Estrogen action and cytoplasmic signaling cascades. Part I: membrane-associated signaling complexes

The Protective Effects of Estrogen on the Cardiovascular System

1999 • 3,003 citations

Mechanisms of Estrogen Action

2001 • 1,945 citations

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

1993 • 1,836 citations

Generation and reproductive phenotypes of mice lacking estrogen receptor β

1998 • 1,680 citations

Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription

2000 • 1,658 citations

Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

2000 • 1,411 citations

Estrogen Actions in the Central Nervous System¹

1999 • 1,381 citations

The Multifaceted Mechanisms of Estradiol and Estrogen Receptor Signaling

2001 • 1,179 citations

Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ERα and ERβ Expressed in Chinese Hamster Ovary Cells

1999 • 1,046 citations

Dynamic activation of endothelial nitric oxide synthase by Hsp90

1998 • 1,016 citations

Gene Dosage–Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300

1998 • 984 citations

Phosphatidylinositol 3-Kinase/AKT-mediated Activation of Estrogen Receptor α

2001 • 934 citations

Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen

1999 • 895 citations

Estrogen Action Via the G Protein-Coupled Receptor, GPR30: Stimulation of Adenylyl Cyclase and cAMP-Mediated Attenuation of the Epidermal Growth Factor Receptor-to-MAPK Signaling Axis

2002 • 840 citations

Potocytosis: Sequestration and Transport of Small Molecules by Caveolae

1992 • 751 citations

Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells

1977 • 686 citations

Partial Hormone Resistance in Mice with Disruption of the Steroid Receptor Coactivator-1 (SRC-1) Gene

1998 • 685 citations

Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription.

1994 • 667 citations

Rapid actions of plasma membrane estrogen receptors

2001 • 649 citations

Estrogen Actions in the Central Nervous System

1999 • 641 citations

Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor

1996 • 638 citations

Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor

1998 • 618 citations

Postnatal Sex Reversal of the Ovaries in Mice Lacking Estrogen Receptors α and β

1999 • 583 citations

Membrane Estrogen Receptor Engagement Activates Endothelial Nitric Oxide Synthase via the PI3-Kinase–Akt Pathway in Human Endothelial Cells

2000 • 558 citations

Membrane estrogen receptors identified by multiple antibody labeling and impeded‐ligand binding

1995 • 532 citations

Coregulator Codes of Transcriptional Regulation by Nuclear Receptors

2001 • 507 citations

Rapid Membrane Effects of Steroids in Neuroblastoma Cells: Effects of Estrogen on Mitogen Activated Protein Kinase Signalling Cascade and c-fos Immediate Early Gene Transcription

1997 • 478 citations

Estrogen-Induced Activation of Mitogen-Activated Protein Kinase in Cerebral Cortical Explants: Convergence of Estrogen and Neurotrophin Signaling Pathways

1999 • 474 citations

Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.

1994 • 460 citations

Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1

2000 • 405 citations

Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling

2000 • 382 citations

ERs Associate with and Regulate the Production of Caveolin: Implications for Signaling and Cellular Actions

2002 • 380 citations

Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ER and ER Expressed in Chinese Hamster Ovary Cells

1999 • 371 citations

The Estrogen Receptor Enhances AP-1 Activity by Two Distinct Mechanisms with Different Requirements for Receptor Transactivation Functions

1999 • 369 citations

Ligand-independent activation of steroid hormone receptors

1998 • 349 citations

17β-Estradiol Potentiates Kainate-Induced Currents via Activation of the cAMP Cascade

1996 • 347 citations

Cross-Talk between Peptide Growth Factor and Estrogen Receptor Signaling Pathways

1998 • 334 citations

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene

1993 • 315 citations

Nongenomic Stimulation of Nitric Oxide Release by Estrogen Is Mediated by Estrogen Receptor α Localized in Caveolae

1999 • 304 citations

Estrogen rapidly induces the phosphorylation of the cAMP response element binding protein in rat brain.

