Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test

Depression: a new animal model sensitive to antidepressant treatments

1977 • 4,272 citations

Behavioural despair in rats: A new model sensitive to antidepressant treatments

1978 • 3,035 citations

p-Chlorophenylalanine: a specific depletor of brain serotonin.

1966 • 1,754 citations

Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants

1995 • 1,404 citations

The spectrum of behaviors influenced by serotonin

1998 • 1,126 citations

Is the forced swimming test a suitable model for revealing antidepressant activity?

1988 • 1,053 citations

The role of defeat and entrapment (arrested flight) in depression: an exploration of an evolutionary view

1998 • 852 citations

The forced swimming test as a model for core and component behavioral effects of antidepressant drugs

1997 • 788 citations

Prozac (fluoxetine, lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: Twenty years since its first publication

1995 • 634 citations

The Revised Monoamine Theory of Depression: A Modulatory Role for Monoamines, Based on New Findings From Monoamine Depletion Experiments in Humans

1996 • 382 citations

Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression.

1997 • 298 citations

Parachlorophenylalanine Reversal of Tranylcypromine Effects in Depressed Patients

1976 • 263 citations

Pharmacology of Antidepressants—Characteristics of the Ideal Drug

1994 • 252 citations

Antidepressant behavioral effects by dual inhibition of monoamine reuptake in the rat forced swimming test

1998 • 246 citations

Role of the serotonergic system in the forced swimming test

1995 • 241 citations

Antidepressant-like activity of 5-HT1A agonists measured with the forced swim test

1990 • 225 citations

Rapid serotonin depletion as a provocative challenge test for patients with major depression: relevance to antidepressant action and the neurobiology of depression.

1991 • 191 citations

Monoamines and the mechanism of antidepressant action: effects of catecholamine depletion on mood of patients treated with antidepressants.

1993 • 158 citations

Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients.

1975 • 156 citations

Antidepressant-like behavioral effects of serotonin receptor agonists

1994 • 149 citations

Discovery of antidepressant activity by forced swimming test may depend on pre-exposure of rats to a stressful situation

1989 • 114 citations

Searching—waiting strategy: A candidate for an evolutionary model of depression?

1984 • 107 citations

Do noradrenaline and serotonin differentially affect social motivation and behaviour?

1997 • 85 citations

Evidence for involvement of 5-hydroxytryptamine1 receptors in antidepressant-like drug effects on differential-reinforcement-of-low-rate 72-second behavior.

1989 • 81 citations

Psychopharmacological profile of the selective serotonin reuptake inhibitor, paroxetine: implication of noradrenergic and serotonergic mechanisms

1998 • 68 citations

Role of central serotonergic neurons in the effect of sertraline in rats in the forced swimming test

1991 • 58 citations

The lesion of serotonergic neurons does not prevent antidepressant-induced reversal of escape failures produced by inescapable shocks in rats

1986 • 50 citations

An Analysis of the Effects of Acute and Chronic Fluoxetine on Extracellular Norepinephrine in the Rat Hippocampus during Stress

1997 • 45 citations

Selective Serotonin/Noradrenaline Reuptake Inhibitors (SNRIs)

1995 • 44 citations

Imipramine and fluoxetine prevent the stress-induced escape deficits in rats through a distinct mechanism of action

1995 • 41 citations