Dopamine, depression and antidepressants

What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?

1998 • 3,973 citations

Dopamine Receptors: From Structure to Function

1998 • 3,489 citations

Chronic mild stress-induced anhedonia: A realistic animal model of depression

1992 • 1,120 citations

Adenosine–dopamine receptor–receptor interactions as an integrative mechanism in the basal ganglia

1997 • 804 citations

Dopamine receptors and brain function

1996 • 564 citations

Role of Neurotrophic Factors in the Etiology and Treatment of Mood Disorders

2004 • 529 citations

Blockade of the Noradrenaline Carrier Increases Extracellular Dopamine Concentrations in the Prefrontal Cortex: Evidence that Dopamine Is Taken up In Vivo by Noradrenergic Terminals

1990 • 407 citations

Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test

1999 • 379 citations

Dopamine and depression

1993 • 349 citations

Preliminary Randomized, Double-Blind, Placebo-Controlled Trial of Pramipexole Added to Mood Stabilizers for Treatment-Resistant Bipolar Depression

2004 • 347 citations

Increase of extracellular dopamine in the prefrontal cortex: a trait of drugs with antidepressant potential?

1994 • 317 citations

Reduced Brain Norepinephrine and Dopamine Release in Treatment-Refractory Depressive Illness

2000 • 291 citations

Perfusate serotonin increases extracellular dopamine in the nucleus accumbens as measured by in vivo microdialysis

1993 • 256 citations

5-hydroxytryptamine1B receptors block the GABAB synaptic potential in rat dopamine neurons

1992 • 247 citations

Role of 5-HT2C receptors in the control of central dopamine function

2001 • 236 citations

Synergistic Effects of Olanzapine and Other Antipsychotic Agents in Combination with Fluoxetine on Norepinephrine and Dopamine Release in Rat Prefrontal Cortex

2000 • 231 citations

NEW INSIGHTS INTO DOPAMINERGIC RECEPTOR FUNCTION USING ANTISENSE AND GENETICALLY ALTERED ANIMALS

1999 • 220 citations

Serotonin-dopamine interaction in the rat ventral tegmental area: an electrophysiological study in vivo.

1994 • 210 citations

Behavioral and biochemical effects of the antidepressant bupropion (Wellbutrin): evidence for selective blockade of dopamine uptake in vivo.

1980 • 203 citations

Parallel changes in dopamine D2 receptor binding in limbic forebrain associated with chronic mild stress-induced anhedonia and its reversal by imipramine

1994 • 201 citations

Dopamine D2 receptors in depression measured with single photon emission computed tomography

1994 • 191 citations

Differential effects of acute and chronic fluoxetine administration on the spontaneous activity of dopaminergic neurones in the ventral tegmental area

1995 • 179 citations

Striatal dopamine transporter density in major depression

1999 • 173 citations

Inactivation of 5-HT2C Receptors Potentiates Consequences of Serotonin Reuptake Blockade

2004 • 156 citations

Bupropion occupancy of the dopamine transporter is low during clinical treatment

2002 • 146 citations

Antidepressant-like actions of DOV 21,947: a “triple” reuptake inhibitor

2003 • 143 citations

Pramipexole in treatment‐resistant depression: a 16‐week naturalistic study

2002 • 141 citations

Reversal of stress-induced anhedonia by the dopamine receptor agonist, pramipexole

1994 • 131 citations

Anhedonia in Schizophrenic, Depressed, or Alcohol-Dependent Patients - Neurobiological Correlates

1994 • 125 citations

Pramipexole augmentation in the treatment of unipolar and bipolar depression: a retrospective chart review.

2000 • 125 citations

The effects of tyrosine depletion in normal healthy volunteers: implications for unipolar depression

2004 • 124 citations

Adenosine A _2A receptors and depression

2003 • 118 citations

Akinesia: A syndrome common to parkinsonism, retarded depression, and negative symptoms of schizophrenia

1992 • 118 citations

Evidence that Extracellular Concentrations of Dopamine Are Regulated by Noradrenergic Neurons in the Frontal Cortex of Rats

1994 • 115 citations

What Role Do Atypical Antipsychotic Drugs Have in Treatment-Resistant Depression?

