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Nitric oxide scavengers in the treatment of shock associated with systemic inflammatory response syndrome

Data up to Jan 2025

Published1999
Citations38
References93

Total Citations Per Year

Abstract

References (93)

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference

1992 • 4,689 citations

The Natural History of the Systemic Inflammatory Response Syndrome (SIRS)

1995 • 2,007 citations

Prospective Trial of Supranormal Values of Survivors as Therapeutic Goals in High-Risk Surgical Patients

1988 • 1,808 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

Pathogenetic Mechanisms of Septic Shock

1993 • 1,577 citations

Septic Shock in Humans

1990 • 1,170 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

A Randomized Clinical Trial of the Effect of Deliberate Perioperative Increase of Oxygen Delivery on Mortality in High-Risk Surgical Patients

1993 • 949 citations

Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock*

2004 • 911 citations

Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase.

1994 • 819 citations

Simulation of the diffusion and reaction of endogenously produced nitric oxide.

1994 • 699 citations

Oxidation of nitrogen oxides by bound dioxygen in hemoproteins

1981 • 633 citations

Nitrogen Oxide Levels in Patients After Trauma and During Sepsis

1991 • 609 citations

Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.bul.NO (nitric oxide) through a radical reaction

1993 • 569 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia.

1996 • 522 citations

Serial cardiovascular variables in survivors and nonsurvivors of human septic shock

1987 • 502 citations

Tissue injury caused by deposition of immune complexes is L-arginine dependent.

1991 • 436 citations

Practice parameters for hemodynamic support of sepsis in adult patients in sepsis

1999 • 433 citations

The kinetics and equilibria of the reactions of nitric oxide with sheep haemoglobin

1957 • 385 citations

Maximizing oxygen delivery in critically ill patients

1996 • 357 citations

Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia

1992 • 327 citations

Mechanism of Nitric Oxide–Induced Vasodilatation

1999 • 291 citations

Cooperativity in the dissociation of nitric oxide from hemoglobin.

1976 • 289 citations

Physiological and metabolic correlations in human sepsis. Invited commentary.

1979 • 275 citations

Overproduction of Nitric Oxide in Cytokine-Mediated and Septic Shock

1992 • 271 citations

Anterior pituitary function during critical illness and dopamine treatment

1996 • 267 citations

Conformation, co-operativity and ligand binding in human hemoglobin

1975 • 263 citations

Reaction of nitric oxide with heme proteins and model compounds of hemoglobin

1987 • 252 citations

Physiological and metabolic correlations in human sepsis

1980 • 244 citations

Development and Effectiveness of an Anesthesia Preoperative Evaluation Clinic in a Teaching Hospital

1997 • 243 citations

Hemodynamic determinants of mortality in human septic shock

1986 • 243 citations

Tolerance to dobutamine after a 72 hour continuous infusion

1980 • 240 citations

L-arginine

1995 • 208 citations

An open-label dose escalation study of the nitric oxide synthase inhibitor, NG-methyl-L-arginine hydrochloride (546C88), in patients with septic shock

1999 • 196 citations

Spin trapping of nitric oxide produced in vivo in septic‐shock mice

1994 • 174 citations

Intestinal vasoconstriction after hemorrhage: roles of vasopressin and angiotensin

1970 • 162 citations

Ruthenium complexes as nitric oxide scavengers: a potential therapeutic approach to nitric oxide‐mediated diseases

1997 • 138 citations

Catecholaminergic depressant effects on bulbar respiratory mechanisms

1979 • 137 citations

Formation of Free Radicals and Nitric Oxide Derivative of Hemoglobin in Rats During Shock Syndrome

1990 • 135 citations

Nitric oxide regulates endotoxin-induced TNF-alpha production by human neutrophils.

1994 • 134 citations

Hemoglobin-based red cell substitutes

1991 • 128 citations

Increased Nitric Oxide Production in Patients with Hypotension during Hemodialysis

1995 • 124 citations

Peripheral vascular resistance in septic shock: its relation to outcome

1988 • 120 citations

Detection of nitric oxide production in lipopolysaccharide-treated rats by ESR using carbon monoxide hemoglobin

1992 • 115 citations

Septic shock and multiple organ failure

1991 • 114 citations

Angiotensin II, vasopressin, and sympathetic activity in conscious rats with endotoxemia

1985 • 114 citations

The effect of Adrenaline upon Cardiovascular and Metabolic Functions in Man

1985 • 107 citations

Influence of Epinephrine, Norepinephrine, and Isoproterenol on Glucose Homeostasis in Normal Man

1980 • 103 citations

THE EFFECT OF NORADRENALINE INFUSION ON THE RELATION BETWEEN PULMONARY VENTILATION AND THE ALVEOLAR Po2 AND Pco2, IN MAN

1963 • 102 citations

Round table conference on clinical trials for the treatment of sepsis

1995 • 98 citations

Nitrosyliron(III) hemoglobin: autoreduction and spectroscopy

1986 • 98 citations

Nitric oxide and shock

1997 • 87 citations

The dissociation of NO from nitrosylhemoglobin.

