The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

2007 • 4,197 citations

Regulated portals of entry into the cell

2003 • 3,642 citations

Loss of autophagy in the central nervous system causes neurodegeneration in mice

2006 • 3,331 citations

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

2005 • 3,045 citations

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

2004 • 2,265 citations

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

2001 • 1,373 citations

Receptor downregulation and multivesicular-body sorting

2002 • 1,192 citations

Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

2003 • 1,102 citations

Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria

2006 • 897 citations

Escrt-III

2002 • 854 citations

The Protein Network of HIV Budding

2003 • 806 citations

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

2003 • 794 citations

Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis

1996 • 789 citations

Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

2005 • 783 citations

Parallels Between Cytokinesis and Retroviral Budding: A Role for the ESCRT Machinery

2007 • 729 citations

The emerging shape of the ESCRT machinery

2007 • 712 citations

The biogenesis of multivesicular endosomes

2004 • 694 citations

Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

2002 • 692 citations

Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis

2007 • 663 citations

Endosome-Associated Complex, ESCRT-II, Recruits Transport Machinery for Protein Sorting at the Multivesicular Body

2002 • 629 citations

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

2002 • 626 citations

Membrane scission by the ESCRT-III complex

2009 • 594 citations

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

2007 • 591 citations

RETROVIRUS BUDDING

2004 • 542 citations

Differential Regulation of EGF Receptor Internalization and Degradation by Multiubiquitination within the Kinase Domain

2006 • 526 citations

Phosphatidylinositol(3)-Phosphate Signaling Mediated by Specific Binding to RING FYVE Domains

1998 • 497 citations

ESCRT-III Dysfunction Causes Autophagosome Accumulation and Neurodegeneration

2007 • 449 citations

Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes

2003 • 448 citations

Vps27 recruits ESCRT machinery to endosomes during MVB sorting

2003 • 445 citations

ESCRT complexes and the biogenesis of multivesicular bodies

2008 • 441 citations

A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems

2001 • 438 citations

Plasma membrane deformation by circular arrays of ESCRT-III protein filaments

2008 • 417 citations

ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)

2006 • 378 citations

Hrs recruits clathrin to early endosomes

2001 • 374 citations

The Drosophila Tumor Suppressor vps25 Prevents Nonautonomous Overproliferation by Regulating Notch Trafficking

2005 • 348 citations

The Vps27p–Hse1p complex binds ubiquitin and mediates endosomal protein sorting

2002 • 345 citations

A Role for the ESCRT System in Cell Division in Archaea

2008 • 343 citations

Bilayered Clathrin Coats on Endosomal Vacuoles Are Involved in Protein Sorting toward Lysosomes

2002 • 338 citations

Helical Structures of ESCRT-III Are Disassembled by VPS4

2008 • 332 citations

tsg101: A Novel Tumor Susceptibility Gene Isolated by Controlled Homozygous Functional Knockout of Allelic Loci in Mammalian Cells

1996 • 332 citations

Ubiquitination Mediated by the Npi1p/Rsp5p Ubiquitin-protein Ligase Is Required for Endocytosis of the Yeast Uracil Permease

1996 • 316 citations

Ordered Assembly of the ESCRT-III Complex on Endosomes Is Required to Sequester Cargo during MVB Formation

2008 • 314 citations

Tumor Suppressor Properties of the ESCRT-II Complex Component Vps25 in Drosophila

2005 • 312 citations

Regulation of ubiquitin-binding proteins by monoubiquitination

2006 • 309 citations

FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes

2001 • 302 citations

Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4

2007 • 299 citations

The Doa4 Deubiquitinating Enzyme Is Functionally Linked to the Vacuolar Protein-sorting and Endocytic Pathways

2000 • 299 citations

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation

2003 • 298 citations

Functional Reconstitution of ESCRT-III Assembly and Disassembly

2009 • 290 citations

Mutations in erupted, the Drosophila Ortholog of Mammalian Tumor Susceptibility Gene 101, Elicit Non-Cell-Autonomous Overgrowth

2005 • 288 citations

The Doa4 Deubiquitinating Enzyme Is Required for Ubiquitin Homeostasis in Yeast

1999 • 285 citations

Evolution of the Multivesicular Body ESCRT Machinery; Retention Across the Eukaryotic Lineage

2008 • 256 citations

The Ubiquitin Isopeptidase UBPY Regulates Endosomal Ubiquitin Dynamics and Is Essential for Receptor Down-regulation

2006 • 246 citations

ESCRT-I Core and ESCRT-II GLUE Domain Structures Reveal Role for GLUE in Linking to ESCRT-I and Membranes

2006 • 230 citations

Interactions of GGA3 with the ubiquitin sorting machinery

2004 • 226 citations

Lysosomal system pathways: Genes to neurodegeneration in Alzheimer's disease

2006 • 224 citations

E3 Ubiquitin Ligases as Regulators of Membrane Protein Trafficking and Degradation

