Suppression of SHP-2 and ERK Signalling Promotes Self-Renewal of Mouse Embryonic Stem Cells

Establishment in culture of pluripotential cells from mouse embryos

1981 • 8,424 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

1981 • 5,629 citations

STATs and Gene Regulation

1997 • 3,927 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

A general method ofin vitropreparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

1988 • 2,410 citations

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

1988 • 2,004 citations

Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

1992 • 2,004 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

1998 • 1,518 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

The Leptin Receptor

1997 • 1,300 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway

1997 • 993 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Crystal Structure of the Tyrosine Phosphatase SHP-2

1998 • 940 citations

The IL-6 Signal Transducer, gp130: an Pncostatin M Receptor and Affinity Converter for the LIF Receptor

1992 • 897 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

1996 • 661 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells.

1996 • 589 citations

Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.

1991 • 587 citations

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

1996 • 572 citations

The origin and efficient derivation of embryonic stem cells in the mouse

1997 • 533 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2

1997 • 474 citations

Evidence for Involvement of Activin A and Bone Morphogenetic Protein 4 in Mammalian Mesoderm and Hematopoietic Development

1995 • 464 citations

Buffalo rat liver cells produce a diffusible activity which inhibits the differentiation of murine embryonal carcinoma and embryonic stem cells

1987 • 403 citations

Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

1997 • 402 citations

Cardiotrophin 1 (CT-1) Inhibition of Cardiac Myocyte Apoptosis via a Mitogen-activated Protein Kinase-dependent Pathway

1997 • 399 citations

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.

1994 • 389 citations

Serum response factor is essential for mesoderm formation during mouse embryogenesis

1998 • 364 citations

STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line.

1996 • 345 citations

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early xenopus development

1995 • 330 citations

Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

1994 • 319 citations

Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

1994 • 302 citations

Gab1 Acts as an Adapter Molecule Linking the Cytokine Receptor gp130 to ERK Mitogen-Activated Protein Kinase

1998 • 287 citations

Withdrawal of differentiation inhibitory activity/leukemia inhibitory factor up-regulates D-type cyclins and cyclin-dependent kinase inhibitors in mouse embryonic stem cells.

1996 • 256 citations

Multiple Requirements for SHPTP2 in Epidermal Growth Factor-Mediated Cell Cycle Progression

1996 • 247 citations

Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Promoted Tyrosyl Phosphorylation of Insulin Receptor Substrate-1

1995 • 246 citations

Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblasts.

1994 • 242 citations

Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways

1994 • 223 citations

Leukemia Inhibitory Factor–dependent Transcriptional Activation in Embryonic Stem Cells

1997 • 217 citations

Daughter of Sevenless Is a Substrate of the Phosphotyrosine Phosphatase Corkscrew and Functions during Sevenless Signaling

1996 • 210 citations

Involvement of STAT3 in the Granulocyte Colony-stimulating Factor-induced Differentiation of Myeloid Cells

1997 • 183 citations

Extrauterine Growth of Mouse Egg-cylinders results in Malignant Teratoma

1970 • 176 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.

1994 • 172 citations

Internal ribosome entry sites and dicistronic RNAs in mammalian transgenesis

1995 • 168 citations

A Deletion Mutation in the SH2-N Domain of Shp-2 Severely Suppresses Hematopoietic Cell Development

1997 • 167 citations

Differential activation of p44mapk (ERK1) by α-thrombin and thrombin-receptor peptide agonist

1993 • 163 citations

Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells.

1994 • 162 citations

Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines

1995 • 160 citations

Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development

1995 • 155 citations

gp130-mediated Signal Transduction in Embryonic Stem Cells Involves Activation of Jak and Ras/Mitogen-activated Protein Kinase Pathways

1996 • 147 citations

Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6

1997 • 146 citations

Genetic analysis of protein tyrosine phosphatases

1998 • 145 citations

Paracrine Induction of Stem Cell Renewal by LIF-Deficient Cells: A New ES Cell Regulatory Pathway

1998 • 126 citations

The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression

1997 • 122 citations

Protein Tyrosine Phosphatase 2 (SHP-2) Moderates Signaling by gp130 but Is Not Required for the Induction of Acute-Phase Plasma Protein Genes in Hepatic Cells

1998 • 121 citations

Oncostatin M binds the high-affinity leukemia inhibitory factor receptor.

1992 • 117 citations

Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells

1994 • 109 citations

Derivation of Germline Competent Embryonic Stem Cells with a Combination of Interleukin-6 and Soluble Interleukin-6 Receptor

1994 • 87 citations

Leptin receptor (OB‐R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130

1997 • 82 citations

Maintenance of an extrachromosomal plasmid vector in mouse embryonic stem cells.

1995 • 80 citations

Shp-2 has a positive regulatory role in ES cell differentiation and proliferation

1998 • 75 citations

Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase.

1997 • 69 citations

Coordinate Regulation of STAT Signaling and c-fosExpression by the Tyrosine Phosphatase SHP-2

1998 • 62 citations

Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells.

1994 • 57 citations

Teratocarcinogenesis as related to the age of embryos grafted under the kidney capsule

1971 • 42 citations

STAT3 activation is a critical step in gp130 mediated-terminal differentiation and growth arrest of a myeloid cell line

2000 • 31 citations

Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development

1996 • 4 citations

Differential activation of p44mapk (ERK1) by alpha-thrombin and thrombin-receptor peptide agonist.

1993 • 2 citations