Enzyme catalysis: not different, just better

The P-loop — a common motif in ATP- and GTP-binding proteins

1990 • 2,029 citations

Einfluss der Configuration auf die Wirkung der Enzyme

1894 • 1,695 citations

Prediction of the occurrence of the ADP-binding βαβ-fold in proteins, using an amino acid sequence fingerprint

1986 • 1,172 citations

Molecular Architecture and Biological Reactions

1946 • 835 citations

Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5Å resolution: using amino acid sequence data

1975 • 638 citations

Biological properties of human c-Ha-ras1 genes mutated at codon 12

1984 • 586 citations

The role of the α-helix dipole in protein function and structure

1985 • 517 citations

Glucose-induced conformational change in yeast hexokinase.

1978 • 305 citations

Phosphate‐binding sequences in nucleotide‐binding proteins

1985 • 295 citations

Anatomy of a Conformational Change: Hinged "Lid" Motion of the Triosephosphate Isomerase Loop

1990 • 282 citations

Stabilization of a reaction intermediate as a catalytic device: definition of the functional role of the flexible loop in triosephosphate isomerase

1990 • 271 citations

Structure-Function Relationships in Lactate Dehydrogenase

1973 • 252 citations

Free-energy profile for the reaction catalyzed by triosephosphate isomerase

1976 • 241 citations

Stabilization of protein structure by interaction of α-helix dipole with a charged side chain

1988 • 229 citations

The Mechanism of the Triosephosphate Isomerase Reaction

1959 • 218 citations

On the three-dimensional structure and catalytic mechanism of triose phosphate isomerase

1981 • 216 citations

Crystallographic analysis of the complex between triosephosphate isomerase and 2-phosphoglycolate at 2.5-.ANG. resolution: implications for catalysis

1990 • 216 citations

Stereoelectronic Control in Enolization-Ketonization Reactions¹

1956 • 209 citations

Acid-base catalysis of the elimination and isomerization reactions of triose phosphates

1984 • 202 citations

Transition-state stabilization in the mechanism of tyrosyl-tRNA synthetase revealed by protein engineering.

1985 • 179 citations

Nitrogen-15 NMR spectroscopy of hydrogen-bonding interactions in the active site of serine proteases: evidence for a moving histidine mechanism

1986 • 179 citations

Site-directed mutagenesis reveals role of mobile arginine residue in lactate dehydrogenase catalysis

1986 • 179 citations

Substrate binding closes the cleft between the domains of yeast phosphoglycerate kinase.

1979 • 173 citations

On the importance of orientation in general base catalysis by carboxylate

1981 • 172 citations

Triosephosphate isomerase: removal of a putatively electrophilic histidine residue results in a subtle change in catalytic mechanism

1988 • 126 citations

Mutations in the nucleotide binding loop of adenylate kinase of Escherichia coli

1988 • 114 citations

Direct observation of substrate distortion by triosephosphate isomerase using Fourier transform infrared spectroscopy

1980 • 111 citations

Structure and activity of phosphoglycerate mutase

1981 • 107 citations

The pKa values of two histidine residues in human haemoglobin, the Bohr effect, and the dipole moments of α-helices

1985 • 105 citations

Reaction energetics of a mutant triose phosphate isomerase in which the active-site glutamate has been changed to aspartate

1986 • 103 citations

Energetics of triosephosphate isomerase: the appearance of solvent tritium in substrate dihydroxyacetone phosphate and in product

1976 • 49 citations

NMR study of the phosphoryl binding loop in purine nucleotide proteins: evidence for strong hydrogen bonding in human N-ras p21

1990 • 49 citations

Crystallography and Site-directed Mutagenesis of Yeast Triosephosphate Isomerase: What Can We Learn about Catalysis from a "Simple" Enzyme?

1987 • 44 citations

How can a catalytic lesion be offset? The energetics of two pseudorevertant triosephosphate isomerases

1990 • 44 citations

THE STRUCTURE OF CARBOXYPEPTIDASE A, IV. PRELIMINARY RESULTS AT 2.8 Å RESOLUTION, AND A SUBSTRATE COMPLEX AT 6 Å RESOLUTION

1967 • 33 citations

Stereoelectronic effects and the active site of the serine proteases

1988 • 33 citations

Critical ionization states in the reaction catalyzed by triosephosphate isomerase

1978 • 33 citations

Stereoelectronic effects at carboxylate: a syn-oriented model for the histidine-aspartate couple in enzymes

1988 • 29 citations

The existence of an electrophilic component in the reaction catalysed by triose phosphate isomerase

1974 • 22 citations

Enzyme substrate and inhibitor interactions

1975 • 12 citations