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Factors controlling the rate of fatty acid β-oxidation in rat liver mitochondria

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Mitochondrial Carnitine Palmitoyltransferase I Isoform Switching in the Developing Rat Heart

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Fatty acid-binding protein and its relation to fatty acid oxidation

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Expression of a cDNA Isolated from Rat Brown Adipose Tissue and Heart Identifies the Product as the Muscle Isoform of Carnitine Palmitoyltransferase I (M-CPT I)

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Molecular Cloning of cDNA Encoding Rat Very Long-chain Acyl-CoA Synthetase

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1996 • 147 citations

Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: evidence for functionally separate pools of acyl-CoA

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Human liver long-chain 3-hydroxyacyl-coenzyme a dehydrogenase is a multifunctional membrane-bound beta-oxidation enzyme of mitochondria

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Carnitine palmitoyltransferase and carnitine octanoyltransferase activities in liver, kidney cortex, adipocyte, lactating mammary gland, skeletal muscle and heart

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Fatty Acids Rapidly Induce the Carnitine Palmitoyltransferase I Gene in the Pancreatic β-Cell Line INS-1

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Cloning and Functional Expression of a Novel Long-Chain Acyl-CoA Synthetase Expressed in Brain1

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Acyl‐CoA binding proteins: Multiplicity and function

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Quantitation of the effect of L-carnitine on the levels of acid-soluble short-chain acyl-CoA and CoASH in rat heart and liver mitochondria.

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The synthesis of hippurate from benzoate and glycine by rat liver mitochondria. Submitochondrial localization and kinetics

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Role of carnitine and carnitine palmitoyltransferase as integral components of the pathway for membrane phospholipid fatty acid turnover in intact human erythrocytes.

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Characterization of a New Member of the Fatty Acid-binding Protein Family That Binds All-trans-retinol

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Combined enzyme defect of mitochondrial fatty acid oxidation.

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Role of insulin in hepatic fatty acid partitioning: emerging concepts

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Rat heart expresses two forms of mitochondrial carnitine palmitoyltransferase I. The minor component is identical to the liver enzyme.

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Fat Metabolism During Exercise: A Review. Part I: Fatty Acid Mobilization and Muscle Metabolism

1998 • 123 citations

Fatty acid oxidation in rat brain is limited by the low activity of 3-ketoacyl-coenzyme A thiolase.

1987 • 122 citations

The regulation of the oxidation of fatty acids and other substrates in rat heart mitochondria by changes in the matrix volume induced by osmotic strength, valinomycin and Ca2+

1987 • 121 citations

The Carnitine Acyltransferases and Their Role in Modulating Acyl-CoA Pools

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Gestational, pathologic and biochemical differences between very long-chain acyl-CoA dehydrogenase deficiency and long-chain acyl-CoA dehydrogenase deficiency in the mouse

2001 • 118 citations

Troglitazone Inhibits Fatty Acid Oxidation and Esterification, and Gluconeogenesis in Isolated Hepatocytes from Starved Rats

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Top Down Metabolic Control Analysis

1996 • 117 citations

Purification and properties of a pig heart thiolase with broad chain length specificity and comparison of thiolases from pig heart and Escherichia coli.

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Fat Metabolism During Exercise: A Review - Part II: Regulation of Metabolism and the Effects of Training

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Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation: Inter-tissue and inter-species expression of CPT I and CPT II enzymes

1997 • 114 citations

Enoyl Coenzyme A Hydratase (Crotonase)

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Regulation of fatty acid oxidation in mammalian liver

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Very long‐chain acyl coenzyme A dehydrogenase deficiency presenting with exercise‐induced myoglobinuria

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Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency

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The role of intermediates in mitochondrial fatty acid oxidation

1975 • 109 citations

Variation of liver-type fatty acid binding protein content in the human hepatoma cell line HepG2 by peroxisome proliferators and antisense RNA affects the rate of fatty acid uptake

1999 • 108 citations

The Yeast Mitochondrial Carrier Leu5p and Its Human Homologue Graves' Disease Protein Are Required for Accumulation of Coenzyme A in the Matrix

2001 • 107 citations

The specificity of glycine-N-acylase and acylglycine excretion in the organicacidaemias

1974 • 107 citations

The malonyl-CoA–long-chain acyl-CoA axis in the maintenance of mammalian cell function

1999 • 107 citations

Flux control exerted by mitochondrial outer membrane carnitine palmitoyltransferase over β-oxidation, ketogenesis and tricarboxylic acid cycle activity in hepatocytes isolated from rats in different metabolic states

1996 • 105 citations

Quantitation of the efflux of acylcarnitines from rat heart, brain, and liver mitochondria.

1986 • 102 citations

Acyl-Coenzyme A Synthetase and Fatty Acid Oxidation in Rat Liver Peroxisomes

1978 • 102 citations

Myocardial triglyceride turnover during reperfusion of isolated rat hearts subjected to a transient period of global ischemia.

