Insulin alleles and autoimmune regulator (AIRE) gene expression both influence insulin expression in the thymus

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

1984 • 744 citations

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

2005 • 744 citations

Autoimmune Polyendocrine Syndromes

2004 • 650 citations

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

2005 • 540 citations

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

2005 • 417 citations

Gene Dosage–limiting Role ofAirein Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity

2004 • 291 citations

Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR

1993 • 271 citations

A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus

1984 • 205 citations

Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse

2003 • 201 citations

Promiscuous gene expression and central T-cell tolerance: more than meets the eye

2002 • 198 citations

IDDM2-VNTR-encoded Susceptibility to Type 1 Diabetes: Dominant Protection and Parental Transmission of Alleles of the Insulin Gene-linked Minisatellite Locus

1996 • 165 citations

Unusual DNA structure of the diabetes susceptibility locus IDDM2 and its effect on transcription by the insulin promoter factor Pur-1/MAZ

2000 • 108 citations

Insulin Gene Region-Encoded Susceptibility to IDDM Maps Upstream of the Insulin Gene

1995 • 91 citations

Direct analysis of thymic function in children with Down's syndrome

2005 • 37 citations

Insulin gene region-encoded susceptibility to IDDM maps upstream of the insulin gene

1995 • 28 citations