Glucocorticoid Receptor β: View I

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS

1985 • 1,911 citations

Primary structure and expression of a functional human glucocorticoid receptor cDNA

1985 • 1,851 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Functional domains of the human glucocorticoid receptor

1986 • 933 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1988 • 705 citations

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

1993 • 652 citations

Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans.

1995 • 636 citations

Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation

1988 • 600 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

The Human Glucocorticoid Receptor β Isoform

1996 • 553 citations

The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain

1988 • 522 citations

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor

1987 • 512 citations

Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement

1987 • 428 citations

Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor β

1997 • 413 citations

The genomic structure of the human glucocorticoid receptor.

1991 • 397 citations

Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance.

1991 • 373 citations

Intracellular Receptor Concentration Limits Glucocorticoid-Dependent Enhancer Activity*

1987 • 363 citations

Nuclear Integration of Glucocorticoid Receptor and Nuclear Factor-κB Signaling by CREB-binding Protein and Steroid Receptor Coactivator-1

1998 • 307 citations

Syndromes of Glucocorticoid Resistance

1993 • 237 citations

Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene.

1993 • 224 citations

The steroid receptor superfamily: mechanisms of diversity

1991 • 202 citations

Expression and Subcellular Distribution of the β-Isoform of the Human Glucocorticoid Receptor*

1997 • 193 citations

Structural determinants of DNA-binding specificity by steroid receptors.

1995 • 190 citations

The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): tissue levels, mechanism of action, and potential physiologic role.

1996 • 182 citations

Glucocorticoid hormone resistance during primate evolution: receptor-mediated mechanisms.

1982 • 178 citations

Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation.

1996 • 169 citations

Localization of the 90-kDa heat shock protein-binding site within the hormone-binding domain of the glucocorticoid receptor by peptide competition

1991 • 165 citations

Glucocorticoid Resistance in Asthma

1995 • 157 citations

The Non-Ligand Binding β-Isoform of the Human Glucocorticoid Receptor (hGRβ): Tissue Levels, Mechanism of Action, and Potential Physiologic Role

1996 • 146 citations

Evidence That the β-Isoform of the Human Glucocorticoid Receptor Does Not Act as a Physiologically Significant Repressor

1997 • 141 citations

Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene

1993 • 132 citations

Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions.

1994 • 121 citations

Imbalanced Expression of the Glucocorticoid Receptor Isoforms in Cultured Lymphocytes from a Patient with Systemic Glucocorticoid Resistance and Chronic Lymphocytic Leukemia

1999 • 118 citations

Regulation Of Gene Expression By Glucocorticoids

1989 • 110 citations

Differential Hormone-Dependent Transcriptional Activation and -Repression by Naturally Occurring Human Glucocorticoid Receptor Variants

1997 • 108 citations

Steroid resistance in asthma

1995 • 108 citations

Absence of Glucocorticoid Receptor-β in Mice

1997 • 101 citations

Expression and Subcellular Distribution of the -Isoform of the Human Glucocorticoid Receptor

1997 • 100 citations

Delineation of a small region within the majortransactivation domain of the human glucocorticoid receptor that mediatestransactivation of gene expression.

1994 • 98 citations

Glucocorticoid-resistant asthma: pathogenesis and clinical implications for management

1997 • 97 citations

Expression of Glucocorticoid Receptor Gene Isoforms in Corticotropin-Secreting Tumors¹

1997 • 94 citations

Response to glucocorticoid treatment in rheumatoid arthritis: in vitro cell mediated immune assay predicts in vivo responses.

1991 • 92 citations

Down-regulation of glucocorticoid receptors in mouse lymphoma cell variants.

1984 • 87 citations

Structural determinants of DNA-binding specificity by steroid receptors

1995 • 78 citations

Correlation between glucocorticoid receptor and cytolytic response of murine lymphoid cell lines.

1979 • 76 citations

Clinical pattern of corticosteroid dependent Crohnʼs disease

1998 • 73 citations

Cellular receptor levels and glucocorticoid responsiveness of lymphoma cells

1984 • 72 citations

Regulation of Glucocorticoid Receptor Function through Assembly of a Receptor‐Heat Shock Protein Complex^a

1993 • 61 citations

Expression of Glucocorticoid Receptor Gene Isoforms in Corticotropin-Secreting Tumors

1997 • 60 citations

A conserved carboxy-terminal subdomain is important for ligand interpretation and transactivation by nuclear receptors.

1994 • 58 citations

Steroid Hormone Resistance

1986 • 55 citations

Inhibition of mineralocorticoid activity by the β-isoform of the human glucocorticoid receptor

1997 • 51 citations

Endogenous blockade of 1,25-dihydroxyvitamin D-receptor binding in New World primate cells.

1991 • 49 citations

Regulation of the human interleukin-2 gene by the α and β isoforms of the glucocorticoid receptor1This manuscript is dedicated to Prof. Dr F.A. Leidenberger on the occasion of his 60th birthday.1

1997 • 49 citations

Differential Hormone-Dependent Transcriptional Activation and -Repression by Naturally Occurring Human Glucocorticoid Receptor Variants

1997 • 48 citations

Genetic variation of the glucocorticoid receptor from a steroid-resistant primate

1991 • 47 citations

Uterine Estrogen and Progesterone Receptors in an Estrogen- and Progesterone-“Resistant” Primate*

1984 • 46 citations

Determinants of high-affinity DNA binding by the glucocorticoid receptor: evaluation of receptor domains outside the DNA-binding domain

1992 • 44 citations

Hormone binding domain of human glucocorticoid receptor. Enhancement of transactivation function by substitution mutants M565R and A573Q.

1994 • 38 citations

Decreased corticosensitivity in quiescent Crohn's disease: an ex vivo study using whole blood cell cultures.

1999 • 33 citations

Low level of glucocorticoid receptor messenger ribonucleic acid in pituitary adenomas manifesting Cushing's disease with resistance to a high dose‐dexamethasone suppression test

1998 • 32 citations

A conserved carboxy-terminal subdomain is important for ligand interpretation and transactivation by nuclear receptors

1994 • 24 citations