Activity of the purified mutagenesis proteins UmuC, UmuD', and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III.

Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli

1984 • 1,608 citations

Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli

1976 • 1,572 citations

The SOS regulatory system of Escherichia coli

1982 • 1,491 citations

Discontinuities in the DNA synthesized in an Excision-defective strain of Escherichia coli following ultraviolet irradiation

1968 • 1,089 citations

FIDELITY MECHANISMS IN DNA REPLICATION

1991 • 709 citations

Molecular Mechanisms for Repair of DNA

1975 • 676 citations

Isolation and characterization of mutants of Escherichia coli deficient in induction of mutations by ultraviolet light

1977 • 567 citations

RecA-mediated cleavage activates UmuD for mutagenesis: mechanistic relationship between transcriptional derepression and posttranslational activation.

1988 • 415 citations

Induction of Mutations in a Bacterial Virus

1953 • 411 citations

Oligodeoxynucleotides containing synthetic abasic sites. Model substrates for DNA polymerases and apurinic/apyrimidinic endonucleases.

1987 • 399 citations

UmuD mutagenesis protein of Escherichia coli: overproduction, purification, and cleavage by RecA.

1988 • 354 citations

RecA protein-dependent cleavage of UmuD protein and SOS mutagenesis.

1988 • 349 citations

Inducibility of a gene product required for UV and chemical mutagenesis in Escherichia coli.

1981 • 279 citations

New recA mutations that dissociate the various RecA protein activities in Escherichia coli provide evidence for an additional role for RecA protein in UV mutagenesis

1989 • 235 citations

Uvm mutants of Escherichia coli K 12 deficient in UV mutagenesis

1978 • 233 citations

UmuC mutagenesis protein of Escherichia coli: purification and interaction with UmuD and UmuD'.

1989 • 222 citations

Nucleotide insertion kinetics opposite abasic lesions in DNA.

1987 • 209 citations

Mutation frequency and spectrum resulting from a single abasic site in a single-stranded vector

1990 • 200 citations

Levels of chromosomally encoded Umu proteins and requirements for in vivo UmuD cleavage

1991 • 177 citations

RecA protein of Escherichia coli has a third essential role in SOS mutator activity

1990 • 173 citations

DNA Polymerase III holoenzyme of Escherichia coli. IV. The holoenzyme is an asymmetric dimer with twin active sites.

1988 • 168 citations

Mutagenic repair in Escherichia coli: products of the recA gene and of the umuD and umuC genes act at different steps in UV-induced mutagenesis.

1985 • 166 citations

The polymerase subunit of DNA polymerase III of Escherichia coli. II. Purification of the alpha subunit, devoid of nuclease activities.

1985 • 164 citations

Mechanism of ultraviolet-induced mutagenesis: Extent and fidelity of in vitro DNA synthesis on irradiated templates

1978 • 160 citations

Capacity of RecA protein to bind preferentially to UV lesions and inhibit the editing subunit (epsilon) of DNA polymerase III: a possible mechanism for SOS-induced targeted mutagenesis.

1986 • 137 citations

Mechanism of transient inhibition of DNA synthesis in ultraviolet-irradiated E. coli: Inhibition is independent of recA whilst recovery requires RecA protein itself and an additional, inducible SOS function

1985 • 135 citations

Dominant negative umuD mutations decreasing RecA-mediated cleavage suggest roles for intact UmuD in modulation of SOS mutagenesis.

1990 • 130 citations

DNA polymerase II is encoded by the DNA damage-inducible dinA gene of Escherichia coli.

1990 • 129 citations

Processive replication is contingent on the exonuclease subunit of DNA polymerase III holoenzyme.

1990 • 128 citations

Processive DNA synthesis by DNA polymerase II mediated by DNA polymerase III accessory proteins.

1992 • 126 citations

Mutagenic DNA repair in Escherichia coli

1976 • 120 citations

Purification and characterization of an inducible Escherichia coli DNA polymerase capable of insertion and bypass at abasic lesions in DNA.

1988 • 118 citations

DNA polymerase III holoenzyme of Escherichia coli. II. A novel complex including the gamma subunit essential for processive synthesis.

1988 • 116 citations

Mutation induced by DNA damage: a many protein affair

1990 • 114 citations

Molecular Mechanisms for Repair of DNA

1975 • 113 citations

The Escherichia coli polB gene, which encodes DNA polymerase II, is regulated by the SOS system

1990 • 95 citations

Recovery from ultraviolet light-induced inhibition of DNA synthesis requires umuDC gene products in recA718 mutant strains but not in recA+ strains of Escherichia coli.

1987 • 91 citations

Contribution of 3′ → 5′ exonuclease activity of DNA polymerase III holoenzyme from Escherichia coli to specificity

1983 • 88 citations

groE mutants of Escherichia coli are defective in umuDC-dependent UV mutagenesis

1989 • 82 citations

Spontaneous and UV-induced mutations in Escherichia coli K-12 strains with altered or absent DNA polymerase I

1989 • 73 citations

DNA polymerase III of Escherichia coli is required for UV and ethyl methanesulfonate mutagenesis.

1987 • 71 citations

Genetic separation of Escherichia coli recA functions for SOS mutagenesis and repressor cleavage

1989 • 70 citations

RecA protein and SOS

1987 • 69 citations

Escherichia coli DNA polymerase II is stimulated by DNA polymerase III holoenzyme auxiliary subunits

1991 • 62 citations

Coexpression of UmuD' with UmuC suppresses the UV mutagenesis deficiency of groE mutants

1992 • 59 citations

Bypass and termination at apurinic sites during replication of single-stranded DNA in vitro: a model for apurinic site mutagenesis.

1988 • 55 citations

Mutation rate : Some biological and biochemical considerations

1982 • 52 citations

Requirements for bypass of UV-induced lesions in single-stranded DNA of bacteriophage phi X174 in Salmonella typhimurium.

1991 • 32 citations

Ultraviolet Mutagenesis in Strains of E. coli deficient in DNA Polymerase

1971 • 29 citations