CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

1998 • 4,047 citations

CpG island methylator phenotype in colorectal cancer

1999 • 2,476 citations

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

2006 • 1,883 citations

Systematic Review of Microsatellite Instability and Colorectal Cancer Prognosis

2005 • 1,761 citations

MethyLight: a high-throughput assay to measure DNA methylation

2000 • 1,382 citations

Classification of colorectal cancer based on correlation of clinical, morphological and molecular features

2006 • 1,327 citations

CpG island methylator phenotype in cancer

2004 • 1,052 citations

Physical Activity and Survival After Colorectal Cancer Diagnosis

2006 • 827 citations

Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of COX-2

2007 • 727 citations

Poor Survival Associated with the BRAF V600E Mutation in Microsatellite-Stable Colon Cancers

2005 • 725 citations

BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum

2004 • 716 citations

Evaluation of a Large, Population-Based Sample Supports a CpG Island Methylator Phenotype in Colon Cancer

2005 • 571 citations

The Nurses' Health Study: lifestyle and health among women

2005 • 552 citations

Sensitive Sequencing Method for KRAS Mutation Detection by Pyrosequencing

2005 • 492 citations

Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype

2000 • 462 citations

Molecular Classification and Correlates in Colorectal Cancer

2007 • 444 citations

BRAF Mutation Is Frequently Present in Sporadic Colorectal Cancer with Methylated hMLH1, But Not in Hereditary Nonpolyposis Colorectal Cancer

2004 • 404 citations

Precision and Performance Characteristics of Bisulfite Conversion and Real-Time PCR (MethyLight) for Quantitative DNA Methylation Analysis

2006 • 399 citations

CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability

2002 • 371 citations

Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis

2008 • 359 citations

CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies

2006 • 358 citations

Evaluation of Markers for CpG Island Methylator Phenotype (CIMP) in Colorectal Cancer by a Large Population-Based Sample

2007 • 354 citations

BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing

2004 • 344 citations

Prognostic and Predictive Roles of High-Degree Microsatellite Instability in Colon Cancer: A National Cancer Institute–National Surgical Adjuvant Breast and Bowel Project Collaborative Study

2007 • 340 citations

The CpG Island Methylator Phenotype and Chromosomal Instability Are Inversely Correlated in Sporadic Colorectal Cancer

2006 • 303 citations

CpG Island Methylator Phenotype-Low (CIMP-Low) in Colorectal Cancer: Possible Associations with Male Sex and KRAS Mutations

2006 • 296 citations

Association of Smoking, CpG Island Methylator Phenotype, and V600E BRAF Mutations in Colon Cancer

2006 • 266 citations

CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer.

2003 • 263 citations

Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands

2002 • 257 citations

Colorectal Cancer With Mutation in BRAF, KRAS, and Wild-Type With Respect to Both Oncogenes Showing Different Patterns of DNA Methylation

2004 • 218 citations

High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas

2007 • 210 citations

Adverse Prognostic Effect of Methylation in Colorectal Cancer Is Reversed by Microsatellite Instability

2003 • 194 citations

Association between DNA Methylation and Shortened Survival in Patients with Advanced Colorectal Cancer Treated with 5-Fluorouracil–Based Chemotherapy

2007 • 182 citations

Colorectal cancer: a model for epigenetic tumorigenesis

2006 • 176 citations

Clinicopathological features of CpG island methylator phenotype‐positive colorectal cancer and its adverse prognosis in relation to KRAS/BRAF mutation

2008 • 138 citations

Who to treat with adjuvant therapy in Dukes B/stage II colorectal cancer? The need for high quality pathology

2007 • 135 citations

CpG island methylator phenotype (CIMP) in cancer: Causes and implications

2008 • 132 citations

Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer.

2002 • 128 citations

CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma

2007 • 122 citations

Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer

2007 • 111 citations

Serrated pathway colorectal cancer in the population: genetic consideration

2007 • 95 citations

Correlation of β-Catenin Localization with Cyclooxygenase-2 Expression and CpG Island Methylator Phenotype (CIMP) in Colorectal Cancer

2007 • 82 citations

CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci

2008 • 70 citations

18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high

2007 • 57 citations

The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile

2008 • 53 citations

Human colorectal mucosal O6-alkylguanine DNA-alkyltransferase activity and DNA-N7-methylguanine levels in colorectal adenoma cases and matched referents

2006 • 21 citations

Colorectal cancer with mutation in BRAF, KRAS and wild-type with respect to both oncogenes showing different patterns of DNA methylation

2005 • 17 citations

Jaundice in a chronic hepatitis B carrier

2007 • 8 citations

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