1992 • 101 citations

MCD Encodes Peroxisomal and Cytoplasmic Forms of Malonyl-CoA Decarboxylase and Is Mutated in Malonyl-CoA Decarboxylase Deficiency

1999 • 99 citations

Control of energy production in the heart: a new function for fatty acid binding protein

1985 • 99 citations

The stimulus-secretion coupling of glucose-induced insulin release: Fuel metabolism in islets deprived of exogenous nutrient

1983 • 99 citations

Ophthalmologic findings in long-chain 3-hydroxyacyl-Coa dehydrogenase deficiency caused by the G1528C mutation

1998 • 99 citations

Isoforms of Rat Liver Fatty Acid Binding Protein Differ in Structure and Affinity for Fatty Acids and Fatty Acyl CoAs

1997 • 97 citations

2-Bromopalmitoyl-CoA and 2-bromopalmitate: Promiscuous inhibitors of membrane-bound enzymes

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Electron transfer flavoprotein-ubiquinone oxidoreductase from pig liver: purification and molecular, redox, and catalytic properties

1985 • 95 citations

Acyl-CoA dehydrogenases, electron transfer flavoprotein and electron transfer flavoprotein dehydrogenase

1988 • 91 citations

Short-Chain Acyl-Coenzyme A Dehydrogenase Deficiency in Mice

1989 • 91 citations

Role of Carnitine Palmitoyltransferase I in the Control of Ketogenesis in Primary Cultures of Rat Astrocytes

1998 • 91 citations

A Novel mechanism for inhibition of β‐oxidation by methylenecyclopropylacetyl‐CoA, a metabolite of hypoglycin

1975 • 91 citations

Long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency

1999 • 90 citations

On the Mechanism of Long Chain Fatty Acid Transport in Cardiomyocytes as Facilitated by Cytoplasmic Fatty Acid-binding Protein

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Fat Metabolism During Exercise: A Review. Part III: Effects of Nutritional Interventions

1998 • 89 citations

Long-chain acyl-CoA dehydrogenase is a key enzyme in the mitochondrial β-oxidation of unsaturated fatty acids

2000 • 88 citations

Development and characterization of an animal model of carnitine deficiency

2001 • 88 citations

Characterization and binding properties of fatty acid-binding proteins from human, pig, and rat heart

1988 • 87 citations

The Metabolism of (-)-Octanoylcarnitine in Perfused Livers from Fed and Fasted Rats

1974 • 87 citations

Training-induced elevation in FABP_PMis associated with increased palmitate use in contracting muscle

1999 • 86 citations

The steady state concentrations of coenzyme A-SH and coenzyme A thioester, citrate, and isocitrate during tricarboxylate cycle oxidations in rabbit heart mitochondria.

1975 • 86 citations

Developmental changes in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression in rat liver, intestine and kidney

1993 • 85 citations

Separation, properties, and regulation of acyl coenzyme A dehydrogenases from bovine heart and liver

1982 • 85 citations

Modulation of fatty-acid-binding protein content of rat heart and skeletal muscle by endurance training and testosterone treatment

1992 • 85 citations

Short‐chain<scp>L</scp>‐3‐hydroxyacyl‐CoA dehydrogenase deficiency in muscle: A new cause for recurrent myoglobinuria and encephalopathy

1991 • 84 citations

Short-chain acyl–CoA dehydrogenase deficiency

1999 • 83 citations

Advances in Intravenous Lipid Emulsions

2000 • 83 citations

The intracellular and intramitochondrial distribution of malonyl-CoA decarboxylase and propionyl-CoA carboxylase in rat liver

1969 • 83 citations

14CO2 production is no adequate measure of [14C]fatty acid oxidation

1986 • 83 citations

Two Mitochondrial 3-Hydroxyacyl-CoA Dehydrogenases in Bovine Liver

1996 • 82 citations

Molecular analysis of carnitine palmitoyltransferase II deficiency with hepatocardiomuscular expression.

1996 • 82 citations

The metabolism of lipids in mouse pancreatic islets. The oxidation of fatty acids and ketone bodies

1975 • 81 citations

The synthesis and characterisation of 2-methylacetoacetyl coenzyme A and its use in the identification of the site of the defect in 2-methylacetoacetic and 2-methyl-3-hydroxybutyric aciduria

1983 • 81 citations

Mechanisms of the metabolic disturbances caused by hypoglycin and by pent-4-enoic acid. In vitro studies.

1978 • 80 citations

Substrate Channeling of NADH and Binding of Dehydrogenases to Complex I

1989 • 80 citations

Mitochondrial Short-Chain L-3-Hydroxyacl-Coenzyme A Dehydrogenase Deficiency: A New Defect of Fatty Acid Oxidation

1996 • 80 citations

Oleic acid uptake and binding by rat adipocytes define dual pathways for cellular fatty acid uptake

2001 • 79 citations

Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency

1999 • 79 citations

Rat very-long-chain acyl-CoA dehydrogenase, a novel mitochondrial acyl-CoA dehydrogenase gene product, is a rate-limiting enzyme in long-chain fatty acid beta-oxidation system. cDNA and deduced amino acid sequence and distinct specificities of the cDNA-expressed protein.

1994 • 79 citations

Purification and Characterization of Long-Chain Acyl-CoA Hydrolase from Rat Liver Mitochondria

1979 • 78 citations

The mitochondrial trifunctional protein: centre of a β-oxidation metabolon?

2000 • 78 citations

Long Chain Enoyl Coenzyme A Hydratase from Pig Heart

1974 • 77 citations

Rhabdomyolysis and acute encephalopathy in late onset medium chain acyl-CoA dehydrogenase deficiency.

