CpG Island Methylation, Microsatellite Instability, and BRAF Mutations and Their Clinical Application in the Treatment of Colon Cancer

Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer

2004 • 10,779 citations

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

2005 • 6,083 citations

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer

2004 • 4,992 citations

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

1998 • 4,047 citations

Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer

2009 • 3,698 citations

Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer

2008 • 3,101 citations

Bevacizumab in Combination With Oxaliplatin-Based Chemotherapy As First-Line Therapy in Metastatic Colorectal Cancer: A Randomized Phase III Study

2008 • 2,832 citations

MAP kinase signalling pathways in cancer

2007 • 2,757 citations

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

2004 • 2,674 citations

Cell-free nucleic acids as biomarkers in cancer patients

2011 • 2,630 citations

CpG island methylator phenotype in colorectal cancer

1999 • 2,476 citations

Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer

2003 • 2,056 citations

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

2010 • 2,043 citations

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

2006 • 1,883 citations

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

2012 • 1,880 citations

Randomized, Phase III Trial of Panitumumab With Infusional Fluorouracil, Leucovorin, and Oxaliplatin (FOLFOX4) Versus FOLFOX4 Alone As First-Line Treatment in Patients With Previously Untreated Metastatic Colorectal Cancer: The PRIME Study

2010 • 1,732 citations

Wild-Type BRAF Is Required for Response to Panitumumab or Cetuximab in Metastatic Colorectal Cancer

2008 • 1,579 citations

Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer

2010 • 1,470 citations

MethyLight: a high-throughput assay to measure DNA methylation

2000 • 1,382 citations

Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study

2007 • 1,357 citations

Classification of colorectal cancer based on correlation of clinical, morphological and molecular features

2006 • 1,327 citations

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

2008 • 1,305 citations

Prognostic Role of KRAS and BRAF in Stage II and III Resected Colon Cancer: Results of the Translational Study on the PETACC-3, EORTC 40993, SAKK 60-00 Trial

2009 • 1,096 citations

Targeting the mitogen-activated protein kinase cascade to treat cancer

2004 • 1,093 citations

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

1993 • 1,076 citations

Randomized Phase III Study of Panitumumab With Fluorouracil, Leucovorin, and Irinotecan (FOLFIRI) Compared With FOLFIRI Alone As Second-Line Treatment in Patients With Metastatic Colorectal Cancer

2010 • 971 citations

Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial

2011 • 923 citations

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

2011 • 904 citations

Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability.

1998 • 855 citations

Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences.

1994 • 807 citations

CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer

2008 • 767 citations

Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours

2001 • 747 citations

Poor Survival Associated with the BRAF V600E Mutation in Microsatellite-Stable Colon Cancers

2005 • 725 citations

BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum

2004 • 716 citations

Accelerated age-related CpG island methylation in ulcerative colitis.

2001 • 624 citations

Value of Mismatch Repair, KRAS, and BRAF Mutations in Predicting Recurrence and Benefits From Chemotherapy in Colorectal Cancer

2011 • 623 citations

Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer

2007 • 549 citations

KRAS and BRAF Mutations in Advanced Colorectal Cancer Are Associated With Poor Prognosis but Do Not Preclude Benefit From Oxaliplatin or Irinotecan: Results From the MRC FOCUS Trial

2009 • 539 citations

DNA Mismatch Repair Status and Colon Cancer Recurrence and Survival in Clinical Trials of 5-Fluorouracil-Based Adjuvant Therapy

2011 • 484 citations

Morphology of sporadic colorectal cancer with DNA replication errors

1998 • 465 citations

EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome

2009 • 460 citations

Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers.

2002 • 437 citations

Irinotecan Fluorouracil Plus Leucovorin Is Not Superior to Fluorouracil Plus Leucovorin Alone As Adjuvant Treatment for Stage III Colon Cancer: Results of CALGB 89803

2007 • 435 citations

CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability

2002 • 371 citations

CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies

2006 • 358 citations

Microsatellite Instability Predicts Improved Response to Adjuvant Therapy With Irinotecan, Fluorouracil, and Leucovorin in Stage III Colon Cancer: Cancer and Leukemia Group B Protocol 89803

2009 • 355 citations

Prognostic and Predictive Roles of High-Degree Microsatellite Instability in Colon Cancer: A National Cancer Institute–National Surgical Adjuvant Breast and Bowel Project Collaborative Study

2007 • 340 citations

Clinical Outcomes Associated with Bevacizumab-Containing Treatment of Metastatic Colorectal Cancer: The BRiTE Observational Cohort Study

2009 • 303 citations

CpG Island Methylator Phenotype-Low (CIMP-Low) in Colorectal Cancer: Possible Associations with Male Sex and KRAS Mutations

2006 • 296 citations

BRAF and KRAS Mutations in Hyperplastic Polyps and Serrated Adenomas of the Colorectum

2004 • 285 citations

BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair.

