Vascular effects of estrogens: arterial protection versus venous thrombotic risk

Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women

1998 • 6,250 citations

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

1997 • 4,422 citations

Menopause and Risk of Cardiovascular Disease

1976 • 1,324 citations

Estrogen and Coronary Heart Disease in Women

1991 • 1,237 citations

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors and

1997 • 1,148 citations

Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen

1999 • 895 citations

Risk of venous thromboembolism in users of hormone replacement therapy

1996 • 827 citations

C-Reactive Protein as a Cardiovascular Risk Factor

1999 • 824 citations

Postmenopausal Hormone Therapy Increases Risk for Venous Thromboembolic Disease: The Heart and Estrogen/progestin Replacement Study

2000 • 716 citations

Effects of Raloxifene on Serum Lipids and Coagulation Factors in Healthy Postmenopausal Women

1998 • 702 citations

Western diet and Western diseases: Some hormonal and biochemical mechanisms and associations

1990 • 691 citations

Effect of Postmenopausal Hormones on Inflammation-Sensitive Proteins

1999 • 679 citations

Risk of hospital admission for idiopathic venous thromboembolism among users of postmenopausal oestrogens

1996 • 606 citations

C-Reactive Protein in the Arterial Intima

2000 • 590 citations

Steroid receptors and their associated proteins.

1993 • 513 citations

Mortality and morbidity in transsexual subjects treated with cross‐sex hormones

1997 • 511 citations

Variable expression of the estrogen receptor in normal and atherosclerotic coronary arteries of premenopausal women.

1994 • 499 citations

Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice

1997 • 499 citations

Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling

2000 • 382 citations

Effects of Oral and Transdermal Estrogen/Progesterone Regimens on Blood Coagulation and Fibrinolysis in Postmenopausal Women

1997 • 353 citations

Hormone replacement therapy and risk of venous thromboembolism: population based case-control study

1997 • 349 citations

The Effects of Hormone Replacement Therapy and Raloxifene on C-Reactive Protein and Homocysteine in Healthy Postmenopausal Women: A Randomized, Controlled Trial1

2000 • 334 citations

Reconstitution of an Endothelial Nitric-oxide Synthase (eNOS), hsp90, and Caveolin-1 Complex in Vitro

2000 • 312 citations

Increased Expression of Estrogen Receptor-β mRNA in Male Blood Vessels After Vascular Injury

1998 • 303 citations

Western diet and Western diseases: Some hormonal and biochemical mechanisms and associations

1990 • 301 citations

Estrogen and coronary heart disease in women

1991 • 273 citations

Estrogen Reduces Myointimal Proliferation After Balloon Injury of Rat Carotid Artery

1996 • 260 citations

Estrogen inhibits the vascular injury response in estrogen receptor β-deficient female mice

1999 • 254 citations

Steroid receptors and their associated proteins

1993 • 231 citations

Expression of an Estrogen Receptor by Human Coronary Artery and Umbilical Vein Endothelial Cells

1996 • 218 citations

Premature Coronary Artery Disease Associated With a Disruptive Mutation in the Estrogen Receptor Gene in a Man

1997 • 205 citations

Estrogen Receptors α and β

2000 • 204 citations

Platelet-Leukocyte Cross Talk in Whole Blood

2000 • 202 citations

Human megakaryocytes and platelets contain the estrogen receptor β and androgen receptor (AR): testosterone regulates AR expression

2000 • 202 citations

Estrogen Stimulates Heat Shock Protein 90 Binding to Endothelial Nitric Oxide Synthase in Human Vascular Endothelial Cells

2000 • 177 citations

Lack of Effect of Raloxifene on Coronary Artery Atherosclerosis of Postmenopausal Monkeys1

1998 • 176 citations

Hormone Replacement Therapy, Prothrombotic Mutations, and the Risk of Incident Nonfatal Myocardial Infarction in Postmenopausal Women

2001 • 172 citations

Long-Term Estrogen Therapy Improves Vascular Function in Male to Female Transsexuals

1997 • 165 citations

Nongenomic, ER-Mediated Activation of Endothelial Nitric Oxide Synthase:

2000 • 155 citations

Hormone Replacement Therapy and the Risk of Hospitalization for Venous Thromboembolism: A Population-based Study in Southern Europe

1998 • 151 citations

Hormone Replacement Therapy and Incidence of Acute Myocardial Infarction

2000 • 150 citations

The Effects of Hormone Replacement Therapy and Raloxifene on C-Reactive Protein and Homocysteine in Healthy Postmenopausal Women: A Randomized, Controlled Trial