1995 • 76 citations

Binding of Cytochrome P450 Monooxygenase and Lipoxygenase Pathway Products by Heart Fatty Acid-Binding Protein

2001 • 76 citations

Malonyl coenzyme a decarboxylase deficiency

1983 • 74 citations

Overexpression of UCP-3 in Skeletal Muscle of Mice Results in Increased Expression of Mitochondrial Thioesterase mRNA

2001 • 73 citations

Regulation of fatty acid transporters in mammalian cells

2000 • 73 citations

Glucose stimulation of insulin secretion in islets of fed and starved rats and its dependence on lipid metabolism

1986 • 72 citations

Estrogen increases the permeability of the cultured human cervical epithelium by modulating cell deformability

1998 • 72 citations

Preferential binding of growth inhibitory prostaglandins by the target protein of a carcinogen.

1990 • 72 citations

Experimental application of top-down control analysis to metabolic systems

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Metabolic regulation: a human perspective

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On the rate-determining step of fatty acid oxidation in heart. Inhibition of fatty acid oxidation by 4-pentenoic acid.

1978 • 70 citations

Very Long Chain and Long Chain Acyl-CoA Thioesterases in Rat Liver Mitochondria

1995 • 69 citations

Purification and properties of malonyl-CoA decarboxylase from rat liver mitochondria and its immunological comparison with the enzymes from rat brain, heart, and mammary gland

1978 • 69 citations

Metabolic consequences of methylenecyclopropylglycine poisoning in rats

1991 • 69 citations

Regulation of palmitoylcarnitine oxidation in isolated rat liver mitochondria. Role of the redox state of NAD(H)

1986 • 69 citations

Channelling in Intermediary Metabolism

1996 • 69 citations

Purification and Characteristics of a Butyryl Coenzyme A Synthetase from Bovine Heart Mitochondria

1965 • 68 citations

Reactions of electron-transfer flavoprotein and electron-transfer flavoprotein: ubiquinone oxidoreductase

1987 • 68 citations

Characterization of rat liver malonyl-CoA decarboxylase and the study of its role in regulating fatty acid metabolism

2000 • 67 citations

Binding of malonyl-CoA to isolated mitochondria. Evidence for high- and low-affinity sites in liver and heart and relationship to inhibition of carnitine palmitoyltransferase activity

1984 • 67 citations

Molecular cloning and characterization of a mitochondrial peroxisome proliferator-induced acyl-CoA thioesterase from rat liver

1998 • 67 citations

Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Effects of the free acids and their carnitine esters on coenzyme A-dependent oxidations in rat liver mitochondria

1973 • 67 citations

Cloning of human very-long-chain acyl-coenzyme A dehydrogenase and molecular characterization of its deficiency in two patients.

1995 • 67 citations

Medium Chain 3-Ketoacyl-Coenzyme A Thiolase Deficiency: A New Disorder of Mitochondrial Fatty Acid β-Oxidation

1997 • 66 citations

Self-association of the cardiac fatty acid binding protein. Influence on membrane-bound, fatty acid dependent enzymes

1983 • 66 citations

Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Effects of their coenzyme A esters on enzymes of fatty acid oxidation

1973 • 66 citations

Microsomal fatty acyl-CoA transacylation and hydrolysis: fatty acyl-CoA species dependent modulation by liver fatty acyl-CoA binding proteins11This work was supported in part by a grant from the USPHS National Institutes of Health, DK41402.

2000 • 65 citations

[65] Pyruvate dehydrogenase complex from bovine kidney and heart

1982 • 65 citations

Enrichment of carnitine palmitoyltransferases I and II in the contact sites of rat liver mitochondria

1998 • 65 citations

DEFECTIVE ENERGY METABOLISM OF THE HEART IN DIABETES

1985 • 64 citations

Defects in activation and transport of fatty acids

1999 • 64 citations

Acute Reversal of Experimental Diabetic Ketoacidosis in the Rat with (+)-Decanoylcarnitine

1973 • 63 citations

Expression of human liver fatty acid-binding protein in Escherichia coli and comparative analysis of its binding characteristics with muscle fatty acid-binding protein

1994 • 63 citations

Improved detection of long‐chain fatty acid oxidation defects in intact cells using [9,10‐3H]oleic acid

1997 • 61 citations

Coenzyme A sequestration in rat hearts oxidizing ketone bodies.

1992 • 61 citations

Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase

1999 • 60 citations

The Effects of Temperature and Some Inhibitors an the Carnitine Exchange System of Heart Mitochondria

1976 • 60 citations

Inhibitors of fatty acid oxidation

1987 • 60 citations

Reaction of electron-transfer flavoprotein ubiquinone oxidoreductase with the mitochondrial respiratory chain

1987 • 59 citations

Intramitochondrial regulation of fatty acid β-oxidation occurs between flavoprotein and ubiquinone A role for changes in the matrix volume

1986 • 59 citations

Interaction of acyl coenzyme A substrates and analogs with pig kidney medium-chain acyl-CoA dehydrogenase

1987 • 58 citations

Evidence for the Involvement of Carnitine‐Dependent Long‐Chain Acyltransferases in Neuronal Triglyceride and Phospholipid Fatty Acid Turnover

1994 • 58 citations

Inhibition of fatty acid oxidation by 2-bromooctanoate. Evidence for the enzymatic formation of 2-bromo-3-ketooctanoyl coenzyme A and the inhibition of 3-ketothiolase.

