An open-label dose escalation study of the nitric oxide synthase inhibitor, NG-methyl-L-arginine hydrochloride (546C88), in patients with septic shock

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study

1993 • 6,337 citations

A New Simplified Acute Physiology Score (SAPS II) Based on a European/North American Multicenter Study

1993 • 5,263 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

1989 • 1,837 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin

1991 • 1,611 citations

Pathogenetic Mechanisms of Septic Shock

1993 • 1,577 citations

Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein

1996 • 1,217 citations

Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group

1994 • 920 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Confirmatory interleukin-1 receptor antagonist trial in severe sepsis

1997 • 822 citations

Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome

1995 • 805 citations

Pulmonary Hypertension in Severe Acute Respiratory Failure

1977 • 729 citations

Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome

1994 • 714 citations

Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group.

1989 • 709 citations

Nitrogen Oxide Levels in Patients After Trauma and During Sepsis

1991 • 609 citations

Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock

1990 • 596 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase

1995 • 540 citations

Sepsis syndrome

1989 • 523 citations

Effects of a nitric oxide synthase inhibitor in humans with septic shock

1994 • 521 citations

Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans.

1994 • 518 citations

Norepinephrine or Dopamine for the Treatment of Hyperdynamic Septic Shock?

1993 • 454 citations

Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations

1997 • 400 citations

Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes

1991 • 395 citations

Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock

1996 • 368 citations

A second large controlled clinical study of E5, a monoclonal antibody to endotoxin

1995 • 348 citations

Inhibition of nitric oxide synthesis increases blood pressure in healthy humans

1993 • 278 citations

Differential Expression of iNOS and cNOS mRNA in Human Vascular Smooth Muscle Cells and Endothelial Cells under Normal and Inflammatory Conditions

1993 • 238 citations

Nitric Oxide Inhibits the Positive Inotropic Response to β-Adrenergic Stimulation in Humans With Left Ventricular Dysfunction

1995 • 218 citations

A Rapid and Simple Method for the Measurement of Nitrite and Nitrate in Plasma by High Performance Capillary Electrophoresis

1994 • 198 citations

Hypoxic pulmonary vasoconstriction is enhanced by inhibition of the synthesis of an endothelium derived relaxing factor

1989 • 198 citations

Nitric oxide synthesis serves to reduce hepatic damage during acute murine endotoxemia

1992 • 172 citations

Customized probability models for early severe sepsis in adult intensive care patients. Intensive Care Unit Scoring Group.

1995 • 171 citations

Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis

1992 • 143 citations

Time‐dependent enhancement or inhibition of endotoxin‐induced vascular injury in rat intestine by nitric oxide synthase inhibitors

1994 • 137 citations

Induction of NG-monomethyl-L-arginine uptake: a mechanism for differential inhibition of NO synthases?

1995 • 134 citations

Customized probability models for early severe sepsis in adult intensive care patients. Intensive Care Unit Scoring Group

1995 • 134 citations

Nitric oxide and the haemodynamic profile of endotoxin shock in the conscious mouse

1998 • 88 citations

Characterization of endothelial cell amino acid transport systems involved in the actions of nitric oxide synthase inhibitors.

1993 • 85 citations

Effects of L-arginine and L-nitro-arginine treatment on blood pressure and cardiac output in a rabbit endotoxin shock model

1994 • 81 citations

A new approach in the treatment of hypotension in human septic shock by NG-monomethyl-L-arginine, an inhibitor of the nitric oxide synthetase

1993 • 67 citations

N sup G-methyl-L-arginine, an inhibitor of nitric oxide synthase, reverses interleukin-2-induced hypotension

1995 • 66 citations

Cardiovascular Dysfunction in Septic Shock

1991 • 63 citations

Role of nitric oxide in the vascular dysfunction of septic shock

1995 • 63 citations

Hemodynamic and gas exchange responses to inhalation of nitric oxide in patients with the acute respiratory distress syndrome and in hypoxemic patients with chronic obstructive pulmonary disease

1997 • 34 citations

Plasma nitrate concentration and urinary nitrate excretion in patients with gastroenteritis

1995 • 27 citations

THE NITRIC OXIDE SYNTHASE INHIBITOR 546C88 PROMOTES THE RESOLUTION OF SHOCK IN PATIENTS WITH SEVERE SEPSIS

1998 • 14 citations