2000 • 141 citations

Mechanism of shear-induced prostacyclin production in endothelial cells

1989 • 136 citations

Steroid potentiation of responses to sympathomimetic amines in aortic strips

1969 • 134 citations

Antioxidant activities of estrogens against aqueous and lipophilic radicals; differences between phenol and catechol estrogens

2000 • 134 citations

Raloxifene Acutely Relaxes Rabbit Coronary Arteries In Vitro by an Estrogen Receptor–Dependent and Nitric Oxide–Dependent Mechanism

1999 • 133 citations

Clinically Used Estrogens Differentially Inhibit Human Aortic Smooth Muscle Cell Growth and Mitogen-Activated Protein Kinase Activity

2000 • 108 citations

Estrogen and Tamoxifen Metabolites Protect Smooth Muscle Cell Membrane Phospholipids Against Peroxidation and Inhibit Cell Growth

1999 • 103 citations

Estrogen Stimulates Neuronal Nitric Oxide Synthase Protein Expression in Human Neutrophils

1999 • 98 citations

Risk of Venous Thromboembolism in Users of Hormone Replacement Therapy

1997 • 96 citations

The effect of estrogen replacement therapy on platelet aggregation and adenosine triphosphate release in postmenopausal women.

1993 • 95 citations

Menopause Is Associated With a Significant Increase in Blood Monocyte Number and a Relative Decrease in the Expression of Estrogen Receptors in Human Peripheral Monocytes

1995 • 94 citations

Importance of Estrogen Receptors in Hepatic LDL Receptor Regulation

1997 • 90 citations

Lack of Effect of Raloxifene on Coronary Artery Atherosclerosis of Postmenopausal Monkeys

1998 • 80 citations

Estrogen attenuates the adventitial contribution to neointima formation in injured rat carotid arteries

1999 • 80 citations

Hormone and Nonhormone Therapy for the Maintenance of Postmenopausal Health: The Need for Randomized Controlled Trials of Estrogen and Raloxifene

1998 • 78 citations

Rapid activation of endothelial nitric oxide synthase by estrogen

1999 • 75 citations

Risk of Hospital Admission for Idiopathic Venous Thromboembolism Among Users of Postmenopausal Oestrogens

1997 • 65 citations

Estrogen Inhibits Vascular Smooth Muscle Cell–Dependent Adventitial Fibroblast Migration In Vitro

1999 • 65 citations

Estrogen increases Ca2+efflux from female porcine coronary arterial smooth muscle

1999 • 62 citations

Tamoxifen acutely relaxes coronary arteries by an endothelium-, nitric oxide-, and estrogen receptor-dependent mechanism.

2000 • 55 citations

Selective estrogen receptor modulators (SERMs) in clinical practice

2000 • 55 citations

Oestrogen Synthesis, Oestrogen Metabolism and Functional Oestrogen Receptors in Bovine Aortic Endothelial Cells

2007 • 53 citations

Effects of estradiol on release and disposition of norepinephrine from nerve endings

1980 • 53 citations

Physiological concentration of 17 beta-estradiol inhibits chemotaxis of human monocytes in response to monocyte chemotactic protein 1.

1996 • 41 citations

Relation of fibrinolytic potentiation by estrogen to coagulation pathway activation in postmenopausal women

1999 • 41 citations

Hormone replacement therapy and cardiovascular disease

1999 • 39 citations

Effects of 17β-estradiol and progesterone on migration of human monocytic THP-1 cells stimulated by minimally oxidized low-density lipoprotein in vitro

1997 • 35 citations

Management of Patients at High Risk for Breast Cancer

2002 • 32 citations

Soy Phytoestrogens

2000 • 29 citations

Endothelium-dependent relaxation in response to aggregating platelets in porcine femoral veins and its modulation by diet.

1989 • 29 citations

Atheroprotective effect of estriol and estrone sulfate on human vascular smooth muscle cells

2000 • 29 citations

Venous Thromboembolism [Abridged]

1975 • 28 citations

Modulation of endothelium-derived nitric oxide in canine femoral veins

1996 • 27 citations

Long-Term Effect of 17β-Estradiol and Thrombin on Tissue Factor Pathway Inhibitor Release from HUVEC☆

2000 • 19 citations

Modulation of contractions to and receptors for endothelins in canine veins

1995 • 18 citations

Collaborative Multidisciplinary Workshop Report: Interface of Lipid Metabolism, Atherosclerosis, andChlamydiaInfection

2000 • 11 citations

Tolerability profile of SERMs

1999 • 5 citations

Deleted Work

1955 • 0 citations