1978 • 86 citations

cAMP enhances inducible nitric oxide synthase mRNA stability in cardiac myocytes

1995 • 80 citations

Hydroxocobalamin (vitamin B12a) prevents and reverses endotoxin-induced hypotension and mortality in rodents: role of nitric oxide.

1995 • 79 citations

Adrenergic mechanisms of catecholamine action on glucose homeostasis in man

1980 • 76 citations

Nitric oxide hemoglobin in mice and rats in endotoxic shock

1991 • 76 citations

Nitric Oxide Binding to Human Ferrihemoglobins Cross-Linked between Either α or β Subunits

1993 • 71 citations

Early hemodynamic course of septic shock

1995 • 66 citations

Tissue hypoxia (3rd European Consensus Conference in Intensive Care Medicine Organized by the Soci�t� de R�animation de Langue Fran�aise Co-sponsored by the American Thoracic Society In conjunction with the European Society of Intensive Care Medicine)

1996 • 65 citations

[13] Preparation and properties of hemoglobin modified with derivatives of pyridoxal

1981 • 63 citations

Metabolic effects of dobutamine in normal man

1992 • 61 citations

Epinephrine and the regulation of glucose metabolism: Effect of diabetes and hormonal interactions

1980 • 59 citations

Third European Consensus Conference in Intensive Care Medicine. Tissue hypoxia: How to detect, how to correct, how to prevent. Société de Réanimation de Langue Française. The American Thoracic Society. European Society of Intensive Care Medicine.

1996 • 55 citations

Influence of Small Increments of Epinephrine on Glucose Tolerance in Normal Humans

1980 • 55 citations

Cardiovascular dysfunction in septic shock: new insights into a deadly disease

1985 • 53 citations

From the Bench to the Bedside: The Future of Sepsis Research

1997 • 53 citations

Cell-Free Hemoglobin Reverses the Endotoxin-Mediated Hyporesponsivity of Rat Aortic Rings to α-Adrenergic Agents

1994 • 53 citations

Cardiovascular parameters and scoring systems in the evaluation of response to therapy in sepsis and septic shock

1990 • 50 citations

Intestinal Bleeding and Perforation Complicating Treatment with Vasoconstrictors

1959 • 46 citations

Recombinant Human Hemoglobin Inhibits Both Constitutive and Cytokine-Induced Nitric Oxide-Mediated Relaxation of Rabbit Isolated Aortic Rings

1994 • 44 citations

Recombinant Human Hemoglobin Inhibits Both Constitutive and Cytokine-Induced Nitric Oxide-Mediated Relaxation of Rabbit Isolated Aortic Rings

1994 • 43 citations

Myocardial beta adrenergic receptor coupling to adenylate cyclase during developing septic shock.

1990 • 43 citations

Oxalated pyridoxalated hemoglobin polyoxyethylene conjugate normalizes the hyperdynamic circulation in septic sheep

1997 • 42 citations

Multiple Extremity Amputations in Hypotensive Patients Treated With Dopamine

1980 • 41 citations

Pyridoxalated hemoglobin polyoxyethylene conjugate reverses hyperdynamic circulation in septic sheep

1998 • 37 citations

Protein kinase A activation is required for IL-1-induced nitric oxide production by cardiac myocytes

1996 • 36 citations

CONTINUOUS INFUSION OF PYRIDOXALATED HEMOGLOBIN POLYOXYETHYLENE CONJUGATE IN HYPERDYNAMIC SEPTIC SHEEP

1998 • 32 citations

Studies on the Mechanism for the Calorigenic Effect of Adrenaline in Man

1966 • 32 citations

Comparison of the haemodynamic effects of nitric oxide synthase inhibition and nitric oxide scavenging in endotoxaemic sheep

1998 • 30 citations

Effects of Pyridoxalated Hemoglobin Polyoxyethylene Conjugate and Other Hemoglobin‐Related Substances on Arterial Blood Pressure in Anesthetized and Conscious Rats

1995 • 28 citations

Pyridoxalated hemoglobin polyoxyethylene conjugate does not restore hypoxic pulmonary vasoconstriction in ovine sepsis

1997 • 25 citations

Cell surface adrenergic receptor stimulation modifies the endothelial response to SIRS. Systemic Inflammatory Response Syndrome.

1996 • 24 citations

Redox Reactivity of Modified Hemoglobins with Hydrogen Peroxide and Nitric Oxide: Toxicological Implications

1994 • 23 citations

Reversal of ‘Refractory Septic Shock’ by Infusion of Amrinone and Angiotensin II in an Anthracycline-Treated Patient

1995 • 21 citations

Alterations in Vascular Reactivity in Sepsis and Endotoxemia

1989 • 20 citations

Acellular and Cellular Hemoglobin Solutions as Vasoconstrictive Factor

1994 • 20 citations

Characteristics of the Dopaminergic and Noradrenergic Systems of the Pancreatic Islets

1979 • 16 citations

Reduced myocardial response to calcium during endotoxin shock in the cat.

1980 • 14 citations

Nitrogen Monoxide-Related Disease and Nitrogen Monoxide Scavengers as Potential Drugs

2018 • 12 citations

Cardiovascular Dysfunction in Humans with Septic Shock

1986 • 9 citations

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