Latent transforming growth factor-β is present in the extracellular matrix of embryonic hearts in situ

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

Current topics in developmental biology

1998 • 1,090 citations

Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.

1988 • 962 citations

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.

1989 • 914 citations

Role of transforming growth factor-beta in the development of the mouse embryo.

1987 • 760 citations

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.

1990 • 740 citations

Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development.

1991 • 677 citations

Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro.

1987 • 561 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

The cell biology of transforming growth factor β

1990 • 537 citations

Embryonic gene expression patterns of TGF β1, β2 and β3 suggest different developmental functions in vivo

1991 • 499 citations

Immunodetection and quantitation of the two forms of transforming growth factor‐beta (TGF‐β1 and TGF‐β2) secreted by cells in culture

1989 • 453 citations

Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein

1994 • 450 citations

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.

1990 • 449 citations

Transforming growth factor-beta activation in irradiated murine mammary gland.

1994 • 414 citations

Regulation of Transforming Growth Factor-β Activation by Discrete Sequences of Thrombospondin 1

1995 • 413 citations

A new type of transforming growth factor-beta, TGF-beta 3.

1988 • 396 citations

Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions

1985 • 366 citations

Normal embryo fibroblasts release transforming growth factors in a latent form

1984 • 336 citations

Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide.

1988 • 273 citations

Transforming growth factor-β: Multiple effects on cell differentiation and extracellular matrices

1988 • 271 citations

Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxynucleotide to transforming growth factor beta 3.

1991 • 263 citations

Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells.

1993 • 241 citations

Complementary Deoxyribonucleic Acid Cloning of a Messenger Ribonucleic Acid Encoding Transforming Growth Factor β 4 from Chicken Embryo Chondrocytes

1988 • 227 citations

Identification of a novel transforming growth factor-beta (TGF-beta 5) mRNA in Xenopus laevis.

1990 • 177 citations

RNA and protein localisations of TGFβ2 in the early mouse embryo suggest an involvement in cardiac development

1993 • 166 citations

Extracellular matrix from embryonic myocardium elicits an early morphogenetic event in cardiac endothelial differentiation

1987 • 129 citations

Interactions between retinoids and TGF βs in mouse morphogenesis

1992 • 124 citations

Plasminogen‐dependent activation of latent transforming growth factor beta (TGFβ) by growing cultures of osteoblast‐like cells

1993 • 124 citations

Distribution of basement membrane antigens in cryopreserved early embryonic hearts

1987 • 121 citations

The mechanism for the activation of latent TGF-beta during co-culture of endothelial cells and smooth muscle cells: cell-type specific targeting of latent TGF-beta to smooth muscle cells.

1993 • 114 citations

Regulation of mammary morphogenesis: Evidence for extracellular matrix-mediated inhibition of ductal budding by transforming growth factor-β1

1992 • 114 citations

Transforming Growth Factor‐β: A Family of Growth Regulatory Peptides

1990 • 88 citations

The murine type II TGF-β receptor has a coincident embryonic expression and binding preference for TGF-β1

1994 • 87 citations

Expression of transforming growth factor-βs 1–4 in chicken embryo chondrocytes and myocytes

1991 • 86 citations

Conditioning of native substrates by chondroitin sulfate proteoglycans during cardiac mesenchymal cell migration.

1986 • 79 citations

Sense and antisense TGFβ3 mRNA levels correlate with cardiac valve induction

1992 • 78 citations

Expression of transforming growth factor-β2 and β3 mRNAs and proteins in the developing chicken embryo

1994 • 77 citations

Myocardial Regulation of Transforming Growth Factor-β Expression by Outflow Tract Endothelium in the Early Embryonic Chick Heart

1994 • 72 citations

Complementary Deoxyribonucleic Acid Cloning of an mRNA Encoding Transforming Growth Factor- β2 from Chicken Embryo Chondrocytes

1990 • 69 citations

Cloning and developmental expression of the chick type II and type III TGFβ receptors

1994 • 59 citations

Cranial Neural Crest Cells Synthesize and Secrete a Latent Form of Transforming Growth Factor β That Can Be Activated by Neural Crest Cell Proteolysis

1993 • 58 citations

Molecular Cloning and Primary Structure of the Chicken Transforming Growth Factor-β2 Gene

1991 • 50 citations

Latent Forms of TGF‐β: Structure and Biology

1990 • 49 citations

Urokinase activity in the developing avian heart: A spatial and temporal analysis

1992 • 42 citations

Molecular Characterization of Transforming Growth Factor Type β3^a

1990 • 37 citations

Specific configurations of fibronectin‐containing particles correlate with pathways taken by neural crest cells at two axial levels

1988 • 29 citations

Transforming growth factor-?1 localized within the heart of the chick embryo

1991 • 19 citations

Porcine granulosa cells do not express transforming growth factor-beta 2 (TGF-beta 2) messenger ribonucleic acid: molecular basis for their inability to produce TGF-beta activity comparable to that of rat granulosa cells.

1992 • 17 citations

Analysis of Proteolytic Cleavage of Recombinant TGF‐β1: Production of Hybrid Molecules with Increased Processing Efficiency

1990 • 9 citations