The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

A new DNA sequence assembly program

1995 • 969 citations

DNA polymerase fidelity and the polymerase chain reaction.

1991 • 441 citations

Somatic Hypermutation of Immunoglobulin Genes Is Linked to Transcription Initiation

1996 • 424 citations

The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement

1994 • 415 citations

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1994 • 382 citations

Hot Spot Focusing of Somatic Hypermutation in MSH2-Deficient Mice Suggests Two Stages of Mutational Targeting

1998 • 352 citations

The ends of the affair: capping and polyadenylation.

2000 • 340 citations

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.

1990 • 318 citations

Origin of Antibody Variation

1966 • 314 citations

Coupling of Transcription with Alternative Splicing

1999 • 311 citations

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

1993 • 271 citations

Somatic Hypermutation in the Heavy Chain Locus Correlates with Transcription

1998 • 265 citations

Cell-cycle-regulated DNA double-strand breaks in somatic hypermutation of immunoglobulin genes

2000 • 264 citations

TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line

1998 • 255 citations

Somatic hypermutation

1995 • 248 citations

RNA polymerase II elongation through chromatin

2000 • 244 citations

Targeting of non-lg sequences in place of the V segment by somatic hyper mutation

1995 • 223 citations

DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

2000 • 189 citations

Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes.

1997 • 180 citations

Both DNA strands of antibody genes are hypermutation targets

1998 • 163 citations

Mismatch Repair Co-opted by Hypermutation

1998 • 159 citations

The Transcriptional Promoter Regulates Hypermutation of the Antibody Heavy Chain Locus

1997 • 142 citations

Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice

1997 • 133 citations

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3′ of C kappa and occurs on passenger transgenes.

1991 • 132 citations

Distribution of Mutations around Rearranged Heavy-Chain Antibody Variable-Region Genes

1990 • 129 citations

Cells strongly expressing Igκ transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers

1997 • 109 citations

Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes.

1993 • 108 citations

The molecular basis of somatic hypermutation of immunoglobulin genes

1996 • 100 citations

Rearrangement/hypermutation/gene conversion: when, where and why?

1996 • 100 citations

Evolution of somatic hypermutation and gene conversion in adaptive immunity

1998 • 90 citations

The 5′ boundary of somatic hypermutation in a Vχ gene is in the leader intron

1994 • 86 citations

Position of the rearranged V kappa and its 5' flanking sequences determines the location of somatic mutations in the J kappa locus.

1991 • 74 citations

Somatic hypermutation and the three R's: repair, replication and recombination

1999 • 72 citations

Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions.

1994 • 69 citations

Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes

1994 • 69 citations

Somatic hypermutation in 5′ flanking regions of heavy chain antibody variable regions

1993 • 69 citations

Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation

1996 • 63 citations

Somatic mutation in constant regions of mouse lambda 1 light chains.

1991 • 55 citations

The 5′ hypermutation boundary of x chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription

1997 • 48 citations

Maturation of the Immune Response

1996 • 40 citations

Enhanced Evolvability in Immunoglobulin V Genes Under Somatic Hypermutation

1999 • 39 citations

Mechanism of antigen‐driven somatic hypermutation of rearranged immunoglobulin V(D)J genes in the mouse

1997 • 32 citations

Transcription, β–like DNA polymerases and hypermutation

2001 • 18 citations

The Role of Promoter-Intron Interactions in Directing Hypermutation

1998 • 10 citations

Strand Breaks in Immunoglobulin Gene Hypermutation^a

1997 • 8 citations