Cyclin-Dependent Kinases and P53 Pathways Are Activated Independently and Mediate Bax Activation in Neurons after DNA Damage

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Pathobiology of ischaemic stroke: an integrated view

1999 • 3,776 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

Role of NF-κB in p53-mediated programmed cell death

2000 • 730 citations

Role for the p53 homologue p73 in E2F-1-induced apoptosis

2000 • 700 citations

Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain

1998 • 537 citations

An Anti-Apoptotic Role for the p53 Family Member, p73, During Developmental Neuron Death

2000 • 461 citations

Aberrant Expression of Mitotic Cdc2/Cyclin B1 Kinase in Degenerating Neurons of Alzheimer’s Disease Brain

1997 • 444 citations

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

1997 • 417 citations

Phosphorylation of c-Jun Is Necessary for Apoptosis Induced by Survival Signal Withdrawal in Cerebellar Granule Neurons

1998 • 365 citations

Retinoblastoma protein partners

2001 • 348 citations

Bax Involvement in p53-Mediated Neuronal Cell Death

1998 • 337 citations

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

1995 • 334 citations

Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system.

1996 • 325 citations

Attenuation of p53 Expression Protects against Focal Ischemic Damage in Transgenic Mice

1994 • 317 citations

BAX Translocation Is a Critical Event in Neuronal Apoptosis: Regulation by Neuroprotectants, BCL-2, and Caspases

1999 • 314 citations

Early Detection of DNA Strand Breaks in the Brain After Transient Focal Ischemia: Implications for the Role of DNA Damage in Apoptosis and Neuronal Cell Death

1997 • 312 citations

Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity.

1996 • 301 citations

Role of the Jun Kinase Pathway in the Regulation of c-Jun Expression and Apoptosis in Sympathetic Neurons

1998 • 284 citations

Cyclin-dependent kinases as a therapeutic target for stroke

2000 • 276 citations

G1/S Cell Cycle Blockers and Inhibitors of Cyclin-Dependent Kinases Suppress Camptothecin-Induced Neuronal Apoptosis

1997 • 275 citations

Cyclin Dependent Kinase Inhibitors and Dominant Negative Cyclin Dependent Kinase 4 and 6 Promote Survival of NGF-Deprived Sympathetic Neurons

1997 • 270 citations

Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle.

1998 • 270 citations

Cytarabine and neurologic toxicity.

1991 • 264 citations

Cyclin-dependent Kinases Participate in Death of Neurons Evoked by DNA-damaging Agents

1998 • 264 citations

Inhibitors of Cyclin-dependent Kinases Promote Survival of Post-mitotic Neuronally Differentiated PC12 Cells and Sympathetic Neurons

1996 • 252 citations

Evidence for p53-Mediated Modulation of Neuronal Viability

1996 • 247 citations

Multiple Pathways of Neuronal Death Induced by DNA-Damaging Agents, NGF Deprivation, and Oxidative Stress

1998 • 243 citations

Involvement of Cell Cycle Elements, Cyclin-dependent Kinases, pRb, and E2F·DP, in B-amyloid-induced Neuronal Death

1999 • 242 citations

E2F1 Mediates Death of B-amyloid-treated Cortical Neurons in a Manner Independent of p53 and Dependent on Bax and Caspase 3

2000 • 203 citations

Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support

1996 • 201 citations

Caspase-Dependent and -Independent Death of Camptothecin-Treated Embryonic Cortical Neurons

1999 • 200 citations

Apoptosis in neurodegenerative disorders

1997 • 171 citations

E2F-1:DP-1 Induces p53 and Overrides Survival Factors To Trigger Apoptosis

1995 • 167 citations

Involvement of Retinoblastoma Family Members and E2F/DP Complexes in the Death of Neurons Evoked by DNA Damage

2000 • 151 citations

Ras Regulates Sympathetic Neuron Survival by Suppressing the p53-Mediated Cell Death Pathway

1999 • 150 citations

Cerebellar degeneration caused by high‐dose cytosine arabinoside: A clinicopathological study

1983 • 147 citations

Apoptosis Decision Cascades and Neuronal Degeneration in Alzheimer’s Disease

1998 • 146 citations

Induction and Modulation of Cerebellar Granule Neuron Death by E2F-1

2000 • 143 citations

Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death?

1999 • 141 citations

Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G₁

1996 • 139 citations

Cytosine arabinoside kills postmitotic neurons in a fashion resembling trophic factor deprivation: evidence that a deoxycytidine-dependent process may be required for nerve growth factor signal transduction

1990 • 132 citations

Involvement of p53 in DNA Strand Break‐induced Apoptosis in Postmitotic CNS Neurons

1996 • 119 citations

Contribution of p53-Dependent Caspase Activation to Neuronal Cell Death Declines with Neuronal Maturation

1999 • 111 citations

p53 involves cytosine arabinoside-induced apoptosis in cultured cerebellar granule neurons

1996 • 107 citations

The Transcription Factor E2F1 Modulates Apoptosis of Neurons

2000 • 105 citations

Cytosine arabinoside kills postmitotic neurons: evidence that deoxycytidine may have a role in neuronal survival that is independent of DNA synthesis

1989 • 96 citations

Involvement of Caspase 3 in Apoptotic Death of Cortical Neurons Evoked by DNA Damage

2000 • 91 citations

Placement of the BCL2 Family Member BAX in the Death Pathway of Sympathetic Neurons Activated by Trophic Factor Deprivation

1998 • 82 citations

Induction of Cyclin B and H1 Kinase Activity in Apoptotic PC12 Cells

1995 • 64 citations

p53 phosphorylation and association with murine double minute 2, c-Jun NH2-terminal kinase, p14ARF, and p300/CBP during the cell cycle and after exposure to ultraviolet irradiation.

2000 • 64 citations

Apoptosis is induced in post-mitotic rat sympathetic neurons by arabinosides and topoisomerase II inhibitors in the presence of NGF

1994 • 60 citations

Decreased brain infarct following focal ischemia in mice lacking the transcription factor E2F1

1999 • 59 citations

Filamentous degeneration of neurons. A possible feature of cytosine arabinoside neurotoxicity

1993 • 40 citations

Etoposide induces programmed death in neurons cultured from the fetal rat central nervous system

1994 • 37 citations

Rb Protein Down-regulates the Stress-activated Signals through Inhibiting c-Jun N-terminal Kinase/Stress-activated Protein Kinase

2000 • 36 citations

Functional interaction between retinoblastoma protein and stress-activated protein kinase in multiple myeloma cells.

1999 • 27 citations

The Retinoblastoma Gene Product (Rb) Induces Binding of a Conformationally Inactive Nuclear Factor-κB

1996 • 17 citations

MR of cis-platinum-induced optic neuritis.

1994 • 8 citations