1979 • 58 citations

A Single Amino Acid Change (Substitution of Glutamate 3 with Alanine) in the N-terminal Region of Rat Liver Carnitine Palmitoyltransferase I Abolishes Malonyl-CoA Inhibition and High Affinity Binding

1999 • 57 citations

Nutrient metabolism in islet cells

1984 • 56 citations

Roles of the N- and C-terminal domains of carnitine palmitoyltransferase I isoforms in malonyl-CoA sensitivity of the enzymes: insights from expression of chimaeric proteins and mutation of conserved histidine residues

1998 • 56 citations

Participation of endogenous fatty acids in the secretory activity of the pancreatic B-cell

1985 • 56 citations

Fuel selection in intestinal cells

1995 • 55 citations

Stimulation of Islet Protein Kinase C Translocation by Palmitate Requires Metabolism of the Fatty Acid

1997 • 55 citations

The mechanism of inhibition of β-oxidation by aspirin metabolites in skin fibroblasts from Reye’s syndrome patients and controls

1999 • 55 citations

Alpha-Keto acid dehydrogenase complexes, V. Macromolecular organization of pyruvate and alpha-ketoglutarate dehydrogenase complexes isolated from beef kidney mitochondria.

1966 • 54 citations

Glutaric acidemia type II. Heterogeneity in beta-oxidation flux, polypeptide synthesis, and complementary DNA mutations in the alpha subunit of electron transfer flavoprotein in eight patients.

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Multiple Promoters in Rat Acyl-CoA Synthetase Gene Mediate Differential Expression of Multiple Transcripts with 5′-End Heterogeneity

1995 • 53 citations

The Molecular Basis of Malonyl-CoA Decarboxylase Deficiency

1999 • 52 citations

Functional Studies of Yeast-Expressed Human Heart Muscle Carnitine Palmitoyltransferase I

1997 • 52 citations

Preliminary evidence for the existence of specific functional assemblies between enzymes of the beta-oxidation pathway and the respiratory chain.

2000 • 52 citations

Effects of intestinal fatty acid-binding protein overexpression on fatty acid metabolism in Caco-2 cells

2000 • 52 citations

Regulation of Fatty Acid Oxidation by Acetyl-CoA Generated from Glucose Utilization in Isolated Myocytes

1996 • 51 citations

5 Malonyl-CoA???Regulator of Fatty Acid Oxidation in Muscle During Exercise

1998 • 49 citations

Monitoring of changes in hepatic fatty acid and glycerolipid metabolism during the starved-to-fed transition in vivo. Studies on awake, unrestrained rats

1993 • 48 citations

Fatal Hepatic Short-Chain l-3-Hydroxyacyl-Coenzyme a Dehydrogenase Deficiency: Clinical, Biochemical, and Pathological Studies on Three Subjects with This Recently Identified Disorder of Mitochondrial β-Oxidation

1999 • 48 citations

Influence of malonyl-CoA and palmitate concentration on rate of palmitate oxidation in rat muscle

1998 • 48 citations

Utilisation of triacylglycerol and non-esterified fatty acid by the working rat heart: myocardial lipid substrate preference

2001 • 47 citations

Molecular cloning of rat mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase and detection of the corresponding mRNA and of those encoding the remaining enzymes comprising the ketogenic 3-hydroxy-3-methylglutaryl-CoA cycle in central nervous system of suckling rat

1998 • 47 citations

Insulin stimulation of glucose uptake fails to decrease palmitate oxidation in muscle if AMPK is activated

2000 • 47 citations

Malonic aciduria and cardiomyopathy

1993 • 47 citations

2,6-Dimethylheptanoyl-CoA is a specific substrate for long-chain acyl-CoA dehydrogenase (LCAD): evidence for a major role of LCAD in branched-chain fatty acid oxidation

1998 • 47 citations

Malonyl coenzyme A decarboxylase deficiency. Clinical and biochemical findings in a second child with a more severe enzyme defect

1986 • 47 citations

Reversal by CoA of palmityl-CoA inhibition of long chain ACYL-CoaA synthetase activity

1973 • 47 citations

Inhibition of general acyl CoA dehydrogenase by electron transfer flavoprotein semiquinone

1981 • 47 citations

Regulation of Thiolases from Pig Heart. Control of Fatty Acid Oxidation in Heart

1980 • 47 citations

Developmental changes in carnitine palmitoyltransferases I and II gene expression in intestine and liver of suckling rats

1995 • 46 citations

Handbook of Clinical Neurology, Volume 14

1974 • 46 citations

Submitochondrial and subcellular distributions of the carnitine‐acylcarnitine carrier

1999 • 46 citations

Effects of the fatty acid blocking agents, oxfenicine and 4-bromocrotonic acid, on performance in aerobic and ischemic myocardium*

1987 • 46 citations

Expression and Characterization of Two Pathogenic Mutations in Human Electron Transfer Flavoprotein

1997 • 46 citations

More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling

1994 • 46 citations

Malonyl-CoA metabolism in cardiac myocytes

2000 • 45 citations

Interrelations between hepatic fatty acid oxidation and gluconeogenesis: a possible regulatory role of carnitine palmityltransferase.

1967 • 45 citations

Cloning and expression of cDNA for a newly identified isozyme of bovine liver 3-hydroxyacyl-CoA dehydrogenase and its import into mitochondria

1997 • 45 citations

4-Bromocrotonic acid, an effective inhibitor of fatty acid oxidation and ketone body degradation in rat heart mitochondria. On the rate-determining step of beta-oxidation and ketone body degradation in heart.