2005 • 223 citations

ESCRT-II, an Endosome-Associated Complex Required for Protein Sorting

2004 • 212 citations

ALIX-CHMP4 interactions in the human ESCRT pathway

2008 • 210 citations

Activation of the Endosome-Associated Ubiquitin Isopeptidase AMSH by STAM, a Component of the Multivesicular Body-Sorting Machinery

2006 • 191 citations

Degradation of Endocytosed Epidermal Growth Factor and Virally Ubiquitinated Major Histocompatibility Complex Class I Is Independent of Mammalian ESCRTII

2005 • 187 citations

Structure and Ubiquitin Binding of the Ubiquitin-interacting Motif

2003 • 183 citations

Eap45 in Mammalian ESCRT-II Binds Ubiquitin via a Phosphoinositide-interacting GLUE Domain

2005 • 175 citations

Depletion of TSG101 forms a mammalian `Class E' compartment: a multicisternal early endosome with multiple sorting defects

2005 • 173 citations

Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting

2006 • 168 citations

Molecular Architecture and Functional Model of the Complete Yeast ESCRT-I Heterotetramer

2007 • 168 citations

The Arabidopsis elch mutant reveals functions of an ESCRT component in cytokinesis

2006 • 168 citations

Structure of the ESCRT-II endosomal trafficking complex

2004 • 167 citations

Human ESCRT-II Complex and Its Role in Human Immunodeficiency Virus Type 1 Release

2006 • 163 citations

The Human Endosomal Sorting Complex Required for Transport (ESCRT-I) and Its Role in HIV-1 Budding

2004 • 160 citations

Growth Factor-Induced Tyrosine Phosphorylation of Hrs, a Novel 115-Kilodalton Protein with a Structurally Conserved Putative Zinc Finger Domain

1995 • 156 citations

Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains

2006 • 145 citations

Structure and Disassembly of Filaments Formed by the ESCRT-III Subunit Vps24

2008 • 135 citations

Spongiform Neurodegeneration-associated E3 Ligase Mahogunin Ubiquitylates TSG101 and Regulates Endosomal Trafficking

2007 • 133 citations

Structural Basis for Autoinhibition of ESCRT-III CHMP3

2008 • 130 citations

A Deubiquitinating Enzyme UBPY Regulates the Level of Protein Ubiquitination on Endosomes

2006 • 121 citations

Novel Ist1-Did2 Complex Functions at a Late Step in Multivesicular Body Sorting

2007 • 116 citations

Identification of Human MVB12 Proteins as ESCRT-I Subunits that Function in HIV Budding

2007 • 109 citations

Ubc4/5 and c-Cbl Continue to Ubiquitinate EGF Receptor after Internalization to Facilitate Polyubiquitination and Degradation

2008 • 107 citations

Integrated Structural Model and Membrane Targeting Mechanism of the Human ESCRT-II Complex

2008 • 96 citations

Hrs and SNX3 Functions in Sorting and Membrane Invagination within Multivesicular Bodies

2008 • 93 citations

The Role of Ubiquitin in Retroviral Egress

2007 • 93 citations

Acquisition of Hrs, an Essential Component of Phagosomal Maturation, Is Impaired by Mycobacteria

2004 • 91 citations

ESCRT factors restrict mycobacterial growth

2008 • 91 citations

Targeted Deletion of the Tsg101 Gene Results in Cell Cycle Arrest at G1/S and p53-independent Cell Death

2002 • 85 citations

An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor

2008 • 81 citations

HCRP1, a novel gene that is downregulated in hepatocellular carcinoma, encodes a growth-inhibitory protein

2003 • 79 citations

Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain

2006 • 77 citations

Interactions of TOM1L1 with the Multivesicular Body Sorting Machinery

2004 • 75 citations

Cloning of a Novel Signal-Transducing Adaptor Molecule Containing an SH3 Domain and ITAM

1996 • 73 citations

The Vps27/Hse1 Complex Is a GAT Domain-Based Scaffold for Ubiquitin-Dependent Sorting

2007 • 72 citations

The Crystal Structure of the C‐Terminal Domain of Vps28 Reveals a Conserved Surface Required for Vps20 Recruitment

2006 • 58 citations

New component of ESCRT-I regulates endosomal sorting complex assembly

2006 • 55 citations

Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain

2006 • 53 citations

Chmp1A functions as a novel tumor suppressor gene in human embryonic kidney and ductal pancreatic tumor cells

2008 • 52 citations

Evidence for a Direct Role of the Doa4 Deubiquitinating Enzyme in Protein Sorting into the MVB Pathway

2007 • 51 citations

ESCRTing autophagic clearance of aggregating proteins

2008 • 44 citations

Endofin Recruits TOM1 to Endosomes

2004 • 42 citations

WITHDRAWN: Endosomal trafficking of EGFR regulated by hVps18 via interaction of MVB sorting machinery

2007 • 7 citations