Signaling by the G Class of G Proteins

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Receptor-effector coupling by G proteins

1990 • 1,117 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

Protein kinase C - a question of specificity

1994 • 958 citations

MAPKs: new JNK expands the group

1994 • 949 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

The 2.2 Å crystal structure of transducin-α complexed with GTPγS

1993 • 788 citations

Protein Lipidation in Cell Signaling

1995 • 771 citations

THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONS

1989 • 739 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

Substitution of three amino acids switches receptor specificity of Gqα to that of Giα

1993 • 702 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

Role of phosphoinositides in transmembrane signaling.

1990 • 491 citations

Diversity in function and regulation of MAP kinase pathways

1994 • 469 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH

1984 • 447 citations

Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly

1995 • 443 citations

Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator

1992 • 430 citations

Selectivity in Signal Transduction Determined by γ Subunits of Heterotrimeric G Proteins

1993 • 393 citations

Rho as a regulator of the cytoskeleton

1995 • 386 citations

Purification of Recombinant G Proteins from Sf9 Cells by Hexahistidine Tagging of Associated Subunits

1995 • 332 citations

Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP

1992 • 324 citations

Association between GTPase activators for Rho and Ras families

1992 • 322 citations

The drosophila gastrulation gene concertina encodes a Gα-like protein

1991 • 319 citations

A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation

1994 • 317 citations

The dynamic role of palmitoylation in signal transduction

1995 • 315 citations

The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion.

1993 • 205 citations

Activation of Jun Kinase/Stress-activated Protein Kinase by GTPase-deficient Mutants of Gα12 and Gα13

1995 • 178 citations

Direct Interaction between Ras and the Kinase Domain of Mitogen-activated Protein Kinase Kinase Kinase (MEKK1)

1995 • 177 citations

G alpha 13 stimulates Na-H exchange.

1994 • 175 citations

Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product.

1993 • 145 citations

Covalent binding of arachidonate to G protein alpha subunits of human platelets.

1994 • 118 citations

Protein kinase C-dependent and -independent activation of Na+/H+ exchanger by G alpha 12 class of G proteins.

1994 • 109 citations

The transforming activity of activated Gα12

1993 • 100 citations

Potent Transforming Activity of the G13 α Subunit Defines a Novel Family of Oncogenes

1994 • 99 citations

Adenovirus E1A negatively and positively modulates transcription of AP-1 dependent genes by dimer-specific regulation of the DNA binding and transactivation activities of Jun.

1993 • 98 citations

Specific interaction with rhodopsin is dependent on the gamma subunit type in a G protein.

1993 • 97 citations

G12 Requirement for Thrombin-stimulated Gene Expression and DNA Synthesis in 1321N1 Astrocytoma Cells

1995 • 96 citations

Purification and characterization of the alpha subunit of G13.

1994 • 75 citations

G12 and G13 α-Subunits Are Immunochemically Detectable in Most Membranes of Various Mammalian Cells and Tissues

1994 • 64 citations

Mitogen-activated Protein Kinase Activation Requires Two Signal Inputs from the Human Anaphylatoxin C5a Receptor

1995 • 63 citations

The α‐subunits of G‐proteins G₁₂ and G₁₃ are palmitoylated, but not amidically myristoylated

1994 • 63 citations

Differential response of the Ras exchange factor, Ras-GRF to tyrosine kinase and G protein mediated signals.

1995 • 58 citations

Na+/H+ exchange as a modulator of platelet activation

1988 • 55 citations

The G protein G13 mediates inhibition of voltage-dependent calcium current by bradykinin

1994 • 45 citations

Fluoxetine modulates G protein αs, αq and α12 subunit mRNA expression in rat brain

1992 • 29 citations

Immunological identification of the α subunit of G13, a novel guanine nucleotide binding protein

1992 • 23 citations

Osmotic activation of the Na+/H+ antiporter during volume regulation

1994 • 20 citations

Genetic and structural analysis of G protein α subunit regulatory domains

1991 • 19 citations

Purification of the G-protein G13 from rat brain membranes

1994 • 15 citations

Rapid Isolation of Gα13 from Bovine Brain Membranes: Supportive Effect of Ethylene Glycol

1994 • 3 citations