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1998 • 8,909 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

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Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

1997 • 1,116 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Inactivation of Bcl-2 by phosphorylation.

1995 • 744 citations

Bcl-2 Phosphorylation Required for Anti-apoptosis Function

1997 • 540 citations

Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro.

1993 • 503 citations

Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene

1993 • 495 citations

Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases.

1991 • 446 citations

A Functional Role for Mitochondrial Protein Kinase Cα in Bcl2 Phosphorylation and Suppression of Apoptosis

1998 • 446 citations

Ras effectors

1996 • 445 citations

Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease.

1997 • 439 citations

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

1998 • 437 citations

Bcl-2 Undergoes Phosphorylation by c-Jun N-terminal Kinase/Stress-activated Protein Kinases in the Presence of the Constitutively Active GTP-binding Protein Rac1

1997 • 406 citations

Ceramide Induces Bcl2 Dephosphorylation via a Mechanism Involving Mitochondrial PP2A

1999 • 340 citations

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

1999 • 338 citations

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.

1996 • 335 citations

Bcl-2 and Bax interactions in mitochondria probed with green fluorescent protein and fluorescence resonance energy transfer

1998 • 301 citations

Angiotensin Type 2 Receptor Dephosphorylates Bcl-2 by Activating Mitogen-activated Protein Kinase Phosphatase-1 and Induces Apoptosis

1997 • 301 citations

Identification of a novel regulatory domain in Bcl-xL and Bcl-2

1997 • 287 citations

Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis.

1994 • 222 citations

Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells.

1994 • 218 citations

THE ISOLATION AND PROPERTIES OF CARDIAC RIBOSOMES AND POLYSOMES

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Prohibitin, an antiproliferative protein, is localized to mitochondria

1995 • 184 citations

Reversible Phosphorylation of Bcl2 following Interleukin 3 or Bryostatin 1 Is Mediated by Direct Interaction with Protein Phosphatase 2A

1998 • 143 citations

Phosphorylation of Bcl-2 Protein and Association with p21Ras in Ras-induced Apoptosis

1996 • 132 citations

Functional Dissection of the Human Bcl2 Protein: Sequence Requirements for Inhibition of Apoptosis

1996 • 126 citations

Microtubule-damaging drugs triggered bcl2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of bcl2 protein.

1998 • 81 citations

Activation of the Jak2-Stat5 Signaling Pathway in Nb2 Lymphoma Cells by an Anti-apoptotic Agent, Aurintricarboxylic Acid

1998 • 79 citations

Differential Involvement of MEK Kinase 1 (MEKK1) in the Induction of Apoptosis in Response to Microtubule-targeted Drugsversus DNA Damaging Agents

1999 • 71 citations

Extracellular Signal-Regulated Kinase (ERK) Activity Is Required for TPA-Mediated Inhibition of Drug-Induced Apoptosis

1998 • 63 citations

A Neuroprotective Compound, Aurin Tricarboxylic Acid, Stimulates the Tyrosine Phosphorylation Cascade in PC12 Cells

1995 • 56 citations

Evolutionary Conservation of Function Among Mammalian, Avian, and Viral Homologs of the Bcl-2 Oncoprotein

1994 • 43 citations

Calphostin C synergistically induces apoptosis with VP-16 in lymphoma cells which express abundant phosphorylated Bcl-2 protein

1997 • 16 citations