A Randomized Clinical Trial of the Effect of Deliberate Perioperative Increase of Oxygen Delivery on Mortality in High-Risk Surgical Patients

APACHE II-A Severity of Disease Classification System

1986 • 12,607 citations

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

1977 • 8,468 citations

Analysis of serial measurements in medical research.

1990 • 3,078 citations

Multifactorial Index of Cardiac Risk in Noncardiac Surgical Procedures

1977 • 2,734 citations

Prospective Trial of Supranormal Values of Survivors as Therapeutic Goals in High-Risk Surgical Patients

1988 • 1,808 citations

Perioperative Cardiac Morbidity

1990 • 1,202 citations

The Effects of Vasodilation with Prostacyclin on Oxygen Delivery and Uptake in Critically Ill Patients

1987 • 559 citations

Elevation of Cardiac Output and Oxygen Delivery Improves Outcome in Septic Shock

1992 • 555 citations

Role of Oxygen Debt in the Development of Organ Failure Sepsis, and Death in High-Risk Surgical Patients

1992 • 426 citations

Tissue oxygen debt as a determinant of lethal and nonlethal postoperative organ failure

1988 • 410 citations

Physiologic Patterns in Surviving and Nonsurviving Shock Patients

1973 • 403 citations

Preoperative Optimization of Cardiovascular Hemodynamics Improves Outcome in Peripheral Vascular Surgery

1991 • 373 citations

A Review of Pulmonary Artery Catheterization in 6,245 Patients

1984 • 301 citations

Physiologic Consequences of Positive End-Expiratory Pressure (PEEP) Ventilation

1973 • 286 citations

Prospective Trial of Supranormal Values as Goals of Resuscitation in Severe Trauma

1992 • 270 citations

Aortic Aneurysm Repair

1980 • 251 citations

Death by Pulmonary Artery Flow-Directed Catheter (editorial)

1987 • 239 citations

Clinical trial of survivorsʼ cardiorespiratory patterns as therapeutic goals in critically ill postoperative patients

1982 • 224 citations

Dopexamine: a novel agonist at peripheral dopamine receptors and β₂‐adrenoceptors

1985 • 202 citations

Use of physiologic monitoring to predict outcome and to assist in clinical decisions in critically ill postoperative patients

1983 • 183 citations

Effects of adrenergic stimulation on ventilation in man

1972 • 175 citations

Oxygen consumption is linearly related to O2 supply in critically ill patients

1986 • 137 citations

CLINICAL CARDIOVASCULAR PHARMACOLOGY OF DOBUTAMINE A SELECTIVE INOTROPIC CATECHOLAMINE

1974 • 127 citations

Supply Dependency of Oxygen Uptake in ARDS: Myth or Reality?

1984 • 120 citations

The effect of Adrenaline upon Cardiovascular and Metabolic Functions in Man

1985 • 107 citations

Assessment of Myocardial Performance and Optimal Volume Loading During Elective Abdominal Aortic Aneurysm Resection

1977 • 101 citations

Cardiovascular pharmacology of dopexamine in low output congestive heart failure

1988 • 97 citations

Acute haemodynamic and metabolic effects of dopexamine, a new dopaminergic receptor agonist, in patients with chronic heart failure.

1985 • 82 citations

Hemodynamic and metabolic effects of morphine in the critically ill.

1981 • 82 citations

Morphine and postoperative rewarming in critically ill patients.

1983 • 80 citations

Physiologic monitoring goals for the critically ill patient.

1978 • 80 citations

Epinephrine sensitivity with respect to metabolic rate and other variables in women

1983 • 79 citations

Circulatory response to trauma of surgical operations.

1960 • 72 citations

Physiological scoring systems and audit

1993 • 62 citations

Metabolic effects of dobutamine in normal man

1992 • 61 citations

Use of continuous noninvasive measurement of oxygen consumption in patients with adult respiratory distress syndrome following shock of various etiologies

1991 • 53 citations

The Dependency of Oxygen Consumption on Oxygen Delivery in Critically III Postoperative Patients Is Mimicked by Variations in Sedation

1992 • 52 citations

Persistence of supply dependency of oxygen uptake at high levels of delivery in adult respiratory distress syndrome

1991 • 48 citations

EFFECT OF DOBUTAMINE ON OXYGEN SUPPLY AND UPTAKE IN HEALTHY VOLUNTEERS

1992 • 47 citations

Dopexamine hydrochloride in chronic congestive heart failure with improved cardiac performance without increased metabolic cost

1988 • 32 citations

Studies on the Mechanism for the Calorigenic Effect of Adrenaline in Man

1966 • 32 citations

Preoperative Assessment of High-Risk Surgical Patients

1985 • 30 citations

The use of dopexamine hydrochloride to increase oxygen delivery perioperatively.

1993 • 21 citations

Evaluation of right heart catheterization in critically ill patients ONTARIO INTENSIVE CARE STUDY GROUP

1992 • 20 citations

Dopexamine Hydrochloride: A Novel Dopamine Receptor Agonist for the Acute Treatment of Low Cardiac Output States

1989 • 19 citations

Renal hemodynamic effects of dopexamine hydrochloride

1988 • 13 citations

Physiologic Assessment of Surgical Diagnosis-Related Groups

1985 • 13 citations

Effects of temperature on ileal blood flow and oxygenation

1985 • 11 citations

Role of preoperative hemodynamic monitoring in intraoperative fluid management.

1986 • 7 citations