Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways.

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Oncogenes and signal transduction

1991 • 2,816 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1985 • 738 citations

Paxillin: a new vinculin-binding protein present in focal adhesions.

1990 • 687 citations

Molecular and biochemical characterization of the human trk proto-oncogene.

1989 • 600 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1986 • 421 citations

Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system

1990 • 375 citations

Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

1990 • 342 citations

Growth factor signaling: Where is the specificity?

1992 • 341 citations

Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation

1992 • 321 citations

Nerve growth factor receptors on PC12 cells: Evidence for two receptor classes with differing cytoskeletal association

1981 • 302 citations

trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues

1993 • 293 citations

Molecular Cloning of a Gene Sequence Regulated by Nerve Growth Factor

1985 • 279 citations

Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene.

1991 • 272 citations

The effect of fibroblast growth factor on PC12 cells

1985 • 270 citations

Two species of human CRK cDNA encode proteins with distinct biological activities.

1992 • 269 citations

Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.

1993 • 257 citations

Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions.

1991 • 255 citations

Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase.

1992 • 243 citations

Expression of Functional Nerve Growth Factor Receptors After Gene Transfer

1989 • 235 citations

Dissecting the Mode of Action of a Neuronal Growth Factor

1991 • 179 citations

Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation.

1989 • 176 citations

Expression of members of the trk family in the developing postnatal rat brain

1993 • 174 citations

Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells

1991 • 168 citations

Peptide growth factor control of olfactory neurogenesis and neuron survival in vitro: Roles of EGF and TGF-βs

1993 • 159 citations

NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation

1991 • 152 citations

The product of the cellular crk gene consists primarily of SH2 and SH3 regions.

1992 • 147 citations

Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells.

1991 • 131 citations

Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation

1990 • 128 citations

Tyrosine-phosphorylated epidermal growth factor receptor and cellular p130 provide high affinity binding substrates to analyze Crk-phosphotyrosine-dependent interactions in vitro.

1992 • 120 citations

Neuroblast mitosis in dissociated culture: regulation and relationship to differentiation.

1990 • 113 citations

Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells.

1993 • 100 citations

Phosphorylation of Nek in Response to a Variety of Receptors, Phorbol Myristate Acetate, and Cyclic AMP

1992 • 94 citations

Nerve growth factor-induced reduction in epidermal growth factor responsiveness and epidermal growth factor receptors in PC12 cells: An aspect of cell differentiation

1979 • 84 citations

Basic fibroblast growth factor prevents ontogenetic neuron death in vivo

1989 • 67 citations

Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.

1991 • 60 citations

Insulin and Insulin-Like Growth Factors Stimulate Deoxyribonucleic Acid Synthesis in PC 12 Pheochromocytoma Cells

1988 • 60 citations

Association of nerve growth factor receptors with the triton X-100 cytoskeleton of PC12 cells

1985 • 56 citations

Induction of basic fibroblast growth factor mRNA and protein synthesis in smooth muscle cells by cholesteryl ester enrichment and 25-hydroxycholesterol.

1993 • 49 citations

Characterization of Insulin-Like Growth Factor-I Receptors in PC 12 Pheochromocytoma Cells and Bovine Adrenal Medulla

1989 • 28 citations