1982 • 45 citations

Intermediates in fatty acid oxidation

1973 • 44 citations

Identification of Positive and Negative Determinants of Malonyl-CoA Sensitivity and Carnitine Affinity within the Amino Termini of Rat Liver- and Muscle-type Carnitine Palmitoyltransferase I

2000 • 44 citations

Differential diagnosis of hydroxydicarboxylic aciduria based on release of³H₂O from [9,10‐³H]myristic and [9,10‐³H]palmitic acids by intact cultured fibroblasts

1992 • 44 citations

Skeletal muscle mitochondrial β-oxidation. A study of the products of oxidation of [U-14C]hexadecanoate by h.p.l.c. using continuous on-line radiochemical detection

1988 • 44 citations

The flux control coefficient of carnitine palmitoyltransferase I on palmitate β-oxidation in rat hepatocyte cultures

1997 • 43 citations

Intermediates of peroxisomal β-oxidation. A study of the fatty acyl-CoA esters which accumulate during peroxisomal β-oxidation of [U-14C]hexadecanoate

1990 • 43 citations

Purification and properties of carnitine acetyltransferase from human liver

1990 • 42 citations

Use of Six Chimeric Proteins to Investigate the Role of Intramolecular Interactions in Determining the Kinetics of Carnitine Palmitoyltransferase I Isoforms

2000 • 42 citations

Malonyl coenzyme A decarboxylase deficiency.

1993 • 42 citations

Functional Analysis of Mutant Human Carnitine Acylcarnitine Translocases in Yeast

2001 • 42 citations

Malonyl-CoA-independent Acute Control of Hepatic Carnitine Palmitoyltransferase I Activity

1998 • 42 citations

Kinetic advantage of the interaction between the fatty acid β-oxidation enzymes and the complexes of the respiratory chain

1991 • 41 citations

Analysis of fatty acid oxidation intermediates in cultured fibroblasts to detect mitochondrial oxidation disorders

1994 • 41 citations

Inactivation of pig heart thiolase by 3-butynoyl coenzyme A, 3-pentynoyl coenzyme A, and 4-bromocrotonyl coenzyme A

1973 • 41 citations

Cloning and expression of rat pancreatic β-cell malonyl-CoA decarboxylase

1999 • 41 citations

Effects of adrenaline on triacylglycerol synthesis and turnover in ventricular myocytes from adult rats

1997 • 40 citations

Travels with carnitine palmitoyltransferase I: from liver to germ cell with stops in between

2001 • 40 citations

Accumulation of Carnitine Esters of beta-Oxidation Intermediates during Palmitate Oxidation by Rat-Liver Mitochondria

1978 • 40 citations

Incomplete fatty acid oxidation. The production and epimerization of 3-hydroxy fatty acids.

1992 • 40 citations

Role of fatty acid-binding protein in cardiac fatty acid oxidation

1990 • 39 citations

Alterations in carnitine–acylcarnitine translocase activity and in phospholipid composition in heart mitochondria from hypothyroid rats

1997 • 39 citations

Evidence for an impaired long‐chain fatty acid oxidation and ketogenesis in Fao hepatoma cells

1992 • 39 citations

Self-aggregation, a new property of cardiac fatty acid-binding protein. Predictable influence on energy production in the heart.

1983 • 38 citations

Inhibition of long-chain fatty acid activation by α-bromopalmitate and phytanate

1971 • 38 citations

Fatty acid-binding protein, a potential regulator of energy production in the heart. Investigation of mechanisms by electron spin resonance.

1988 • 38 citations

Assay of l-3-hydroxyacyl-coenzyme A dehydrogenase with substrates of different chain lengths

1989 • 38 citations

Stimulation of carnitine acylcarnitine translocase activity in heart mitochondria from hyperthyroid rats

1996 • 38 citations

An Explanation for Ketogenesis by the Intestine of the Suckling Rat: The Presence of an Active Hydroxymethylglutaryl-Coenzyme A Pathway

1990 • 38 citations

Regulation of fatty acid β-oxidation in rat heart mitochondria

1991 • 38 citations

The role of changes in the sensitivity of hepatic mitochondrial overt carnitine palmitoyltransferase in determining the onset of the ketosis of starvation in the rat

1996 • 38 citations

Comparison of the active sites of the purified carnitine acyltransferases from peroxisomes and mitochondria by using a reaction-intermediate analogue

1993 • 37 citations

Succinic Thiokinase

1967 • 36 citations

Very‐long‐chain acyl‐CoA dehydrogenase subunit assembles to the dimer form on mitochondrial inner membrane

1998 • 36 citations

Computer simulation of metabolism in palmitate-perfused rat heart. II. Behavior of complete model

1983 • 36 citations

Mild or absent clinical signs in twin sisters with short-chain acyl-CoA dehydrogenase deficiency

1998 • 36 citations

The involvement of carnitine intermediates in peroxisomal fatty acid oxidation: A study with 2-bromofatty acids

1990 • 36 citations

Different metabolic adaptation of heart and skeletal muscles to moderate-intensity treadmill training in the rat

1999 • 36 citations

Clinical consequences of defects in peroxisomal β-oxidation

2001 • 36 citations

The effect of respiratory chain impairment of β-oxidation in rat heart mitochondria

1996 • 36 citations

Metallothionein-IIAPromoter Induction Alters Rat Intestinal Fatty Acid Binding Protein Expression, Fatty Acid Uptake, and Lipid Metabolism in Transfected L-Cells

1997 • 35 citations

Fatty Acid Oxidation in Peripheral Blood Cells: Characterization and Use for the Diagnosis of Defects of Fatty Acid Oxidation

1995 • 35 citations

The malonyl-CoA‒long-chain acyl-CoA axis in the maintenance of mammalian cell function

1999 • 35 citations

Structure and Function of Normal and Transformed Murine Acyl-CoA Binding Proteins

1998 • 35 citations

A top-down control analysis in isolated rat liver mitochondria: can the 3-hydroxy-3-methylglutaryl-CoA pathway be rate-controlling for ketogenesis?