2002 • 108 citations

Amantadine as augmentation therapy in the management of treatment-resistant depression

2003 • 100 citations

Pramipexole Augmentation in the Treatment of Unipolar and Bipolar Depression: A Retrospective Chart Review

2000 • 100 citations

Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT)1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535

1998 • 99 citations

Is dopamine implicated in the antidepressant-like effects of selective serotonin reuptake inhibitors in the mouse forced swimming test?

2001 • 94 citations

“Broad spectrum” antidepressants: Is more better for the treatment of depression?

2003 • 90 citations

The behavioural effects of pramipexole, a novel dopamine receptor agonist

1997 • 87 citations

Fluoxetine Increases Extracellular Dopamine in the Prefrontal Cortex by a Mechanism Not Dependent on Serotonin

1999 • 86 citations

Presynaptic dopamine release is enhanced by 5‐HT₃ receptor activation in medial prefrontal cortex of freely moving rats

1992 • 84 citations

Typical antipsychotic drugs — D2 receptor occupancy and depressive symptoms in schizophrenia

2002 • 78 citations

Modulation of dopamine release in the nucleus accumbens by 5-HT1B agonists: involvement of the hippocampo-accumbens pathway

1996 • 77 citations

Serotonin 1B receptor stimulation enhances dopamine-mediated reinforcement

1996 • 76 citations

The effects of antidepressants and electroconvulsive shocks on the functioning of the mesolimbic dopaminergic system: A behavioral study

1987 • 72 citations

Desipramine given repeatedly enhances behavioural effects of dopamine and d-amphetamine injected into the nucleus accumbens

1987 • 64 citations

Biochemistry and pharmacology of reversible inhibitors of MAO-A agents: focus on moclobemide.

1993 • 59 citations

Psychopathological Symptoms of Depression in Parkinson’s Disease Compared to Major Depression

2003 • 57 citations

Brain-derived neurotrophic factor controls dopamine D3 receptor expression: Implications for neurodevelopmental psychiatric disorders

2002 • 53 citations

Anxious?depressive symptoms in schizophrenia: a new treatment target for pharmacotherapy?

1999 • 47 citations

Regulation of serotonin-facilitated dopamine release in vivo: The role of protein kinase A activating transduction mechanisms

1996 • 43 citations

The role of the mesolimbic dopaminergic system in the despramine effect in the forced swimming test

1990 • 41 citations

S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity.

1997 • 40 citations

Anhedonia, Self-Experience in Schizophrenia, and Implications for Treatment

2003 • 39 citations

Dopamine Autoreceptor Agonists in the Treatment of Schizophrenia and Major Depression*

1992 • 38 citations

Indirect dopamine agonists effects on despair test: Dissociation from hyperactivity

1996 • 36 citations

Tyrosine hydroxylase, aromatic l-amino acid decarboxylase and dopamine metabolism after chronic treatment with dopaminergic drugs

1999 • 32 citations

Dopamine and melatonin in the nucleus accumbens may be implicated in the mode of action of antidepressant drugs

1992 • 30 citations

5-HT-moduline, a 5-HT1B/1D receptor endogenous modulator, interacts with dopamine release measured in vivo by microdialysis

1998 • 22 citations

Addition of a Dopamine Agonist, Cabergoline, to a Serotonin-Noradrenalin Reuptake Inhibitor, Milnacipran as a Therapeutic Option in the Treatment of Refractory Depression: Two Case Reports

2003 • 22 citations

Influence of depressive symptoms and premorbid adjustment on factor structure of phenomenology of schizophrenia: a study from India

2003 • 18 citations

Dose-dependent augmentation effect of bromocriptine in a case with refractory depression

2001 • 10 citations