Effectiveness of a Human Monoclonal Anti-Endotoxin Antibody (HA-1A) in Gram-Negative Sepsis: Relationship to Endotoxin and Cytokine Levels

APACHE II-A Severity of Disease Classification System

1986 • 12,607 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin

1991 • 1,611 citations

A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock

1987 • 1,434 citations

Gram-negative bacteremia

1980 • 1,341 citations

Septic Shock in Humans

1990 • 1,170 citations

Treatment of Gram-Negative Bacteremia and Shock with Human Antiserum to a MutantEscherichia coli

1982 • 1,062 citations

Increased plasma levels of interleukin-6 in sepsis [see comments]

1989 • 813 citations

Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways

1990 • 796 citations

Tumor Necrosis Factor and Interleuktn-1 in the Serum of Children with Severe Infectious Purpura

1988 • 735 citations

Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group.

1989 • 709 citations

Endotoxemia in Human Septic Shock

1991 • 656 citations

Plasma Endotoxin as a Predictor of Multiple Organ Failure and Death in Systemic Meningococcal Disease

1989 • 564 citations

Functional discrimination between interleukin 6 and interleukin 1

1988 • 443 citations

PREVENTION OF GRAM-NEGATIVE SHOCK AND DEATH IN SURGICAL PATIENTS BY ANTIBODY TO ENDOTOXIN CORE GLYCOLIPID

1985 • 381 citations

Endotoxemia elicits increased circulating beta 2-IFN/IL-6 in man.

1989 • 323 citations

Detection of Endotoxin in the Blood of Patients with Sepsis Due to Gram-Negative Bacteria

1970 • 322 citations

Protection against gram-negative bacteremia and endotoxemia with human monoclonal IgM antibodies.

1985 • 316 citations

Treatment of E. Coli and Klebsiella Bacteremia in Agranulocytic Animals with Antiserum to a UDP-GAL Epimerase-Deficient Mutant

1973 • 216 citations

Limitations of the Usefulness of the Limulus Assay for Endotoxin

1973 • 180 citations

Serial Quantitation of Endotoxemia and Bacteremia During Therapy for Gram-Negative Bacterial Sepsis

1988 • 178 citations

Endotoxin testing in blood.

1987 • 36 citations

Detection of endotoxemia with the Limulus test: Preliminary studies in severely malnourished children

1974 • 23 citations

Clinical evaluation in febrile patients of an optimized endotoxin assay in blood.

1987 • 15 citations

Overview of Gram-Negative Sepsis

1990 • 13 citations

HA-1A

1992 • 11 citations