1993 • 35 citations

Properties of Malonyl‐CoA Decarboxylase and its Relation with Malonyl‐CoA Incorporation into Fatty Acids by Rat Liver Mitochondria

1971 • 34 citations

Molecular Cloning and Characterization of MT-ACT48, a Novel Mitochondrial Acyl-CoA Thioesterase

1999 • 34 citations

Troglitazone inhibits fatty acid oxidation and esterification, and gluconeogenesis in isolated hepatocytes from starved rats

1996 • 34 citations

The interaction of acyl-CoA with acyl-CoA binding protein and carnitine palmitoyltransferase I

2001 • 34 citations

Inhibition of fatty acid oxidation by 2-bromooctanoate. Including effects of bromooctanoate on ketogenesis and gluconeogenesis.

1979 • 34 citations

Redox control of β‐oxidation in rat liver mitochondria

1994 • 34 citations

Computer simulation of metabolism in palmitate-perfused rat heart. I. Palmitate oxidation

1983 • 33 citations

Mitochondrial β-Oxidation of 2-Methyl Fatty Acids in Rat Liver

1995 • 33 citations

Ophthalmic pathology in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency caused by the G1528C mutation

1998 • 33 citations

Isolation and purification of long chain fatty acyl coenzyme A ligase from rat liver mitochondria.

1979 • 32 citations

Interaction between citrate synthase and thiolase.

1985 • 32 citations

Substrate Channeling of NADH in Mitochondrial Redox Processes

1992 • 32 citations

Expression of novel isoforms of carnitine palmitoyltransferase I (CPT-1) generated by alternative splicing of the CPT-Iβ gene

1998 • 32 citations

Rapid switch of hepatic fatty acid metabolism from oxidation to esterification during diurnal feeding of meal-fed rats correlates with changes in the properties of acetyl-CoA carboxylase, but not of carnitine palmitoyltransferase I

1993 • 32 citations

Rat Liver Mitochondrial Contact Sites and Carnitine Palmitoyltransferase-I

2001 • 31 citations

Regulation of ATP-sensitive K⁺channels by protein kinase C in murine colonic myocytes

2001 • 31 citations

Mechanisms of the metabolic disturbances caused by hypoglycin and by pent-4-enoic acid in vivo studies

1978 • 31 citations

Stereospecificity of the inhibition by etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes

1991 • 31 citations

Carnitine palmitoyltransferase in human erythrocyte membrane. Properties and malonyl-CoA sensitivity

1991 • 31 citations

Carnitine palmitoyltransferase activities: Effects of serum albumin, acyl-CoA binding protein and fatty acid binding protein

1994 • 31 citations

Inhibition of enoyl-CoA hydratase by long-chain l-3-hydroxyacyl-CoA and its possible effect on fatty acid oxidation

1992 • 30 citations

Intermediate Channeling on the Trifunctional β-Oxidation Complex from Pig Heart Mitochondria

1996 • 30 citations

Solubilization and reconstitution of rat liver mitochondrial carnitine acylcarnitine translocase

1985 • 30 citations

Impaired Ketogenesis in Carnitine Depletion Caused by Short-Term Administration of Pivalic Acid Prodrug

1994 • 30 citations

The antagonism of the toxicity of hypoglycin by glycine

1981 • 29 citations

The occurrence of intermediates in mitochondrial fatty acid oxidation

1974 • 29 citations

Current Views of Fatty Acid Oxidation and Ketogenesis: From Organelles To Point Mutations

2013 • 29 citations

Cloning and characterization of a hormonally regulated rat long chain acyl-CoA synthetase

2001 • 29 citations

Carnitine Palmitoyl Transferase I and the Control of β-Oxidation in Heart Mitochondria

2001 • 29 citations

Induction of hepatic cytosolic fatty acid binding protein with clofibrate accelerates both membrane and cytoplasmic transport of palmitate

2000 • 28 citations

Activation of Protein Phosphatase 2A by the Fe2+/Ascorbate System

1998 • 28 citations

Spiropentylacetyl-CoA, A Mechanism-Based Inactivator of Acyl-CoA Dehydrogenases

1998 • 28 citations

Clinical consequences of defects in peroxisomal β-oxidation

2001 • 28 citations

Moderate Carnitine Depletion and Long-Chain Fatty Acid Oxidation, Exercise Capacity, and Nitrogen Balance in the Rat

1994 • 28 citations

[15] Long-chain fatty acyl-CoA synthetase from rat liver microsomes

1975 • 28 citations

Studies with (+)—Octanoylcarnitine in Experimental Diabetic Ketoacidosis

1974 • 27 citations

Evaluation of electron-transfer flavoprotein and α-lipoamide dehydrogenase redox states by two-channel fluorimetry and its application to the investigation of β-oxidation

1988 • 27 citations

Isolation and characterization of 3-hydroxyacyl coenzyme A dehydrogenase-binding protein from pig heart inner mitochondrial membrane.

