Evidence for an interferon-related inflammatory reaction in the trisomy 16 mouse brain leading to caspase-1-mediated neuronal apoptosis

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

1993 • 2,272 citations

The Atlas of Mouse Development

1992 • 1,782 citations

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

The atlas of mouse development

1993 • 1,427 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.

1992 • 857 citations

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

1995 • 741 citations

TRISOMY IN MAN

1984 • 652 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits

1992 • 537 citations

Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro

1995 • 505 citations

The role of calcium in apoptosis

1998 • 465 citations

Induction of MHC Class I Genes in Neurons

1995 • 446 citations

Alzheimer's disease in Down's syndrome

1985 • 393 citations

Expression of a Dominant Negative Mutant of Interleukin-1β Converting Enzyme in Transgenic Mice Prevents Neuronal Cell Death Induced by Trophic Factor Withdrawal and Ischemic Brain Injury

1997 • 345 citations

A glutamate receptor channel with high affinity for domoate and kainate.

1992 • 336 citations

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease

1997 • 300 citations

Interferon-γ Modulates a p53-independent Apoptotic Pathway and Apoptosis-related Gene Expression

1997 • 276 citations

The neurobiologie consequences of down syndrome

1986 • 249 citations

Interferon γ Induces Upregulation and Activation of Caspases 1, 3, and 8 to Produce Apoptosis in Human Erythroid Progenitor Cells

1999 • 206 citations

The Purification and Characterization of Rat Gamma Interferon by Use of Two Monoclonal Antibodies

1986 • 204 citations

Role of intracellular pH in proliferation, transformation, and apoptosis.

1997 • 191 citations

Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures

1998 • 189 citations

Brain inflammation in Alzheimer disease and the therapeutic implications.

1999 • 177 citations

CD95 (Fas/Apo-1) as a Receptor Governing Astrocyte Apoptotic or Inflammatory Responses: A Key Role in Brain Inflammation?

1999 • 149 citations

Brain Inflammation in Alzheimer Disease and the Therapeutic Implications

1999 • 148 citations

CYTOKINE-MEDIATED NEURONAL APOPTOSIS

1997 • 146 citations

Human Chromosome 21 Dosage: Effect on the Expression of the Interferon Induced Antiviral State

1974 • 143 citations

Interferon γ Gene Expression in Sensory Neurons: Evidence for Autocrine Gene Regulation

1997 • 133 citations

Mechanisms of neuronal death in brain aging and alzheimer's disease: Role of endocrine‐mediated calcium dyshomeostasis

1992 • 118 citations

The Neurobiology of Down Syndrome

1987 • 113 citations

ICE, neuronal apoptosis and neurodegeneration

1998 • 105 citations

Neuronal interferon‐γ immunoreactive molecule: Bioactivities and purification

1994 • 84 citations

Interferon‐gamma‐like immunoreactivity in certain neurons of the central and peripheral nervous system

1989 • 83 citations

Glutamate as a hippocampal neuron survival factor: an inherited defect in the trisomy 16 mouse.

1995 • 78 citations

Animal models in the study of the biological function of genes on human chromosome 21 and their role in the pathophysiology of Down syndrome

1997 • 71 citations

Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome

1999 • 71 citations

Tumor necrosis factor-alpha and IFN-gamma expression in human thymus. Localization and overexpression in Down syndrome (trisomy 21).

1992 • 70 citations

The Neurobiology of Down syndrome

1986 • 68 citations

Neurons induced to express major histocompatibility complex class I antigen are killed via the perforin and not the Fas (APO‐1/CD95) pathway

1996 • 66 citations

Chromosome 21 and the cell growth inhibitory effect of human interferon preparations

1976 • 65 citations

The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis.

1993 • 65 citations

Altered Ca²⁺Signaling and Mitochondrial Deficiencies in Hippocampal Neurons of Trisomy 16 Mice: A Model of Down’s Syndrome

1998 • 64 citations

γ-Interferon promotes differentiation of cultured cortical and hippocampal neurons

1991 • 61 citations

Fas Antigen Modulates Ultraviolet B-Induced Apoptosis of SVHK Cells: Sequential Activation of Caspases 8, 3, and 1 in the Apoptotic Process

1999 • 59 citations

Assignment of the Murine Interferon Sensitivity and Cytoplasmic Superoxide Dismutase Genes to Chromosome 16

1980 • 58 citations

Interferon-γ promotes cholinergic differentiation of embryonic septal nuclei and adjacent basal forebrain

1994 • 54 citations

Gamma interferon-like immunoreactivity in the rat nervous system

1990 • 47 citations

Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.

1993 • 44 citations

The neuropathology of the trisomy 16 mouse.

1994 • 41 citations

Partial IFN-alpha/betaand IFN-gammaReceptor Knockout Trisomy 16 Mouse Fetuses Show Improved Growth and Cultured Neuron Viability

2000 • 41 citations

Calcium signals in cell lines derived from the cerebral cortex of normal and trisomy 16 mice

1999 • 40 citations

Gamma interferon-like immunoreactive material in rat neurons: Evidence against a close relationship to gamma interferon

1991 • 36 citations

Nerve growth factor corrects developmental impairments of basal forebrain cholinergic neurons in the trisomy 16 mouse.

1991 • 34 citations

Neuronal Apoptosis in Mouse Trisomy 16

1999 • 33 citations

Abnormal calcium homeostasis in astrocytes from the trisomy 16 mouse

1997 • 32 citations

Impaired Ca-signaling in astrocytes from the Ts16 mouse model of Down syndrome

1997 • 22 citations

Anti‐interferon immunoglobulins can improve the trisomy 16 mouse phenotype

1995 • 22 citations

Glutathione levels and nerve cell loss in hippocampal cultures from trisomy 16 mouse – a model of Down syndrome

1997 • 22 citations

Anti-gamma interferon can prevent the premature death of trisomy 16 mouse cortical neurons in culture

1998 • 18 citations

Neuronal IFN-γ in tuberomammillary neurones

1994 • 17 citations

A Microfluorometric Method for Simultaneous Measurement of Changes in Cytosolic Free Calcium Concentration and pH in Single Cardiac Myocytes.

1991 • 15 citations

Decreased sensitivity to nerve growth factor of dorsal root ganglion neurons cultured from mouse trisomy 16, a model of Down's syndrome

1995 • 6 citations