Structural determinants of DNA-binding specificity by steroid receptors.

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.

1985 • 2,450 citations

Primary structure and expression of a functional human glucocorticoid receptor cDNA

1985 • 1,851 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

1992 • 966 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

Determinants of target gene specificity for steroid/thyroid hormone receptors

1989 • 954 citations

Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene

1987 • 760 citations

The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements

1993 • 745 citations

The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors.

1986 • 733 citations

Steroid Hormone Receptors: Interaction with Deoxyribonucleic Acid and Transcription Factors*

1993 • 724 citations

The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements

1988 • 679 citations

Evolution of the nuclear receptor gene superfamily.

1992 • 662 citations

Solution Structure of the Glucocorticoid Receptor DNA-Binding Domain

1990 • 609 citations

The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors

1991 • 603 citations

Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation

1988 • 600 citations

Retinoic acid and thyroid hormone induce gene expression through a common responsive element

1988 • 586 citations

Identification of the DNA Binding Site for NGFI-B by Genetic Selection in Yeast

1991 • 566 citations

Localisation of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor.

1986 • 533 citations

The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain

1988 • 522 citations

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor

1987 • 512 citations

Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element

1989 • 507 citations

H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes.

1992 • 480 citations

Solution structure of the DMA-binding domain of the oestrogen receptor

1990 • 458 citations

RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors.

1992 • 446 citations

A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor

1988 • 439 citations

The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction.

1986 • 406 citations

Determinants for selective RAR and TR recognition of direct repeat HREs.

1993 • 403 citations

The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction.

1993 • 397 citations

Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.

1992 • 389 citations

Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers.

1993 • 369 citations

Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product

1985 • 368 citations

A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression.

1987 • 360 citations

Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptor

1989 • 358 citations

Oestrogen and glucocorticoid responsive elements are closely related but distinct

1987 • 353 citations

Characterization of response elements for androgens, glucocorticoids and progestins in mouse mammary tumour virus

1988 • 347 citations

Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA fragment whose transcription is regulated by glucocorticoids in vivo.

1981 • 341 citations

Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3.

1992 • 325 citations

Participation of Non-Zinc Finger Residues in DNA Binding by Two Nuclear Orphan Receptors

1992 • 323 citations

DNA regulatory elements for steroid hormones

1989 • 305 citations

Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor.

1987 • 299 citations

Structure of the Retinoid X Receptor α DNA Binding Domain: a Helix Required for Homodimeric DNA Binding

1993 • 296 citations

The estrogen-responsive element as an inducible enhancer: DNA sequence requirements and conversion to a glucocorticoid-responsive element.

1987 • 268 citations

A consensus DNA-binding site for the androgen receptor.

1992 • 267 citations

The N-terminal DNA-binding ‘zinc finger’ of the oestrogen and glucocorticoid receptors determines target gene specificity.

1988 • 265 citations

Sequence homologies in the region preceding the transcription initiation site of the liver estrogen-responsive vitellogenin and apo-VLDLII genes

1984 • 261 citations

Gene Regulation by Steroid Hormones

1990 • 255 citations

A germline mutation in the androgen receptor gene in two brothers with breast cancer and Reifenstein syndrome

1992 • 251 citations

Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities.

1989 • 240 citations

Interaction of the glucocorticoid receptor DNA-binding domain with DNA as a dimer is mediated by a short segment of five amino acids.

1991 • 225 citations

Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements.

1994 • 210 citations

Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptors.

1993 • 207 citations

Structural Determinants of a Glucocorticoid Receptor Recognition Element

1990 • 201 citations

Specific binding of estrogen receptor to the estrogen response element.

1989 • 199 citations

Effect of replacement of “zinc finger” zinc on estrogen receptor DNA interactions.

1992 • 197 citations

A novel DNA-binding motif abuts the zinc finger domain of insect nuclear hormone receptor FTZ-F1 and mouse embryonal long terminal repeat-binding protein.

1992 • 191 citations

Characterization of the purified activated glucocorticoid receptor from rat liver cytosol.

1984 • 186 citations

Domains of the Glucocorticoid Receptor Involved in Specific and Nonspecific Deoxyribonucleic Acid Binding, Hormone Activation, and Transcriptional Enhancement

1987 • 174 citations

A consensus DNA-binding site for the androgen receptor

1992 • 143 citations

Androgen receptor gene mutation in male breast cancer

1993 • 139 citations

Androgen regulation by the long terminal repeat of mouse mammary tumor virus.