2003 • 285 citations

Methylation changes in faecal DNA: a marker for colorectal cancer screening?

2004 • 283 citations

PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors.

2010 • 281 citations

Hypermethylator Phenotype in Sporadic Colon Cancer: Study on a Population-Based Series of 582 Cases

2008 • 275 citations

Association of Smoking, CpG Island Methylator Phenotype, and V600E BRAF Mutations in Colon Cancer

2006 • 266 citations

CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer.

2003 • 263 citations

Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands

2002 • 257 citations

Predictive and Prognostic Roles of BRAF Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803

2011 • 253 citations

5-Fluorouracil Adjuvant Chemotherapy Does Not Increase Survival in Patients With CpG Island Methylator Phenotype Colorectal Cancer

2010 • 197 citations

Adverse Prognostic Effect of Methylation in Colorectal Cancer Is Reversed by Microsatellite Instability

2003 • 194 citations

Low-level microsatellite instability in most colorectal carcinomas.

2002 • 191 citations

The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch Syndrome: from bench to bedside

2007 • 188 citations

Association between DNA Methylation and Shortened Survival in Patients with Advanced Colorectal Cancer Treated with 5-Fluorouracil–Based Chemotherapy

2007 • 182 citations

The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status

2010 • 165 citations

KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer

2009 • 148 citations

MRE11 Deficiency Increases Sensitivity to Poly(ADP-ribose) Polymerase Inhibition in Microsatellite Unstable Colorectal Cancers

2011 • 143 citations

Azacytidine and Decitabine Induce Gene-Specific and Non-Random DNA Demethylation in Human Cancer Cell Lines

2011 • 140 citations

Analysis of the Association between CIMP and BRAFV600E in Colorectal Cancer by DNA Methylation Profiling

2009 • 139 citations

Clinicopathological features of CpG island methylator phenotype‐positive colorectal cancer and its adverse prognosis in relation to KRAS/BRAF mutation

2008 • 138 citations

BRAF mutation, CpG island methylator phenotype and microsatellite instability occur more frequently and concordantly in mucinous than non‐mucinous colorectal cancer

2005 • 138 citations

Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer

2005 • 124 citations

CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma

2007 • 122 citations

Distinct CpG island methylation profiles and BRAF mutation status in serrated and adenomatous colorectal polyps

2008 • 120 citations

A Role for Mitogen-activated Protein Kinase in the Spindle Assembly Checkpoint in XTC Cells

1997 • 100 citations

Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features

2010 • 99 citations

Microsatellite instability (MSI) in stage II and III colon cancer treated with 5FU-LV or 5FU-LV and irinotecan (PETACC 3-EORTC 40993-SAKK 60/00 trial)

2009 • 92 citations

Role of BRAF‐V600E in the serrated pathway of colorectal tumourigenesis

2007 • 91 citations

Genetic Variants of Methyl Metabolizing Enzymes and Epigenetic Regulators: Associations with Promoter CpG Island Hypermethylation in Colorectal Cancer

2009 • 86 citations

Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines

2008 • 84 citations

The CpG island methylator phenotype may confer a survival benefit in patients with stage II or III colorectal carcinomas receiving fluoropyrimidine-based adjuvant chemotherapy

2011 • 79 citations

BRAF mutations in colorectal carcinoma suggest two entities of microsatellite‐unstable tumors

2005 • 72 citations

Results of a phase III randomized, double-blind, placebo-controlled, multicenter trial (CORRECT) of regorafenib plus best supportive care (BSC) versus placebo plus BSC in patients (pts) with metastatic colorectal cancer (mCRC) who have progressed after standard therapies.

2012 • 70 citations

CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels

2008 • 61 citations

CpG Island Methylator Phenotype in Colorectal Cancers: Comparison of the New and Classic CpG Island Methylator Phenotype Marker Panels

2008 • 56 citations

A requirement for MAP kinase in the assembly and maintenance of the mitotic spindle

2003 • 51 citations

BRAFV600E Efficient Transformation and Induction of Microsatellite Instability Versus KRASG12V Induction of Senescence Markers in Human Colon Cancer Cells

2009 • 42 citations

Somatic BRAF-V600E Mutations in Familial Colorectal Cancer

2006 • 40 citations

Relative role of methylator and tumor suppressor pathways in ulcerative colitis-associated colon cancer

2011 • 36 citations

Unique patterns of CpG island methylation in inflammatory bowel disease-associated colorectal cancers

2011 • 30 citations

Low expression of γ-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype

2008 • 25 citations

Deleted Work

1955 • 0 citations