986 • 28 citations

Decomposition of 2-(1-Hydroxybenzyl)thiamin in Neutral Aqueous Solutions: Benzaldehyde and Thiamin Are Not the Products

1993 • 27 citations

Conformation of complexes of thiamin pyrophosphate with divalent cations as studied by nuclear magnetic resonance spectroscopy.

1975 • 24 citations

THE STRUCTURE OF ASPIDOSPERMINE

1957 • 13 citations

Involvement of arginine residues in the activation of calmodulin-dependent 3',5'-cyclic-nucleotide phosphodiesterase

1988 • 5 citations