1986 • 138 citations

Defining a minimal estrogen receptor DNA binding domain

1993 • 124 citations

Hormone- and DNA-binding mechanism of the recombinant human estrogen receptor

1993 • 119 citations

The constitution of a progesterone response element.

1993 • 118 citations

Molecular Model of the Interaction Between the Glucocorticoid Receptor and the Regulatory Elements of Inducible Genes

1986 • 117 citations

Nonbiased identification of DNA sequences that bind thyroid hormone receptor alpha 1 with high affinity.

1993 • 109 citations

Retinoic acid receptors and cellular retinoid binding proteins: complex interplay in retinoid signaling

1994 • 109 citations

DNA recognition by the oestrogen receptor: from solution to the crystal

1993 • 108 citations

Mutations of androgen receptor gene in androgen insensitivity syndromes

1993 • 92 citations

Contacts between steroid hormone receptors and thymines in DNA: an interference method.

1990 • 90 citations

Protein-protein contacts in the glucocorticoid receptor homodimer influence its DNA binding properties.

1990 • 88 citations

DNA sequences that act as high affinity targets for the vitamin D3 receptor in the absence of the retinoid X receptor.

1994 • 85 citations

Cooperativity and specificity in the interactions between DNA and the glucocorticoid receptor DNA binding domain

1990 • 83 citations

Efficient Binding of Glucocorticoid Receptor to Its Responsive Element Requires a Dimer and DNA Flanking Sequences

1990 • 79 citations

Thyroid hormone receptor functions as monomeric ligand-induced transcription factor on octameric half-sites. Consequences also for dimerization.

1994 • 77 citations

Ordered binding of retinoic acid and retinoid-X receptors to asymmetric response elements involves determinants adjacent to the DNA-binding domain.

1994 • 72 citations

Defining the sequence recognized with BmFTZ-F1, a sequence specific DNA binding factor in the silkworm,Bombyx mori, as revealed by direct sequencing of bound oligonucleotides and gel mobility shift competition analysis

1991 • 66 citations

DNA binding analysis of glucocorticoid receptor specificity mutants

1992 • 65 citations

The constitution of a progesterone response element

1993 • 65 citations

A comparison of ¹⁵N NMR relaxation measurements with a molecular dynamics simulation: Backbone dynamics of the glucocorticoid receptor DNA‐binding domain

1993 • 54 citations

DNA binding specificity of mutant glucocorticoid receptor DNA-binding domains.

1991 • 54 citations

The solution structure of the human retinoic acid receptor-β DNA-binding domain

1993 • 53 citations

Analysis of androgen receptor-DNA interactions with receptor proteins produced in insect cells

1994 • 49 citations

Backbone dynamics of the glucocorticoid receptor DNA-binding domain

1992 • 48 citations

Cadmium-113 NMR studies of the DNA binding domain of the mammalian glucocorticoid receptor

1990 • 47 citations

Effects of Zinc and Other Divalent Metals on Deoxyribonucleic Acid Binding and Hormone-Binding Activity of Human al Thyroid Hormone Receptor Expressed inEscherichia coli*

1991 • 42 citations

Determinants for DNA-binding site recognition by the glucocorticoid receptor.

1992 • 37 citations

Half-site arrangement of hybrid glucocorticoid and thyroid hormone response elements specifies thyroid hormone receptor complex binding to DNA and transcriptional activity.

1994 • 36 citations

Differential impact of flanking sequences on estradiol- vs 4-hydroxytamoxifen-liganded estrogen receptor binding to estrogen responsive element DNA

1993 • 35 citations

Thermodynamics of sequence-specific glucocorticoid receptor-DNA interactions

1994 • 30 citations

A new mutation within the deoxyribonucleic acid-binding domain of the androgen receptor gene in a family with complete androgen insensitivity syndrome

1993 • 29 citations

Zinc coordination scheme for the C-terminal zinc binding site of nuclear hormone receptors

1992 • 17 citations

Zic Finger Mutations that Alter Domain Interactions in the Glucocorticoid Receptor

1993 • 14 citations

Modulation of DNA‐binding specificity within the nuclear receptor family by substitutions at a single amino acid position

1995 • 13 citations

Structural Analysis of the Glucocorticoid Receptor Protein

1989 • 5 citations

Structural Analysis of the Glucocorticoid Receptor Protein

1991 • 1 citations