1996 • 283 citations

Plasma Membrane Estrogen Receptors Are Coupled to Endothelial Nitric-oxide Synthase through Gαi

2001 • 279 citations

Non-transcriptional action of oestradiol and progestin triggers DNA synthesis

1999 • 252 citations

Rapid Action of 17β-Estradiol on Kainate-Induced Currents in Hippocampal Neurons Lacking Intracellular Estrogen Receptors*

1999 • 233 citations

Plasma Membrane Estrogen Receptors Signal to Antiapoptosis in Breast Cancer

2000 • 224 citations

Membrane‐Initiated Steroid Actions and theProteins that Mediate Them

1999 • 214 citations

Estrogen Action Via the G Protein-Coupled Receptor, GPR30: Stimulation of Adenylyl Cyclase and cAMP-Mediated Attenuation of the Epidermal Growth Factor Receptor-to-MAPK Signaling Axis

2002 • 201 citations

Modulation of G Protein-Coupled Receptors by an Estrogen Receptor that Activates Protein Kinase A

1997 • 197 citations

Estrogen Stimulates Heat Shock Protein 90 Binding to Endothelial Nitric Oxide Synthase in Human Vascular Endothelial Cells

2000 • 177 citations

Membrane-associated binding sites for estrogen contribute to growth regulation of human breast cancer cells

2001 • 169 citations

Caveolin-1 Potentiates Estrogen Receptor α (ERα) Signaling

1999 • 151 citations

Rapid Membrane Effects of Steroids in Neuroblastoma Cells: Effects of Estrogen on Mitogen Activated Protein Kinase Signalling Cascade and c-fos Immediate Early Gene Transcription

1997 • 143 citations

Estrogenic stimulation of neurite growth in midbrain dopaminergic neurons depends on cAMP/protein kinase A signalling

2000 • 136 citations

Estradiol Signaling via Sequestrable Surface Receptors

2001 • 130 citations

Antibodies to the estrogen receptor‐α modulate rapid prolactin release from rat pituitary tumor cells through plasma membrane estrogen receptors

2000 • 129 citations

Molecular mechanism of a cross‐talk between oestrogen and growth factor signalling pathways

2000 • 124 citations

The Estrogen Receptor Enhances AP-1 Activity by Two Distinct Mechanisms with Different Requirements for Receptor Transactivation Functions

1999 • 105 citations

ERs Associate with and Regulate the Production of Caveolin: Implications for Signaling and Cellular Actions

2002 • 96 citations

Estrogen rapidly induces the phosphorylation of the cAMP response element binding protein in rat brain

1996 • 93 citations

Steroids conjugated to bovine serum albumin as tools to demonstrate specific steroid neuronal membrane binding sites.

1996 • 83 citations

17?-estradiol-BSA conjugates and 17?-estradiol regulate growth plate chondrocytes by common membrane associated mechanisms involving PKC dependent and independent signal transduction

2001 • 82 citations

Nuclear receptors, coactivators and chromatin: new approaches, new insights

2001 • 77 citations

Characterization of membrane estrogen binding proteins from rabbit uterus

1999 • 74 citations

Plasma Membrane Estrogen Receptors Signal to Antiapoptosis in Breast Cancer

2000 • 68 citations

Rapid Action of 17 -Estradiol on Kainate-Induced Currents in Hippocampal Neurons Lacking Intracellular Estrogen Receptors

1999 • 64 citations

An issue of tissues: divining the split personalities of selective estrogen receptor modulators

2000 • 58 citations

Vascular effects of estrogens: arterial protection versus venous thrombotic risk

2001 • 53 citations

G?q/11 and G?? proteins and membrane signaling of calcitriol and estradiol

1999 • 53 citations

ESTROGEN DOWNREGULATES THE NUMBER OF CAVEOLAE AND THE LEVEL OF CAVEOLIN IN UTERINE SMOOTH MUSCLE

2001 • 49 citations

Identification of phosphorylation sites in the mouse oestrogen receptor

1995 • 38 citations

Expression of 112-kDa Estrogen Receptor in Mouse Brain Cortex and Its Autoregulation with Age

1997 • 38 citations

Activation of signal transduction kinases by tamoxifen.

1997 • 36 citations

Episodic Luteinizing-Hormone Release in the Ovariectomized Female Guinea Pig: Rapid Inhibition by Estrogen1

1988 • 28 citations

Gαq11 and Gβγ proteins and membrane signaling of calcitriol and estradiol

1999 • 19 citations

Tamoxifen-induced Ca 2+ mobilization in bladder female transitional carcinoma cells

2001 • 16 citations