DNA Fiber Fluorescence In Situ Hybridization Analysis of Immunoglobulin Class Switching in B-Cell Neoplasia: Aberrant CH Gene Rearrangements in Follicle Center-Cell Lymphoma

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing γ, ε and α genes

1982 • 421 citations

Human Immunoglobulin Heavy Chain Genes Map to a Region of Translocations in Malignant B Lymphocytes

1982 • 351 citations

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

1986 • 344 citations

Hairy cell leukemia: a tumor of pre-plasma cells

1985 • 329 citations

Clonal evolution of a follicular lymphoma: evidence for antigen selection.

1992 • 255 citations

Circular DNA is excised by immunoglobulin class switch recombination

1990 • 244 citations

Switch circular DNA formed in cytokine-treated mouse splenocytes: Evidence for intramolecular DNA deletion in immunoglobulin class switching

1990 • 240 citations

Circular DNA is a product of the immunoglobulin class switch rearrangement

1990 • 202 citations

Direct visualization of dispersed 11q13 chromosomal translocations in mantle cell lymphoma by multicolor DNA fiber fluorescence in situ hybridization

1996 • 201 citations

Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic mutations like the physiologic cells of the follicle mantle

1994 • 187 citations

Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection.

1992 • 167 citations

High-resolution DNA Fiber-FISH for genomic DNA mapping and colour bar-coding of large genes

1995 • 137 citations

Complete physical map of the human immunoglobulin heavy chain constant region gene complex.

1989 • 109 citations

Cell markers in hairy cell leukemia studied in cells from 51 patients

1982 • 106 citations

Intermediate lymphocytic lymphoma: clinical and pathologic features of a recently characterized subtype of non-Hodgkin's lymphoma.

1993 • 99 citations

Evolutionary approach to the question of immunoglobulin heavy chain switching: evidence from cloned human and mouse genes.

1980 • 97 citations

Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts.

1986 • 95 citations

Quantitation of immunoglobulin mu-gamma 1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method.

1992 • 80 citations

Deletional switch recombination occurs in interleukin-4-induced isotype switching to IgE expression by human B cells.

1991 • 74 citations

Proliferation and cytogenetic analysis of hairy cell leukemia upon stimulation via the CD40 antigen

1994 • 67 citations

Direct evidence that γ1 and γ3 switching in human B cells is interleukin-10 dependent

1996 • 62 citations

IgD class switching: Identification of a novel recombination site in neoplastic and normal B cells

1995 • 55 citations

Isotype switching in human B lymphocyte malignancies occurs by DNA deletion: evidence for nonspecific switch recombination.

1987 • 46 citations

Hairy cell leukemia preferentially expresses the IgG3-subclass

1990 • 42 citations

Transcription of unrearranged Ig H chain genes in human B cell malignancies. Biased expression of genes encoded within the first duplication unit of the Ig H chain locus.

1992 • 41 citations

Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line.

1984 • 39 citations

Duplications and deletions of the human IGHC locus: evolutionary implications

1996 • 30 citations

Immunoglobulin gene rearrangements and deletions in human Epstein-Barr virus-transformed cell lines producing different IgG and IgA subclasses.

1985 • 25 citations

Variability of the immunoglobulin heavy chain constant region locus: a population study

1995 • 25 citations

New type of t(14; 18) in a non‐Hodgkin's lymphoma provides insight in molecular events in early B‐cell differentiation

1995 • 23 citations

Allelic inclusion in the pre-B-cell line 18-81.

1984 • 23 citations

A submicroscopic interstitial deletion of chromosome 14 frequently occurs adjacent to the t(14;18) translocation breakpoint in human follicular lymphoma

1993 • 20 citations

Class switch recombination of the immunoglobulin heavy chain gene frequently occurs in B-cell lymphomas associated with rearrangement of the BCL2 gene.

1995 • 19 citations

Immunoglobulin JH, C mu, and C gamma gene rearrangements in human B lymphocytes clonally transformed by Epstein-Barr virus.

1985 • 19 citations

Evidence for a human IgG1 class switch program

1993 • 19 citations

Abnormally activated T lymphocytes in the spleen of patients with hairy-cell leukemia.

1994 • 17 citations

Physical linkage of a variable region segment and the joining region segment of the human immunoglobulin heavy chain locus

1988 • 16 citations

Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic mutations like the physiologic cells of the follicle mantle

1994 • 12 citations