Relative role of methylator and tumor suppressor pathways in ulcerative colitis-associated colon cancer

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

The risk of colorectal cancer in ulcerative colitis: a meta-analysis

2001 • 2,788 citations

CpG island methylator phenotype in colorectal cancer

1999 • 2,476 citations

Genetic instability in colorectal cancers

1997 • 1,989 citations

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

2006 • 1,883 citations

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 • 1,852 citations

Impact of mutant p53 functional properties onTP53mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

2007 • 1,523 citations

MethyLight: a high-throughput assay to measure DNA methylation

2000 • 1,382 citations

Classification of colorectal cancer based on correlation of clinical, morphological and molecular features

2006 • 1,327 citations

Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability.

1998 • 855 citations

Histologic Inflammation Is a Risk Factor for Progression to Colorectal Neoplasia in Ulcerative Colitis: A Cohort Study

2007 • 744 citations

Accelerated age-related CpG island methylation in ulcerative colitis.

2001 • 624 citations

Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification.

1999 • 475 citations

Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes.

1996 • 465 citations

Molecular Classification and Correlates in Colorectal Cancer

2007 • 444 citations

Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma.

2000 • 363 citations

Breast-Cancer Stromal Cells withTP53Mutations and Nodal Metastases

2007 • 293 citations

DNA Methylation and Environmental Exposures in Human Hepatocellular Carcinoma

2002 • 249 citations

DNA Methylation Analysis by MethyLight Technology

2001 • 143 citations

The APC/β‐catenin pathway in ulcerative colitis–related colorectal carcinomas

2002 • 136 citations

Genetic and epigenetic classifications define clinical phenotypes and determine patient outcomes in colorectal cancer

2009 • 104 citations

Chromosomal alterations in ulcerative colitis-related neoplastic progression

1997 • 101 citations

Rare CpG Island Methylator Phenotype in Ulcerative Colitis–Associated Neoplasias

2007 • 92 citations

Altered Distribution of β-Catenin, and Its Binding Proteins E-Cadherin and APC, in Ulcerative Colitis–Related Colorectal Cancers

2001 • 83 citations

Divergent Oncogenic Changes Influence Survival Differences between Colon and Rectal Adenocarcinomas

2009 • 76 citations

The p53 mutation “gradient effect” and its clinical implications

2007 • 71 citations

CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels

2008 • 61 citations

CpG Island Methylator Phenotype Association with Elevated Serum α-Fetoprotein Level in Hepatocellular Carcinoma

2007 • 59 citations

CpG Island Methylator Phenotype in Colorectal Cancers: Comparison of the New and Classic CpG Island Methylator Phenotype Marker Panels

2008 • 56 citations

Microsatellite instability and MLH1 promoter hypermethylation in colorectal cancer

2007 • 55 citations

Distinct methylated profiles in Helicobacter pylori dependent and independent gastric MALT lymphomas

2003 • 54 citations

Usefulness of analysis of p53 alteration and observation of surface microstructure for diagnosis of ulcerative colitis-associated colorectal neoplasia.

2003 • 35 citations

Disruption of the p53-p53r2 DNA repair system in ulcerative colitis contributes to colon tumorigenesis

2005 • 31 citations

Combined α-methylacyl coenzyme A racemase/p53 analysis to identify dysplasia in inflammatory bowel disease

2008 • 30 citations

Who takes the lead in the development of ulcerative colitis–associated colorectal cancers: mutator, suppressor, or methylator pathway?

2005 • 20 citations