1986 • 27 citations

Modelling intracellular fatty acid transport: possible mechanistic role of cytoplasmic fatty acid-binding protein

1997 • 26 citations

The source of malonyl‐CoA in rat heart

1986 • 26 citations

The relationship between mitochondrial activation and toxicity of some substituted carboxylic acids

1994 • 26 citations

Overexpression of acyl‐CoA binding protein and its effects on the flux of free fatty acids in McA‐RH 7777 cells

2001 • 26 citations

Some effects of α-bromopalmitate, an inhibitor of fatty acid oxidation, on carbohydrate metabolism in the rat

1968 • 26 citations

Control of mitochondrial β-oxidation: sensitivity of the trifunctional protein to [NAD+]/[NADH] and [acetyl-CoA]/[CoA]

1998 • 25 citations

Spiropentaneacetic acid as a specific inhibitor of medium-chain acyl-CoA dehydrogenase

1991 • 25 citations

Expression and Possible Role of Muscle-Type Carnitine Palmitoyltransferase I during Sperm Development in the Rat1

1998 • 25 citations

Effects of maleate on the content of CoA and its derivatives in rat kidney mitochondria.

1981 • 25 citations

In vitro lipid metabolism in the rat pancreas I. Basal lipid metabolism

1979 • 25 citations

New developments in neonatal screening

1997 • 25 citations

The Effect of Carnitine on Ketogenesis in Perfused Livers from Juvenile Visceral Steatosis Mice with Systemic Carnitine Deficiency

1997 • 24 citations

H₂O₂and ethanol act synergistically to gate ryanodine receptor/calcium-release channel

2000 • 24 citations

Kinetic Properties of Carnitine Palmitoyltransferase I in Cultured Neonatal Rat Cardiac Myocytes

1994 • 24 citations

Intramitochondrial control of the oxidation of hexadecanoate in skeletal muscle. A study of the acyl-CoA esters which accumulate during rat skeletal-muscle mitochondrial β-oxidation of [U-14C]hexadecanoate and [U-14C]hexadecanoyl-carnitine

1993 • 24 citations

Carnitine palmitoyl transferase I and the control of myocardial β-oxidation flux

2001 • 24 citations

Dependence of mitochondrial coenzyme A uptake on the membrane electrical gradient

1989 • 24 citations

Alternative Translation Initiation Generates Acyl-CoA Synthetase 3 Isoforms with Heterogeneous Amino Termini

1997 • 24 citations

Carnitine palmitoyl transferase I and the control of myocardial β-oxidation flux

2001 • 23 citations

A 22 kDa polyanion inhibits carnitine‐dependent fatty acid oxidation in rat liver mitochondria

1999 • 23 citations

The inhibition of L-3-hydroxyacyl-CoA dehydrogenase by acetoacetyl-CoA and the possible effect of this inhibitor on fatty acid oxidation

1974 • 23 citations

Metabolism of pent-4-enoate in rat heart. Reduction of the double bond

1981 • 23 citations

Medium-Chain Acyl Coenzyme A Dehydrogenase Deficiency

2001 • 23 citations

The Effect of Fasting/Refeeding and Insulin Treatment on the Expression of the Regulatory Genes of Ketogenesis in Intestine and Liver of Suckling Rats

1997 • 23 citations

Kinetic characterization of branched chain ketoacid dehydrogenase

1991 • 22 citations

Fasting medium chain acyl-coenzyme a dehydrogenase-deficient children can make ketones

2001 • 21 citations

Elucidation of the Mechanism by Which (+)-Acylcarnitines Inhibit Mitochondrial Fatty Acid Transport

2000 • 21 citations

A New Inhibitor of Mitochondrial Fatty Acid Oxidation

1996 • 21 citations

The role of mitochondrial HMG-CoA synthase in regulation of ketogenesis.

1994 • 20 citations

The intracellular localization of long-chain acyl-CoA synthetase in brown adipose tissue

1975 • 20 citations

Evidence for net uptake and efflux of mitochondrial coenzyme A

1991 • 19 citations

On the rate-limiting step in the transfer of long-chain acyl groups across the inner membrane of brown adipose tissue mitochondria

1978 • 19 citations

Human Forearm Arteriovenous Differences of Carnitine, Short-Chain Acylcarnitine and Long-Chain Acylcarnitine

1989 • 19 citations

Characterization of rat liver malonyl-CoA decarboxylase and the study of its role in regulating fatty acid metabolism

2000 • 18 citations

MALDI-TOF and electrospray tandem mass spectrometric analysis of fatty acyl-CoA esters

1997 • 18 citations

Pivalate Affects Carnitine Status but Causes No Severe Metabolic Changes in Rat Liver

1996 • 18 citations

Deacylation of acetyl-coenzyme A and acetylcarnitine by liver preparations

1978 • 18 citations

Long-chain acyl-CoA synthetase and ‘outer’ carnitine long-chain acyltransferase activities of intact brown adipose tissue mitochondria

1978 • 17 citations

Rat carnitine palmitoyltransferase Iβ mRNA splicing isoforms

1998 • 17 citations

Computer simulation of metabolism in palmitate-perfused rat heart. III. Sensitivity analysis

1983 • 17 citations

Stimulation of islet protein kinase C translocation by palmitate requires metabolism of the fatty acid

