Pyridoxalated hemoglobin polyoxyethylene conjugate reverses hyperdynamic circulation in septic sheep

Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.

1994 • 409 citations

Alterations in nitric oxide production in various forms of circulatory shock.

1995 • 321 citations

Hemoglobin provides protection against lethal endotoxemia in rats: the role of heme oxygenase-1.

1995 • 309 citations

Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin

1993 • 308 citations

Role of Poly-ADP Ribosyltransferase Activation in the Vascular Contractile and Energetic Failure Elicited by Exogenous and Endogenous Nitric Oxide and Peroxynitrite

1996 • 254 citations

Systemic complement activation, lung injury, and products of lipid peroxidation.

1985 • 237 citations

A role for endothelin and nitric oxide in the pressor response to diaspirin cross-linked hemoglobin.

1993 • 226 citations

L-arginine

1995 • 208 citations

Limitations of the efficacy of hemoglobin-based oxygen-carrying solutions

1995 • 146 citations

Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia

1994 • 140 citations

Role of endothelin in the cardiovascular effects of diaspirin crosslinked and stroma reduced hemoglobin

1996 • 114 citations

Inhibition of endothelial derived relaxing factor (EDRF) aggravates ischemic acute renal failure in anesthetized rats

1993 • 84 citations

Regional blood flow alterations after bovine fumaryl beta beta-crosslinked hemoglobin transfusion and nitric oxide synthase inhibition

1996 • 79 citations

Ultrapure, stroma-free, polymerized bovine hemoglobin solution: Evaluation of renal toxicity

1989 • 67 citations

Virulence and the Role of Iron in Pseudomonas aeruginosa Infection

1974 • 65 citations

Haemoglobin-based blood substitutes and sepsis

1995 • 60 citations

Cell-Free Hemoglobin Reverses the Endotoxin-Mediated Hyporesponsivity of Rat Aortic Rings to α-Adrenergic Agents

1994 • 53 citations

Yohimbine modulates diaspirin crosslinked hemoglobin-induced systemic hemodynamics and regional circulatory effects

1995 • 51 citations

Effect of human hemoglobin on systemic and regional hemodynamics in a porcine model of endotoxemic shock

1996 • 49 citations

Influence of endothelium-derived relaxing factor on renal microvessels and pressure-dependent vasodilation

1993 • 49 citations

Nitric oxide synthase inhibition during experimental sepsis improves renal excretory function in the presence of chronically increased atrial natriuretic peptide

1996 • 45 citations

NITRIC OXIDE SYNTHASE INHIBITION VERSUS NOREPINEPHRINE IN OVINE SEPSIS: EFFECTS ON REGIONAL BLOOD FLOW

1996 • 44 citations

Coronary Vasoconstrictor Activity of Purified and Modified Human Hemoglobin

1990 • 39 citations

Very large-scale, randomized, clinical trials in sepsis and septic shock

1994 • 34 citations

Sepsis and its complications: clinical definitions and therapeutic prospects.

1994 • 28 citations

Effect of PGE1 on Altered Distribution of Regional Blood Flows in Hyperdynamic Sepsis

1991 • 24 citations

Use of nitric oxide synthase inhibitors in animal models of sepsis.

1995 • 23 citations

Reactions of Nitric Oxide and Hydrogen Peroxide with Hemoglobin‐Based Blood Substitutes

1994 • 23 citations

Liver function and morphology after resuscitation from severe hemorrhagic shock with hemoglobin solutions or autologous blood

1996 • 19 citations

Regulation and functions of nitric oxide in the liver in sepsis and inflammation.

1995 • 17 citations

Infusion of stroma-free cross-linked hemoglobin during acute gram-negative bacteremia.

1993 • 16 citations

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