A phase I trial of solubilized DR2:MBP ^84-102 (AG284) in multiple sclerosis

Rating neurologic impairment in multiple sclerosis

1983 • 14,011 citations

New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

1983 • 7,404 citations

Defining the clinical course of multiple sclerosis

1996 • 3,606 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

HLA and Disease Associations

1985 • 893 citations

HLA class II-associated genetic susceptibility in multiple sclerosis: A critical evaluation

1991 • 487 citations

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

1987 • 391 citations

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

1990 • 342 citations

Myelin basic protein‐specific T lymphocyte lines from MS patients and healthy individuals

1990 • 332 citations

Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors.

1990 • 307 citations

Upper extremity function in multiple sclerosis: improving assessment sensitivity with box-and-block and nine-hole peg tests.

1988 • 264 citations

Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients.

1993 • 196 citations

A sensitive ELISPOT assay to detect low-frequency human T lymphocytes

1997 • 170 citations

Spontaneous Regression of Primary Autoreactivity during Chronic Progression of Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

1999 • 155 citations

HL‐A Antigens and Multiple Sclerosis

1972 • 124 citations

Specific tolerance to an acetylcholine receptor epitope induced in vitro in myasthenia gravis CD4+ lymphocytes by soluble major histocompatibility complex class II-peptide complexes.

1994 • 77 citations

Predominant and stable T cell responses to regions of myelin basic protein can be detected in individual patients with multiple sclerosis

1993 • 66 citations

Registration of images from sequential MR studies of the brain

1994 • 59 citations

The Association of HLA Antigens A3, B7, and DW2 with 330 Multiple Sclerosis Patients in the United States

1977 • 45 citations

Induction of tolerance in experimental autoimmune myasthenia gravis with solubilized MHC class II: Acetylcholine receptor peptide complexes

1995 • 42 citations

pH dependent binding of high and low affinity myelin basic protein peptides to purified HLA-DR2

1995 • 9 citations

Pathogenesis of Multiple Sclerosis: Relationship to Therapeutic Strategies

1996 • 8 citations

Preclinical and Pharmacological Studies of AG284, a Soluble HLA‐DR2:Myelin Basic Protein Peptide Complex for the Treatment of Multiple Sclerosis

1998 • 7 citations