1997 • 17 citations

Carnitine and Carnitine Transferases in the Intestinal Mucosa of Suckling Rats

1985 • 16 citations

4-Bromo-2-octenoic acid specifically inactivates 3-ketoacyl-CoA thiolase and thereby fatty acid oxidation in rat liver mitochondria

1988 • 16 citations

Insulin-independent and extremely rapid switch in the partitioning of hepatic fatty acids from oxidation to esterification in starved-refed diabetic rats. Possible roles for changes in cell pH and volume

1995 • 15 citations

[38] Acetyl-CoA synthetase from bakers' yeast (Saccharomyces cerevisiae)

1981 • 15 citations

Cloning and expression of rat pancreatic β-cell malonyl-CoA decarboxylase

1999 • 14 citations

No correlation between changes in fatty acid-binding protein content and fatty acid oxidation capacity of rat tissues in experimental diabetes

1996 • 14 citations

Malonyl-CoA metabolism in cardiac myocytes

2000 • 14 citations

Design of novel agents for the therapy of non-insulin dependent diabetes mellitus (NIDDM)

1993 • 14 citations

Metabolic control analysis of hepatic β-oxidation: the top-down approach

1994 • 13 citations

Application of a new method for the sensitive detection and quantification of acyl-CoA esters in Arabidopsis thaliana seedlings and mature leaves

2000 • 13 citations

The measurement of mitochondrial β-oxidation by release of 3H2O from [9,10-3H]hexadecanoate: Application to skeletal muscle and the use of inhibitors as models of metabolic disease

1992 • 12 citations

Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues

2000 • 12 citations

Current Views of Fatty Acid Oxidation and Ketogenesis

2002 • 12 citations

Mitochondrial, but not peroxisomal, beta-oxidation of fatty acids is conserved in coenzyme A-deficient rat liver.

1997 • 12 citations

The Inhibition of Long-Chain Fatty Acyl-CoA Synthetase by Enoximone in Rat Heart Mitochondria

1992 • 12 citations

CURRENT VIEWS OF FATTY ACID OXIDATION AND KETOGENESIS

1999 • 12 citations

Comparisons of flux control exerted by mitochondrial outer‐membrane carnitine palmitoyltransferase over ketogenesis in hepatocytes and mitochondria isolated from suckling or adult rats

1999 • 12 citations

A Profile of Cerebral and Hepatic Carnitine, Ammonia, and Energy Metabolism in a Model of Organic Aciduria: BALB/cByJ Mouse with Short-Chain Acyl-CoA Dehydrogenase Deficiency

1993 • 12 citations

Processivity and fatty acid oxidation

1994 • 12 citations

The peroxisomal proliferator clofibrate enhances the hepatic cytoplasmic movement of fatty acids in rats

2001 • 11 citations

Evaluation of the Affinity and Turnover Number of Both Hepatic Mitochondrial and Microsomal Carnitine Acyltransferases: Relevance to Intracellular Partitioning of Acyl-CoAs

1999 • 11 citations

Flux control exerted by overt carnitine palmitoyltransferase over palmitoyl-CoA oxidation and ketogenesis is lower in suckling than in adult rats

1996 • 11 citations

The role of mitochondrial adenine nucleotide pool on the regulation of fatty acid and α-ketoglutarate oxidation

1972 • 10 citations

Studies on chemical and enzymatic synthesis of maleyl-CoA.

1981 • 10 citations

Preliminary evidence for the existence of specific functional assemblies between enzymes of the β-oxidation pathway and the respiratory chain

2000 • 9 citations

Intermediates of myocardial mitochondrial β-oxidation: possible channelling of NADH and of CoA esters

1999 • 9 citations

Characterization of the inhibitor sensitivity of the coenzyme a transport system in isolated rat heart mitochondria

1992 • 9 citations

Atypical expression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in subcutaneous adipose tissue of male rats

1999 • 8 citations

Phytanic acid α-oxidation in rat liver mitochondria

1994 • 8 citations

Effect of carnitine acetyltransferase inhibition on rat hepatocyte metabolism

1991 • 7 citations

A malonyl-CoA-binding protein from liver

1987 • 7 citations

Enoximone inhibits hepatic mitochondrial long-chain acyl-CoA synthetase

1994 • 7 citations

Purification and Properties of 3-Hydroxyacyl Coenzyme A Dehydrogenase-Binding Protein from Rat Liver Mitochondria

1995 • 6 citations

Participation of carnitine palmitoyltransferase in the synthesis of dipalmitoylphosphatidylcholine in rat alveolar type II cells.

2001 • 6 citations

Intermediates of mitochondrial β-oxidation

1994 • 6 citations

Novel methylenecyclopropyl‐based acyl‐CoA dehydrogenase inhibitor

1998 • 5 citations

Investigation of cardiac metabolism using stable isotopes and mass spectrometry

1993 • 5 citations

Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues

2000 • 5 citations

Top-down regulation analyses of palmitoyl-CoA oxidation and ketogenesis in isolated rat liver mitochondria

1995 • 4 citations

4-Bromotiglic Acid, a Novel Inhibitor of Thiolases and a Tool for Assessing the Cooperation between the Membrane-Bound and Soluble β-Oxidation Systems of Rat Liver Mitochondria

1998 • 3 citations

The Conserved Serine-Threonine-Serine Motif of the Carnitine Acyltransferases Is Involved in Carnitine Binding and Transition-State Stabilization: A Site-Directed Mutagenesis Study

1997 • 2 citations