Parallel changes in dopamine D2 receptor binding in limbic forebrain associated with chronic mild stress-induced anhedonia and its reversal by imipramine

Statistical principles in experimental design.

1962 • 27,228 citations

Statistical Principles in Experimental Design

1964 • 8,376 citations

Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

1987 • 1,858 citations

Chronic mild stress-induced anhedonia: A realistic animal model of depression

1992 • 1,120 citations

An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress

1991 • 514 citations

Antidepressant treatment prevents chronic unpredictable mild stress-induced anhedonia as assessed by ventral tegmentum self-stimulation behavior in rats

1992 • 249 citations

Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline

1992 • 238 citations

[3H]SCH 23390 binding to D1 dopamine receptors in the basal ganglia of the cat and primate: Delineation of striosomal compartments and pallidal and nigral subdivisions

1988 • 154 citations

Dopaminergic mechanism of imipramine action in an animal model of depression

1990 • 122 citations

Chronic treatment with antidepressants decreases the number of [3H]SCH 23390 binding sites in the rat striatum and limbic system

1987 • 118 citations

Reversal of antidepressant action by dopamine antagonists in an animal model of depression

1991 • 116 citations

Effects of imipramine on serotonergic and beta-adrenergic receptor binding in a realistic animal model of depression

1994 • 109 citations

Cholinergic-dopaminergic interactions and the mechanisms of action of antidepressants

1983 • 96 citations

Possible role of dopamine D1 receptor in the behavioural supersensitivity to dopamine agonists induced by chronic treatment with antidepressants

1990 • 91 citations

Attenuation of place preference conditioning but not place aversion conditioning by chronic mild stress

1992 • 86 citations

Subsensitivity to rewarding and locomotor stimulant effects of a dopamine agonist following chronic mild stress

1993 • 83 citations

Changes in mesolimbic dopamine may explain stress-induced anhedonia

1991 • 79 citations

Repeated treatment with antidepressant drugs increases the behavioural response to apomorphine

1984 • 77 citations

Repeated treatment with antidepressant drugs potentiates the locomotor response to (+)-amphetamine

1984 • 66 citations

Desipramine given repeatedly enhances behavioural effects of dopamine and d-amphetamine injected into the nucleus accumbens

1987 • 64 citations

Voltammetric evidence that subsensitivity to reward following chronic mild stress is associated with increased release of mesolimbic dopamine

1991 • 59 citations

Effects of Moclobemide, a New Generation Reversible Mao-A Inhibitor, in a Novel Animal Model of Depression

1993 • 58 citations

Repeated treatment with imipramine or amitriptyline increases the locomotor response of rats to (+)-amphetamine given into the nucleus accumbens

1985 • 54 citations

Prolonged treatment with the specific 5-HT-uptake inhibitor citalopram: effect on dopaminergic and serotonergic functions.

1984 • 51 citations

Repeated Administration of Antidepressants Enhances Agonist Affinity for Mesolimbic D2-Receptors

1989 • 49 citations

Stereospecific reversal of stress-induced anhedonia by mianserin and its (+)-enantiomer

1994 • 48 citations

The influence of repeated treatment with imipramine, (+)- and (?)-oxaprotiline on behavioural effects of dopamine D-1 and D-2 agonists

1989 • 47 citations

A mosaic-like distribution of dopamine receptors in rat neostriatum and its relationship to striosomes

1987 • 40 citations

Behavioural changes during withdrawal from desmethylimipramine (DMI)

1981 • 33 citations

Effect of desipramine on dopamine receptor binding in vivo

1990 • 27 citations

The influence of oxaprotiline enantiomers given repeatedly on the behavioural effects of d-amphetamine and dopamine injected into the nucleus accumbens

1988 • 26 citations

Attenuation of response to antidepressants in animals induced by reduction in food intake

1989 • 16 citations

Down-regulation of dopamine1 (D1) receptors by chronic imipramine is species-specific

1991 • 13 citations

Day/night differences in D1 but not D2 DA receptor protection from EEDQ denaturation in rats treated with continuous cocaine

1993 • 9 citations