The crystal structure of Haelll methyltransferase covalently complexed to DNA: An extrahelical cytosine and rearranged base pairing

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

1992 • 3,863 citations

Conformation of Polypeptides and Proteins

1968 • 2,929 citations

Accurate bond and angle parameters for X-ray protein structure refinement

1991 • 2,467 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

Chemical and biological evolution of a nucleotide-binding protein

1974 • 1,457 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

Traitement statistique des erreurs dans la determination des structures cristallines

1952 • 1,284 citations

Crystal structure of a yeast TBP/TATA-box complex

1993 • 1,082 citations

Resolution of phase ambiguity in macromolecular crystallography

1985 • 1,040 citations

Co-crystal structure of TBP recognizing the minor groove of a TATA element

1993 • 1,039 citations

Hhal methyltransferase flips its target base out of the DNA helix

1994 • 936 citations

Interactive computer graphics: FRODO

1985 • 848 citations

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

1990 • 643 citations

MAMMALIAN X-CHROMOSOME INACTIVATION

1983 • 635 citations

Slow-cooling protocols for crystallographic refinement by simulated annealing

1990 • 530 citations

Trinucleotide repeat amplification and hypermethylation of a CpG island in FRAXE mental retardation

1993 • 522 citations

Structural studies of protein–nucleic acid interaction: the sources of sequence-specific binding

1990 • 508 citations

Predictive motifs derived from cytosine methyltransferases

1989 • 505 citations

Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex

1995 • 469 citations

Crystal structure of catechol O-methyltransferase

1994 • 426 citations

Kinetic and catalytic mechanism of HhaI methyltransferase.

1987 • 416 citations

On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs

1983 • 404 citations

Mounting of crystals for macromolecular crystallography in a free-standing thin film

1990 • 374 citations

Crystal Structure of LacI Member, PurR, Bound to DNA: Minor Groove Binding by α Helices

1994 • 369 citations

Physical mapping across the fragile X: Hypermethylation and clinical expression of the fragile X syndrome

1991 • 357 citations

Crystal structure of the Hhal DNA methyltransferase complexed with S-adenosyl-l-methionine

1993 • 357 citations

Methylation and Imprinting: from Host Defense to Gene Regulation?

1993 • 299 citations

Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability.

1990 • 264 citations

Crystal structure of the site-specific recombinase γδ resolvase complexed with a 34 by cleavage site

1995 • 248 citations

Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase

1991 • 246 citations

The Role of Dna Methylation in Cancer

1990 • 244 citations

DNA sequence duplications trigger gene inactivation in Neurospora crassa.

1988 • 235 citations

Cytosine-specific type II DNA methyltransferases

1989 • 230 citations

Abnormal pattern detected in fragile-X patients by pulsed-field gel electrophoresis

1991 • 213 citations

Parental imprinting of autosomal mammalian genes

1994 • 208 citations

Molecular Biology of DNA Methylation

1985 • 186 citations

Effect of anisotropy and anharmonicity on protein crystallographic refinement

1986 • 172 citations

Three-dimensional structure of the adenine-specific DNA methyltransferase M.Taq I in complex with the cofactor S-adenosylmethionine.

1994 • 168 citations

The abasic site as a challenge to DNA polymerase

1990 • 168 citations

Molecular biology of DNA methylation

1987 • 166 citations

Kinetics and energetics of base-pair opening in 5'-d(CGCGAATTCGCG)-3' and a substituted dodecamer containing G.cntdot.T mismatches

1992 • 117 citations

Sequential order of target-recognizing domains in multispecific DNA-methyltransferases.

1988 • 116 citations

Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2′-deoxyuridylate and 5,10-methylenetetrahydrofolate

1990 • 115 citations

Cryocrystallography

1994 • 109 citations

The sequence specificity domain of cytosine-C5 methylases

1991 • 108 citations

5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase

1988 • 106 citations

Base-pairing shift in the major groove of (CA)n tracts by B-DNA crystal structures

1991 • 97 citations

Construction and use of chimeric SPR/phi 3T DNA methyltransferases in the definition of sequence recognizing enzyme regions.

1987 • 96 citations

Schematic drawings of protein structures

1985 • 93 citations

Three-dimensional structures of bulge-containing DNA fragments

1992 • 90 citations

Organization of multispecific DNA methyltransferases encoded by temperate Bacillus subtilis phages.

1987 • 74 citations

Chimeric multispecific DNA methyltransferases with novel combinations of target recognition

1988 • 72 citations

Crystal structure of 15-mer DNA duplex containing unpaired bases

1988 • 68 citations

The flip side of DNA methylation

1994 • 62 citations

Constrained-restrained least-squares (CORELS) refinement of proteins and nucleic acids

1985 • 60 citations

Mutational separation of DNA binding from catalysis in a DNA cytosine methyltransferase

1993 • 55 citations

How M.Mspl and M.Hpall decide which base to methylate

1992 • 54 citations

Abasic frameshift in DNA. Solution conformation determined by proton NMR and molecular mechanics calculations

1989 • 49 citations

Characterization of the archaeal, plasmid-encoded type II restriction-modification system MthTI from Methanobacterium thermoformicicum THF: homology to the bacterial NgoPII system from Neisseria gonorrhoeae

1992 • 46 citations

DNA totally flipped-out by methylase

1994 • 14 citations

Crystallization and Preliminary Crystallographic Analysis of a DNA (Cytosine-5)-Methyltransferase from Haemophilus aegyptius Bound Covalently to DNA

1994 • 7 citations